Immune Response and Nutritional Status of Infants’ Birth after Supplementation with Dadih and Zinc during Pregnancy: A Prospective Intervention Study
DOI:
https://doi.org/10.3889/oamjms.2023.11640Keywords:
Dadih, Infants, Nutritional status, Prosfective study, Secretory immunoglobulin AAbstract
BACKGROUND: Dadih is an Indonesian traditional fermented buffalo milk produced and consumed by the secretory immunoglobulin A (sIgA) level and nutritional status of infants aged 4–10 months.
AIM: This study aims to assess the effect of dadih and zinc supplementation given to pregnant mothers for 6 months on fecal.
MATERIALS AND METHODS: A prospective randomized controlled trial was conducted in two districts on 138 pregnant mothers for 6 months, randomly assigned into three groups, namely, control, dadih, combination of dadih and zinc groups. Then, the combination of groups was supplemented to expecting mothers, respectively, 6 times a week during 6 months. Anthropometric measurement and fecal sIgA of infants were assessed.
RESULTS: The prevalence of nutritional status of infants who mothers were supplemented during pregnancy with dadih, dadih and zinc, and, normal diet, respectively, are 10% stunting, 5.0% underweight, and 5.0% wasting infants; and 22.5% stunted, 20.0% underweight, and 5.0% wasting infants were found in expecting mothers supplemented with it and without any supplementation (control group). The percentage of stunting in 8 months and older infants tended to reduce: 28.57%, 31.25%, and 11.76%. Their mothers were supplemented with all groups.
CONCLUSION: Dadih and zinc are potential for improving nutritional status of the newborn. In addition, the two types of supplementation are recommended to pregnant mothers, to reduce the prevalence of stunting. Potential probiotic contained in Dadih which consumed in adequate amounts can help the absorption of nutrients and increase immunity of mothers and infants amounts confer a health benefit. Acceleration and growth of infants to achieve optimal growth and development should be carried out before they are under two years old.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Allen LH, Gillespie SR. What Works? A Review of the Efficacy and Effectiveness of Nutrition Interventions. Philippines: Asian Development Bank; 2001. Available from: https://hdl.handle. net/11540/275 [Last accessed on 2023 Apr 02].
Indonesian Ministry of Health. Stunting Bulletin. Jakarta: Republic of Indonesia Ministry of Health: 2018.
Republic of Indonesia Ministry of Health. Pocket Book of Results of the 2021 Regency/City Indonesian Nutrition Status Study (SSGI). Jakarta: Republic of Indonesia Ministry of Health. 2021.
Helmizar H, Jalal P, Lipoeto NI, Achadi EL. Local food supplementation and psychosocial stimulation improve linear growth and cognitive development among Indonesian infants aged 6 to 9 months. Asia Pac J Clin Nutr. 2015;26(1):97-103. https://doi.org/10.6133/apjcn.102015.10 PMid:28049268
Ibs KH, Rink L. Zinc-altered immune function. J Nutr. 2003;133(5 suppl 1):1452S-6S. https://doi.org/10.1093/jn/133.5.1452S PMid:12730441 DOI: https://doi.org/10.1093/jn/133.5.1452S
Ministry of Health of the Republic of Indonesia. Decree of the Minister of Health of the Republic of Indonesia Number: 1995/Menkes/SK/XII/2010 Concerning Anthropometric Standards for Assessment of Children’s Nutritional Status. Directorate of Nutrition Development. Jakarta: Ministry of Health of the Republic of Indonesia; 2011.
Rokc C, Subandoro A, Gallagher P. Aiming High; Indonesia’s Ambition to Reduce Stunting. United States: International Bank for Reconstruction and Development/The World Bank; 2018.
Sharif DR, Lestari ED, Mexitalia M, Nasar S. Textbook of Pediatric Nutrition and Metabolic Diseases. Vol. 1. Jakarta: Ikatan Dokter Anak Indonesia; 2011.
Engle PL, Menon P, Haddad L. Care and nutrition: Concepts and measurement. World Development. 1999;27(8):1309-37. https://doi.org/10.1016/S0305-750X(99)00059-5 DOI: https://doi.org/10.1016/S0305-750X(99)00059-5
Gebremedhin S, Enquselassie F, Umeta M. Prevalence of prenatal zinc deficiency and its association with socio- demographic, dietary and health care related factors in rural Sidama, Southern Ethiopia: A cross-sectional study. BMC Public Health. 2011;11:898. https://doi.org/10.1186/1471-2458-11-898 PMid:22126192 DOI: https://doi.org/10.1186/1471-2458-11-898
Blackburn ST. Maternal, Fetal & Neonatal Physiology: A Clinical Perspective. 4th ed. Washington, D.C: Saunders; 2013.
