Helicobacter Pylori Infection in Children with Type 1 Diabetes Mellitus

Sohair B. Fayed; Soha M. Abd El Dayem; Ensaf Khalil; Mona Abd El Kader; Eatemad Abd El Halim

doi:10.3889/oamjms.2014.020

Authors

Sohair B. Fayed Pediatrics Department, Faculty of Medicine for Girls, Al- Azhar University, Cairo
Soha M. Abd El Dayem Pediatrics Department, National Research Centre, Cairo
Ensaf Khalil Pediatrics Department, Faculty of Medicine for Girls, Al- Azhar University, Cairo
Mona Abd El Kader Clinical Pathology Department, National Research Centre, Cairo
Eatemad Abd El Halim Pediatrics Department, Faculty of Medicine for Girls, Al- Azhar University, Cairo

DOI:

https://doi.org/10.3889/oamjms.2014.020

Keywords:

Helicobacter pylori, children, type 1 diabetes mellitus.

Abstract

Objective: To evaluate H. pylori infection and virulent strain in diabetic children.

Patients: In this study 53 type 1 diabetics and 53 of normal volunteers were included.

Methods: All studied children were subjected to assessment of glycosylated hemoglobin (HbA1), Anti H. pylori antibodies (IgA, IgG, IgM), Anti-cytotoxin associated gene A antibodies (Anti Cag A IgG).

Results: Anti H. pylori antibodies IgA, IgG, total antibodies and anti Cag A IgG were significantly higher in diabetics. Diabetic patients with positive anti Cag A IgG had a lower age of onset of diabetes, higher age of patients, body mass index (BMI) and HbA1.

Conclusion: High prevalence of infection with the virulent strain of H. pylori among diabetic children with older age, large BMI, high HbA1 and younger age of onset of disease. The screening for the virulent strain in diabetic patients with poor metabolic control is mandatory. Control of diabetes is essential to present the infection with H. pylori.

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