Evaluation of Kidneys’ Functional State in Acute Lymphoblastic Leukemia Patients Following Hematopoietic Stem Cell Transplantation

Aigerim Murzakhmetova; Vadim Kemaykin; Aset Kuttymuratov; Ayagul Ainabay; Assel Meiramova; Yernar Tursynbet; Bayan Ainabekova

doi:10.3889/oamjms.2022.8847

Authors

Aigerim Murzakhmetova Department of Internal Medicine, Course of Gastroenterology and Endocrinology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-1487-5487
Vadim Kemaykin National Scientific Center of Oncology and Transplantology, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-1257-2263
Aset Kuttymuratov National Scientific Center of Oncology and Transplantology, Nur-Sultan, Kazakhstan
Ayagul Ainabay Department of Internal Medicine, Course of Gastroenterology and Endocrinology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan; National Scientific Center of Oncology and Transplantology, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-1257-2263
Assel Meiramova Department of Internal Medicine, Course of Gastroenterology and Endocrinology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-4030-0783
Yernar Tursynbet Central Hospital with a Polyclinic, Ministry of Internal Affairs, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-1487-5487
Bayan Ainabekova Department of Internal Medicine, Course of Gastroenterology and Endocrinology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-5427-3931

DOI:

https://doi.org/10.3889/oamjms.2022.8847

Keywords:

Hematopoietic stem cell transplantation, Bone marrow transplantation, Acute lymphoblastic leukemia, Renal failure, Meta-analysis, Systematic review, Risk factors, Glomerular filtration rate, Complications

Abstract

BACKGROUND: Hematopoietic Stem Cell Transplantation (HSCT) has recently been a widely used method of therapy in various fields of current medicine, particularly in hematology.Some patients develop renal disorders following HSCT.

AIM: This study aims to evaluate the dynamics of changes in the functional state of the kidneys in patients with ALL after HSCT.

METHODS: In the period from 2015 to 2021, for the first time in Kazakhstan, patients with acute lymphoblastic leukemia (ALL) who underwent allogeneic and haploidentical HSCT were prospectively examined.

RESULTS: We determined that the greatest decrease in glomerular filtration rate occurred in the group of patients who underwent haploidentical bone marrow transplantation. Moreover, we believe that our results are related to known contributing risk factors, such as the type of performed transplantation and the duration of taking medications for the prevention of graft versus host disease. Our results also indicate that the lethal outcome in the group with haploidentical HSCT in the studied patients with ALL was greater than in the group with allogeneic HSCT.

CONCLUSION: In conclusion, a decrease in kidney function in patients who have survived HSCT is probably a common complication; however, further prospective studies are required to confirm these results to develop additional algorithms for the treatment and prevention of renal disorders in patients with acute leukemia after HSCT.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Available from: https://www.wbmt.org. [Last accessed on 2021 Sep 25].

Niederwieser D, Baldomero H, Szer J, Gratwohl M, Aljurf M, Atsuta Y, et al. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 2016;51(6):778-85. https://doi.org/10.1038/bmt.2016.18 PMid:26901703 DOI: https://doi.org/10.1038/bmt.2016.18

DeFilipp Z, Advani AS, Bachanova V, Cassaday RD, Deangelo DJ, Kebriaei P, et al. Hematopoietic cell transplantation in the treatment of adult acute lymphoblastic leukemia: Updated 2019 Evidence-Based Review from the American Society for Transplantation and Cellular Therapy. Biol Blood Marrow Transplant. 2019;25(11):2113-23. https://doi.org/10.1016/j.bbmt.2019.08.014 PMid:31446198 DOI: https://doi.org/10.1016/j.bbmt.2019.08.014

Simpson E, Dazzi F. Bone marrow transplantation 1957- 2019. Front Immunol. 2019;10:1246. https://doi.org/10.3389/fimmu.2019.01246 PMid:31231381 DOI: https://doi.org/10.3389/fimmu.2019.01246

Passweg JR, Baldomero H, Bader P, Bonini C, Duarte RF, Dufour C, et al. Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplant. 2017;52(6):811-7. https://doi.org/10.1038/bmt.2017.34 PMid:28287639 DOI: https://doi.org/10.1038/bmt.2017.34