Busra M, Elhassan EM, Ali NI, Osman E, Bakheit KH, Adam II. Anaemia, zinc and copper deficiencies among pregnant women in central Sudan. Biol Trace Elem Res. 2010;137(3):255-61. https://doi.org/10.1007/s12011-009-8586-4 PMid:20039147 DOI: https://doi.org/10.1007/s12011-009-8586-4
Donangelo CM, Zapata CL, Woodhouse LR, Shames DM, Mukherjea R, King JC. Zinc absorption and kinetics during pregnancy and lactation in Brazilian women. Am J Clin Nutr. 2005;82(1):118-24. https://doi.org/10.1093/ajcn.82.1.118 PMid:16002809 DOI: https://doi.org/10.1093/ajcn.82.1.118
Donangelo CM, King JC. Maternal zinc intakes and homeostatic adjustments during pregnancy and lactation. Nutrients.
;4(7):782-98. https://doi.org/10.3390/nu4070782 PMid:22852063 DOI: https://doi.org/10.3390/nu4070782
FAO, WHO. Human Vitamin and Mineral Requirements. Report of a Joint FAO/WHO Expert Consultation Bangkok, Thailand. Food and Nutrition Division. Rome: FAO; 2001.
Putra AA, Marlida Y, Khasrad K, Azhike SY, Wulandari R. Development and business of Dadih development: A review of traditional Minangkabau fermented milk. Indones Anim Husbandry J. 2011;13(3):159-70. https://doi.org/10.25077/jpi.13.3.159-170.2011 DOI: https://doi.org/10.25077/jpi.13.3.159-170.2011
Geissler CA, Powers HJ. Human Nutrition. 11th ed. Netherlands: Elsevier, Churchill Livingstone; 2005.
Gibbney MJ, Langham SA, Cassidie A, Vorster HH. Introduction to Human Nutrition. 2nd ed. USA: Wiley Black Well; 2009.
Surono I, Martono PD, Kameo S, Suradji EW, Koyama H. Effect of probiotic L. plantarum IS-10506 and zinc supplementation on humoral immune response and Zinc status of Indonesia pre-school children. J Trace Elem Med Biol. 2014;28(4):465-9. https://doi.org/10.1016/j.jtemb.2014.07.009 PMid:25183688 DOI: https://doi.org/10.1016/j.jtemb.2014.07.009
Giles E, Doyle LW. Zinc in extremely low birthweight or very preterm infants. Neoreviews. 2007;8(4):e165-72. https://doi.org/10.1542/neo.8-4-e165 DOI: https://doi.org/10.1542/neo.8-4-e165
Gropper SA, Smith JL, Groff JL. Advance Nutrition and Human Metabolism. 5th ed. USA: Wadsworth Cengage Learning; 2009.
Gunaratna NS, Masanja H, Mrema S, Lavira F, Splegeiman D, Hertzmark E, et al. Multivitamin and iron supplementation to prevent periconceptional anemia in rural Tanzanian women: A randomized, controlled trial. PLoS One. 2015;10(4):e0121552. https://doi.org/10.1371/journal.pone.0121552 PMid:25905863 DOI: https://doi.org/10.1371/journal.pone.0121552
Helmizar H. The Effect of Dadih and Zinc Supplementation during Pregnancy on Humoral Immune Response and Birth Weight of Infants in West Sumatra Province. Indonesia. Research Grant Report Institute Danone Foundation Indonesia; 2017.
Ma AG, Schouten EG, Wang Y, Xu RX, Zheng MC, Li Y, et al. Micronutrient status in anemic and non-anemic Chinese women in the third trimester of pregnant. Asia Pac J Clin Nutr. 2009;18(1):41-7. PMid:19329394
Hoffbrand AV, Moss PA. Kapita Selekta Hematology. 6th ed. Jakarta: EGC Medical Book Publisher; 2013.
