Clinical Features of Patients with Probable 2019 Novel Coronavirus Infected Pneumonia in Rasht, Iran: A Retrospective Case Series

Authors

  • Samad Karkhah Student Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
  • Mohammad Javad Ghazanfari Student Research Committee, School of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran
  • Amir Shamshirian Department of Medical Laboratory Sciences, Student Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran; Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Latif Panahi Student Research Committee, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
  • Meysam Molai Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Amir Emami Zeydi Department of Medical-Surgical Nursing, Nasibeh School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran

DOI:

https://doi.org/10.3889/oamjms.2020.4755

Keywords:

COVID19, Iran, COVID-19 diagnostic testing, Pneumonia, Viral

Abstract

BACKGROUND: Coronavirus disease-19 (COVID-19) is the first pandemic infectious disease caused by a novel coronavirus. Viral pneumonia is a severe complication of COVID-19.

AIM: Due to the high prevalence of this disease globally, especially in Iran, the aim of this study was to determine the clinical features of seven patients with probable COVID-19 infected pneumonia in Rasht, North Iran.

MATERIALS AND METHODS: In this retrospective case series study, we described the clinical, laboratory, and radiological features of seven patients with probable COVID-19 infected pneumonia at Razi Hospital, Rasht, north of Iran, from February 27 to March 16, 2020.

RESULTS: In this study, the most common clinical symptoms during hospitalization in patients with COVID-19 were poor appetite (seven cases), dehydration (seven cases), cough (six cases), dyspnea (six cases), fatigue (six cases), fever above 38°C (five cases), myalgia (five cases), Chills (five cases), feeling fever (five cases), sore throat (five cases), and nausea (five cases), respectively. The average body temperature in these patients was 39.32°C. In laboratory findings, erythrocyte sedimentation rate was elevated in three patients. Contrary to most of the evidence, C-reactive protein was not elevated in five patients. All patients received antibiotic and antiviral medications and received symptomatic treatment. Finally, four patients responded to the treatments and were discharged from the hospital; two patients were still hospitalized and only one patient died.

CONCLUSION: Patients with COVID-19 associated pneumonia can be treated by evaluating and implementing appropriate therapeutic management. However, at the moment the disease progression for patients with COVID-19 cannot be accurately predicted.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020;395:507-13. https://doi.org/10.1016/ S0140-6736(20)30211-7 PMid:32007143

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. https://doi. org/10.1016/S0140-6736(20)30183-5 PMid:31986264

Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, et al. Clinical characteristics of coronavirus disease 2019 (COVID- 19) in China: A systematic review and meta-analysis. J Infect 2020;80(6):656-65. https://doi.org/10.1016/j.jinf.2020.03.041 PMid: 32283155

Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA. 2020;323(14):1406-7. https://doi.org/10.1001/jama.2020.2565 PMid:32083643.

Singhal T. A review of coronavirus disease-2019 (COVID-19). Indian J Pediatr 2020;87(4):281-6. PMid: 32166607

Wu YC, Chen CS, Chan YJ. The outbreak of COVID-19: An overview. J Chin Med Assoc 2020;83(3):217-20. https://doi. org/10.1097/JCMA.0000000000000270 PMid: 3213486

Coronavirus disease 2019 (COVID-19) Situation Report 57. Available from: https://www.who.int/docs/default-source/ coronaviruse/situation-reports/20200317-sitrep-57-covid-19. pdf?sfvrsn=a26922f2_4. [Last accessed on 2020 May 30].

Abdi M. Coronavirus disease 2019 (COVID-19) outbreak in Iran: Actions and problems. Infect Control Hosp Epidemiol. 2020;41(6):754-5. https://doi.org/10.1017/ice.2020.86 PMid:32192541

Huang X, Wei F, Hu L, Wen L, Chen K. Epidemiology and clinical characteristics of COVID-19. Arch Iran Med 2020;23(4):268-71. https://doi.org/10.34172/aim.2020.09 PMid: 32271601

Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X, et al. CT imaging features of 2019 novel coronavirus (2019- nCoV). Radiology. 2020;295(1):202-7. http://dx.doi.org/10.1148/ radiol.2020200230 PMid:32017661

Kolifarhood G, Aghaali M, Saadati HM, Taherpour N, Rahimi S, Izadi N, et al. Epidemiological and clinical aspects of COVID-19; a narrative review. Arch Acad Emerg Med 2020;8(1):e41. PMid: 32259130

