Comparative Characteristics of Metabolic Parameters in Patients with Psoriasis and Lichen Planus

Alla Bilovol; Svitlana Tkachenko; Oleksandra Havryliuk; Alla Berehehova; Nataliia Pustova; Nataliia Kolhanova; Yulia Drozd

doi:10.3889/oamjms.2022.8708

Authors

Alla Bilovol Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine
Svitlana Tkachenko Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine
Oleksandra Havryliuk Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine; SE “Institute of Dermatology and Venereology of National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine https://orcid.org/0000-0003-0596-723X
Alla Berehehova Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine
Nataliia Pustova Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine
Nataliia Kolhanova Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine
Yulia Drozd Department of Dermatology, Kharkiv National Medical University, Venereology and Medical Cosmetology, Kharkiv, Ukraine

DOI:

https://doi.org/10.3889/oamjms.2022.8708

Keywords:

Psoriasis, Lichen planus, Lichenoid dermatosis, Lipids, Metabolism

Abstract

AIM: The aim of the study was to assess metabolic parameters in patients with lichenoid dermatoses.

METHODS: The study of indicators of metabolic processes was performed on two groups of patients: first group consisted of 50 patients with psoriasis, of whom there were 20 women and 30 men, the average age was 41.3 years; second group included 50 patients with lichen planus, including 23 women and 27 men, the average age was 40.9 years. The control group consisted of 15 healthy individuals, comparable age and gender, whose indicators were considered normal.

CONCLUSIONS: Deviations of lipid metabolism in patients with psoriasis and lichen planus were detected, which were unidirectional with a significant increase in total cholesterol (27% and 30%, respectively) and low-density lipoprotein cholesterol (17% and 21%, respectively).

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References

Slesarenko NA, Utz SR, Bakulev AL, Davtyan VA, Yepifanova AY, Reshetnikova YM, et al. Sluchay sochetaniya shipovidnogo folliculyarnogo keratoza Krokkera-Adamsona, krasnogo ploskogo lishaya i syndroma Littla-Lassuera u yunoshi 17 let. [A case of a combination of Crocker-Adamson follicular spinulosa, lichen acuminatus and Little-Lassueur syndrome]. Vestnik Dermatol Venerol. 2014;4:68-74. DOI: https://doi.org/10.25208/0042-4609-2014-90-4-68-74

Yeung H, Takeshita J, Mehta NN, Kimmel SE, Ogdie A, Margolis DJ, et al. Psoriasis sevirity and the prevalence of major medical comorbidity: A population-based study. JAMA Dermatol. 2013;140(10):1173-9. http://doi.org/10.1001/jamadermatol.2013.5015 PMid:23925466 DOI: https://doi.org/10.1001/jamadermatol.2013.5015

Polic MV, Miskulin M, Smolic M, Kralik K, Miskulin I, Berkovic MC, et al. Psoriasis severity-a risk factor of insulin resistance independent of metabolic syndrome. Int J Environ Res Public Health. 2018;15(7):1486. http://doi.org/10.3390/ijerph15071486 PMid:30011841 DOI: https://doi.org/10.3390/ijerph15071486

Lai YC, Yew YW, Schwartz RA. Lichen planus and dyslipidemia: A systematic review and meta-analysis of observational studies. Int J Dermatol. 2016;55(5):e295-304. http://doi.org/10.1111/ijd.13234 PMid:26873870 DOI: https://doi.org/10.1111/ijd.13234

Arias-Santiago S, Buendia-Eisman A, Aneiros-Fernandez J, Girón-Prieto MS, Gutiérrez-Salmerón MT, Mellado VG, et al. Cardiovascular risk factors in patients with lichen planus. Am J Med. 2011;124(6):543-8. http://doi.org/10.1016/j.amjmed.2010.12.025 PMid:21605731 DOI: https://doi.org/10.1016/j.amjmed.2010.12.025

Alkammaz AM, Stepanenko RL. Pokaznyki lipidnogo obminu u hvoryh na psoriaz z osinnyo-litnym i pozasezonnym (zmishanym) typami perebuhu ta yihnye znachennya dlya patogenezu dermatozu [Indicators of lipid metabolism in patients with psoriasis with autumn-winter, spring-summer and off-season (mixed) types of current and their importance for the pathogenesis of dermatosis.] Ukranian J Dermatol Venereol Cosmetol. 2018;2(69):25-37. DOI: https://doi.org/10.30978/UJDVK2018-2-25

Alkammaz AM, Stepanenko RL. Lipidnyy obmin u shkiri hvorykh na psoriaz ta perspectyvy vyvchennya znachennya yoho porushen’ u patohenezi dermatozu. [Lipid metabolism in the skin of patients with psoriasis and prospects for studying the importance of its disorders in the pathogenesis of dermatosis]. Ukranian J Dermatol Venereol Cosmetol. 2019;2(73):93-8. DOI: https://doi.org/10.30978/UJDVK2019-2-93

Orlov EV, Arnautova MS, Gergel’ NI. Otsenka metabolicheskogo statusa i kletochnogo sostava krovi pri psoriaze i psoriaticheskom artrite [Assessment of metabolic status and cellular composition of blood in psoriasis and psoriatic arthritis]. Med Almanac. 2013;5(28):197-200.

Falko YV, Khyshyktuyev BC, Karavayeva TM, et al. Patogeneticheskiye aspekty obmena zhirnykh kislot s korotkoy tsep’yu i produktsii tsitokinov v porazhennykh uchastkakh kozhi pri psoriaze [Pathogenetic aspects of fat acid metabolism with short chain and production of cytokis in target affected areas of skin under psoriasis]. Clin Lab Diagn. 2012;1:33-6.

Nekipelova AV, Kalatushkina GB. HLA-antigeny u bol’nykh psoriazom i ikh vzaimosvyaz’ s pokazatelyami lipidnogo obmena [HLA antigens and their correlation with lipid metabolism indices in patients with psoriasis]. Yakut Med J. 2014;1(45):7-9.

Barrea L, Nappi F, di Somma C, Savanelli MC, Falco A, Balato A, et al. Environmental risk factors in psoriasis: The point of view of the nutritionist. Int J Environ Res Public Health. 2016;13(5):743. http://doi.org/10.3390/ijerph13070743 PMid:27455297 DOI: https://doi.org/10.3390/ijerph13070743

Jensen P, Skov L. Psoriasis and obesity. Dermatology. 2016;232(6):633-9. http://doi.org/10.1159/000455840 PMid:28226326 DOI: https://doi.org/10.1159/000455840

Carrascosa JM, Rocamora V, Fernandez-Torres RM, Jimenez-Puya R, Moreno JC, Coll-Puigserver N, et al. Obesity and psoriasis: Inflammatory nature of obesity, relationship between psoriasis and obesity, and therapeutic implications. Actas Dermosifiliogr. 2014;105(1):31-44. http://doi.org/10.1016/j.ad.2012.08.003 PMid:23177976 DOI: https://doi.org/10.1016/j.adengl.2012.08.024

Debbaneh M, Millsop JW, Bhatia BK, Koo J, Liao W. Diet and psoriasis, Part I: Impact of weight loss interventions. J Am Acad Dermatol. 2014;71(1):133-40. http://doi.org/10.1016/j.jaad.2014.02.012 PMid:24709272 DOI: https://doi.org/10.1016/j.jaad.2014.02.012

Yew YW, Lai YC, Chan R. Lichen planus epidemiology study. Ann Acad Med. 2016;45(11):516-9.