International Zinc Nutrition Consultative Group (IZiNCG), Rivera JA, Bhutta Z, Gibson RS, Hotz C, Brown KH, et al. International Zinc Nutrition Consultative Group (IZiNCG) technical documents #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull. 2004;25(1 Suppl 2):S99-203. https://doi.org/10.4067/S0717-75182010000200014 PMid:18046856 DOI: https://doi.org/10.1177/156482650402500220
Geissler C, Powers H. Human Nutrition. 11th ed. Netherlands: Elsevier, Churchill Livingstone; 2005.
Shankar AH, Prasad AS. Zinc and immune function: The biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68(2 suppl):447S-63S. https://doi.org/10.1093/ajcn/68.2.447S PMid:9701160 DOI: https://doi.org/10.1093/ajcn/68.2.447S
Mujica-Coopman MF, Borja A, Pizarro F, Olivers M. Effect of daily supplementation with iron and zinc on iron status of childbearing age women. Biol Trace Elem Res. 2015;165(1):10-7. https://doi.org/10.1007/s12011-014-0226-y PMid:25582309 DOI: https://doi.org/10.1007/s12011-014-0226-y
Mei Z, Serdula MK, Liu JM, Flores-Ayala RC, Wang L, Ye W, et al. Iron-containing micronutrient supplementation of Chinese women with no or mild anemia during pregnancy improved iron status but did not affect perinatal anemia. J Nutr. 2014;144(6):943-8. https://doi.org/10.3945/jn.113.189894 PMid:24744317 DOI: https://doi.org/10.3945/jn.113.189894
Proverawati A, Asfuah S. Nutrition Textbook for Midwifery. Yogyakarta: Nuha Medika; 2009. p. 76,78,79.
Basic Health Research (Riskesdas). Health Research and Development Agency Ministry Health RI; 2013. Available from: https://depkes.go.id/downloads/riskesdas2013/results%20 riskesdas%202013.pdf [Last accessed on 2023 Mar 25].
Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013;18(2):144-57. PMid:23914218
Samimi M, Asemi Z, Taghizadeh M, Azarbad Z, Rahimi- Foroushani A, Sarahroodi S. Concentrations of serum zinc, hemoglobin and ferritin among pregnant women and their effects on birth outcomes in Kashan, Iran. Oman Med J. 2012;27(1):40-5. https://doi.org/10.5001/omj.2012.08 PMid:22359724 DOI: https://doi.org/10.5001/omj.2012.08
Shils ME, Shike M, Ross AC, Caballero E, Cousins RJ. Modern Nutrition in Health and Disease. 10th ed. United States: Lippincott Williams and Wilkins; 2006.
Sutiana S. Effects of Giving Iron Tablets, Zinc Capsules, and Nutrition Education on Hemoglobin Levels of Pregnant Women in Maros Regency, South Sulawesi Province. Thesis. Makassar: Hasanuddin University. 2015.
Tran TC, Fisher J, Haniah S, Tran T, Simpaon JA, Tran H, et al. Antenatal iron supplementation regimens for pregnant women in rural Vietnam and subsequent haemoglobin concentration and anaemia among their infants. PLoS One. 2015;10(4):e0125740. https://doi.org/10.1371/journal.pone.0125740 PMid:25928545 DOI: https://doi.org/10.1371/journal.pone.0125740
Walker CF, Kordas K, Stoltzfus RJ, Black RE. Interactive effects of iron and zinc on biochemical and functional outcomes in supplementation trials. Am J Clin Nutr. 2005;82(1):5-12. https://doi.org/10.1093/ajcn.82.1.5 PMid:16002793 DOI: https://doi.org/10.1093/ajcn.82.1.5
WHO. Maternal Mortality. Available from: https://www.who.int/ gho/maternal_health/mortality/maternal_mortality_text.2014 [Last accessed on 2023 Mar 12].
Zhao N, Wang X, Zhang Y, Gu Q, Huang F, Zheng W, et al. Gestational zinc deficiency impairs humoral and cellular immune responses to hepatitis B vaccination in offspring mice. PLoS One. 2013;8(9):e73461. https://doi.org/10.1371/journal.pone.0073461 PMid:24069198 DOI: https://doi.org/10.1371/journal.pone.0073461
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2023 Helmizar Helmizar, Sri Rahma Sari, Utami Ariyasra, Andani Eka Putra (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0
Funding data
-
Instituto Danone
Grant numbers NO:012/ROG-I/IDIF/X/2016)