Carlos WG, Dela Cruz CS, Cao B, Pasnick S, Jamil S. Novel Wuhan (2019-nCoV) Coronavirus. Am J Respir Crit Care Med. 2020;201(4):P7-8. http://dx.doi.org/10.1164/rccm.2014P7 PMid:32004066

Mahdavi A, Khalili N, Davarpanah AH, Faghihi T, Mahdavi A, Haseli S, et al. Radiologic management of COVID-19: Preliminary experience of the Iranian society of radiology COVID-19 consultant group (ISRCC). Iran J Radiol. 2020;17(2):e102324. https://doi.org/10.5812/iranjradiol.102324

Cherry J, Krogstad P. SARS: The 1st pandemic of the 21st Century. Pediatr Res. 2004;56(1):1-5. https://doi.org/10.1203/01. PDR.0000129184.87042.FC PMid:15152053

Azhar EI, El-Kafrawy SA, Farraj SA, Hassan AM, Al-Saeed MS, Hashem AM, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014;370(26):2499-505. https://doi.org/10.1056/NEJMoa1401505 PMid:24896817

Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018;23(2):130-7. https:// doi.org/10.1111/resp.13196 PMid:29052924

Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series. BMJ. 2020;368:m606. https://doi. org/10.1136/bmj.m606 PMid:32075786

Badawi A, Ryoo SG. Prevalence of comor twice dailyities in the Middle East respiratory syndrome coronavirus (MERS-CoV): A systematic review and meta-analysis. Int J Infect Dis. 2016;49:129-33. https://doi.org/10.1016/j.ijid.2016.06.015 PMid:27352628.

Channappanavar R, Fett C, Mack M, Ten Eyck PP, Meyerholz DK, Perlman S. Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection. J Immunol. 2017;198(10):4046-53. https://doi.org/10.4049/jimmunol.1601896 PMid:28373583

Wang X, Yuan J, Zheng Y, Chen J, Bao Y, Wang Y, et al. Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen. Zhonghua Er Ke Za Zhi. 2020;58:E008. https://doi.org/10.3760/ cma.j.issn.0578-1310.2020.0008 PMid:32062875

Wang L. C-reactive protein levels in the early stage of COVID-19. Med Mal Infect 2020;50(4):332-4. https://doi.org/10.1016/j. medmal.2020.03.007 PMid: 32243911

Chen L, Liu H, Liu W, Liu J, Liu K, Shang J,et al. Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 2020;43:E005. https://doi.org/10.3760/cma.j.issn.1001-0939.2020.0005 PMid:32026671

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet. 2020;395(10226):809-15. https://doi.org/10.1016/S0140-6736(20)30360-3 PMid:32151335

Shirani K, Hajzargarbashi ST. Comparison of serum CRP, PCT and STREM-1 in ventilator-associated pneumonia (VAP) positive and VAP negative in ICU patients. J Biochem Technol. 2009;2:133-8.

Zhang G, Zhang J, Wang B, Zhu X, Wang Q, Qiu S. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A retrospective analysis. Respir Res 2020;21(1):74. https://doi. org/10.1186/s12931-020-01338-8 PMid: 32216803

Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. J Infect 2020;80(6):e14-8. https://doi.org/10.1016/j. jinf.2020.03.005 PMid: 32171866

Zhang Z, Li X, Zhang W, Shi ZL, Zheng Z, Wang T. Clinical features and treatment of 2019-nCoV pneumonia patients in Wuhan: Report of a couple cases. Virol Sin. 2020 Feb 7;1-7. https://doi.org/10.1007/s12250-020-00203-8 PMid:32034637

Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020;11(1):1-14. https://doi. org/10.1038/s41467-019-13940-6 PMid:31924756

Downloads

Published

2020-05-10

How to Cite

1.
Karkhah S, Ghazanfari MJ, Shamshirian A, Panahi L, Molai M, Zeydi AE. Clinical Features of Patients with Probable 2019 Novel Coronavirus Infected Pneumonia in Rasht, Iran: A Retrospective Case Series. Open Access Maced J Med Sci [Internet]. 2020 May 10 [cited 2024 Apr. 20];8(T1):16-22. Available from: https://oamjms.eu/index.php/mjms/article/view/4755