Chien SH, Liu YC, Liu CJ, Ko PS, Wang HY, Hsiao LT, et al. European Group for Blood and Marrow Transplantation score correlates with outcomes of older patients undergoing allogeneic hematopoietic stem cell transplantation. J Chin Med Assoc. 2020;83(3):238-44. https://doi.org/10.1097/JCMA.0000000000000255 PMid:31904659 DOI: https://doi.org/10.1097/JCMA.0000000000000255

Pasquini MC, Wang Z, Horowitz MM, Gale RP. 2010 report from the center for international blood and marrow transplant research (CIBMTR): Current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. Clin Transplant 2010;87-105.

Sedhom R, Sedhom D, Jaimes E. Mini-review of kidney disease following hematopoietic stem cell transplant. Clin Nephrol. 2018;89(6):389-402. https://doi.org/10.5414/CN109276 PMid:29578399 DOI: https://doi.org/10.5414/CN109276

Kanduri SR, Kovvuru K, Cheungpasitporn W, Thongprayoon C, Bathini T, Garla V, et al. Kidney recovery from acute kidney injury after hematopoietic stem cell transplant: A systematic review and meta-analysis. Cureus. 2021;13(1):e12418. https://doi.org/10.7759/cureus.12418 PMid:33659105 DOI: https://doi.org/10.7759/cureus.12418

Inamoto Y, Lee SJ. Late effects of blood and marrow transplantation. Haematologica. 2017;102(4):614-25. https://doi.org/10.3324/haematol.2016.150250 PMid:28232372 DOI: https://doi.org/10.3324/haematol.2016.150250

Mii A, Shimizu A, Yamaguchi H, Tsuruoka S. Renal complications after hematopoietic stem cell transplantation: Role of graft-versus-host disease in renal thrombotic microangiopathy. J Nippon Med Sch. 2020;87(1):7-12. https://doi.org/10.1272/jnms.JNMS.2020_87-102 PMid:31776318 DOI: https://doi.org/10.1272/jnms.JNMS.2020_87-102

Wu NL, Hingorani S, Cushing-Haugen KL, Lee SJ, Chow EJ. Late kidney morbidity and mortality in hematopoietic cell transplant survivors. Transplant Cell Ther. 2021;27(5):434.e1-6. https://doi.org/10.1016/j.jtct.2021.02.013 PMid:33775588 DOI: https://doi.org/10.1016/j.jtct.2021.02.013

Yoshimura K, Kimura SI, Kawamura M, Kawamura S, Takeshita J, Yoshino N, et al. Chronic liver graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients during tapering or after stopping calcineurin inhibitors. Int J Hematol. 2021;114(6):674-81. https://doi.org/10.1007/s12185-021-03202-x PMid:34378178 DOI: https://doi.org/10.1007/s12185-021-03202-x

Giaccone L, Faraci DG, Butera S, Lia G, Di Vito C, Gabrielli G, et al. Biomarkers for acute and chronic graft versus host disease: State of the art. Expert Rev Hematol. 2021;14(1):79-96. https://doi.org/10.1080/17474086.2021.1860001 PMid:33297779 DOI: https://doi.org/10.1080/17474086.2021.1860001

Poonsombudlert K, Kewcharoen J, Prueksapraopong C, Limpruttidham N. Engraftment syndrome and acute graft-versus-host disease: A meta-analysis. Hawaii J Health Soc Welf. 2020;79(6):194-201. PMid:32524098

Piccin A, Tagnin M, Vecchiato C, Al-Khaffaf A, Beqiri L, Kaiser C, et al. Graft-versus-host disease (GvHD) of the tongue and of the oral cavity: A large retrospective study. Int J Hematol. 2018;108(6):615-21. https://doi.org/10.1007/s12185-018-2520-5 PMid:30144000 DOI: https://doi.org/10.1007/s12185-018-2520-5

Foord AM, Cushing-Haugen KL, Boeckh MJ, Carpenter PA, Flowers ME, Lee SJ, et al. Late infectious complications in hematopoietic cell transplantation survivors: a population-based study. Blood Adv. 2020;4(7):1232-41. https://doi.org/10.1182/bloodadvances.2020001470 PMid:32227211 DOI: https://doi.org/10.1182/bloodadvances.2020001470

