A Comparative Evaluation of the Sealing Ability, Adaptability and Antibacterial Effect of Nano MTA Plus Versus Conventional MTA Fillapex: An In-Vitro Study


  • Marina S. Fahmy Departmemt of Endodontics, Faculty of Dentistry, Minia University, Minya, Egypt https://orcid.org/0009-0007-8948-8522
  • Maged M. Negm Department of Endodontics image/svg+xml
  • Noha A. Hassuna Associate Professor of Microbiology and Immunology, Faculty of Medicine, Minia University, Minya, Egypt https://orcid.org/0000-0001-6702-2341
  • Mohammed Turky Department of Endodontics, Faculty of Dentistry, Cairo University, Giza, Egypt




apical sealing ability, antibacterial effect, bacterial leakage, nanotechnology, scanning electron microscopy


AIM: To compare nano-mineral trioxide aggregate (MTA) Plus with MTA Fillapex sealers regarding their sealing ability, adaptability, and antibacterial effect.

METHODS: Forty freshly extracted sound single-rooted permanent maxillary central incisors were used. Following access cavity preparation and root canal preparation. All the samples (n = 40) were randomly and equally categorized into two groups (n = 20 each) according to the sealer employed: group I, in which MTA Fillapex was utilized, and group II, in which nano-MTA Plus was applied. Obturation of root canals was accomplished using the lateral compaction technique. Decoronation of all teeth was performed for standardization of the root length at 12 mm. Roots were submerged in a 2% methylene blue dye solution for 72 h. The roots were divided lengthwise. Linear apical dye penetration and gaps between gutta-percha and dentin were measured under a stereomicroscope at 30× magnification to determine the sealing ability and adaptability, respectively. While the antibacterial activity against Enterococcus faecalis was tested using the Agar Diffusion Test (ADT). Data were statistically estimated utilizing the Mann-Whitney test, Spearman’s correlation coefficient examination, and the independent T-test.

RESULTS: Although Nano-MTA Plus showed higher sealing ability and lower antibacterial action than MTA Fillapex, we didn’t record any statistically substantial variation (2.05 ± 1.43 mm and 11.00 ± 9.42 mm, respectively), (2.10 ± 1.17 mm and 14.25 ± 6.70 mm, respectively). While statistical significance was reported in adaptability, Nano-MTA Plus showed a statistically significant lower adaptability compared with MTA Fillapex (57.89 ± 23.45 μm and 26.82 ± 16.55 μm, respectively).

CONCLUSION: Nano-MTA Plus and MTA Fillapex have comparable sealing abilities, and antibacterial effects. While MTA Fillapex was superior to Nano-MTA Plus regarding adaptability.


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Author Biography

Maged M. Negm, Department of Endodontics

Professor of Endodontics, Faculty of Dentistry, Cairo University


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How to Cite

Fahmy MS, Negm MM, Hassuna NA, Turky M. A Comparative Evaluation of the Sealing Ability, Adaptability and Antibacterial Effect of Nano MTA Plus Versus Conventional MTA Fillapex: An In-Vitro Study. Open Access Maced J Med Sci [Internet]. 2024 Apr. 15 [cited 2024 May 26];12:1-6. Available from: https://oamjms.eu/index.php/mjms/article/view/11847



Dental Pathology and Endodontics