Stohs E, Kalil AC. A sepsis screening tool for hematopoietic cell transplant recipients remains elusive. Clin Infect Dis. 2021;72(7):1230-1. https://doi.org/10.1093/cid/ciaa221 PMid:32133484 DOI: https://doi.org/10.1093/cid/ciaa221

Xia Y, Qin H, Yang J. Hepatic veno-occlusive disease development in the hematopoietic stem cell transplantation patients: Incidence and associated risk factors, a meta-analysis. Eur J Gastroenterol Hepatol. 2021;33(6):872-84. https://doi.org/10.1097/MEG.0000000000001802 PMid:32639417 DOI: https://doi.org/10.1097/MEG.0000000000001802

Karagun BS, Akbas T, Erbey F, Sasmaz İ, Antmen B. The prophylaxis of hepatic veno-occlusive disease/sinusoidal obstruction syndrome with defibrotide after hematopoietic stem cell transplantation in children: Single center experience. J Pediatr Hematol Oncol. 2022;44(1):e35-9. https://doi.org/10.1097/MPH.0000000000002379 PMid:34966102 DOI: https://doi.org/10.1097/MPH.0000000000002379

López-Fernández T, Vadillo IS, de la Guía AL, Barbier KH. Cardiovascular issues in hematopoietic stem cell transplantation (HSCT). Curr Treat Options Oncol. 2021;22(6):51. https://doi.org/10.1007/s11864-021-00850-3 PMid:33939030 DOI: https://doi.org/10.1007/s11864-021-00850-3

Chang E, Iukuridze A, Echevarria M, Teh JB, Chanson D, Ky B, et al. Feasibility and acceptability of using a telehealth platform to monitor cardiovascular risk factors in hematopoietic cell transplantation survivors at risk for cardiovascular disease. Biol Blood Marrow Transplant. 2020;26(6):1233-7. https://doi.org/10.1016/j.bbmt.2020.02.027 PMid:32171884 DOI: https://doi.org/10.1016/j.bbmt.2020.02.027

Astashchanka A, Ryan J, Lin E, Nokes B, Jamieson C, Kligerman S, et al. Pulmonary complications in hematopoietic stem cell transplant recipients – A clinician primer. J Clin Med. 2021;10(15):3227. https://doi.org/10.3390/jcm10153227 PMid:34362012 DOI: https://doi.org/10.3390/jcm10153227

Sakaguchi M, Nakayama K, Yamaguchi H, Mii A, Shimizu A, Inai K, et al. Risk factors for acute kidney injury and chronic kidney disease following allogeneic hematopoietic stem cell transplantation for hematopoietic malignancies. Acta Haematol. 2020;143(5):452-64. https://doi.org/10.1159/000504354 PMid:31822013 DOI: https://doi.org/10.1159/000504354

Hingorani S. Renal complications of hematopoietic-cell transplantation. N Engl J Med. 2016;374(23):2256-67. https://doi.org/10.1056/NEJMra1404711 PMid:27276563 DOI: https://doi.org/10.1056/NEJMra1404711

Ando M. An overview of kidney disease following hematopoietic cell transplantation. Intern Med 2018;57(11):1503-8. https://doi.org/10.2169/internalmedicine.9838-17 DOI: https://doi.org/10.2169/internalmedicine.9838-17

Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389(10075):1238-52. https://doi.org/10.1016/S0140-6736(16)32064-5 PMid:27887750 DOI: https://doi.org/10.1016/S0140-6736(16)32064-5

Vorob’ev PA, Dvoretskiĭ LI, Iaroslavtseva GN, Ainabekova BA, Miagkov AV. O sviazi mezhdu arterial’noĭ gipertonieĭ i narusheniem deformiruemosti éritrotsitov u bol’nykh s khronicheskoĭ pochechnoĭ nedostatochnost’iu [Relation between arterial hypertension and disorder of erythrocyte deformability in patients with chronic renal failure]. Ter Arkh. 1988;60(6):65-6. Russian. PMid:3206374

Shimoi T, Ando M, Munakata W, Kobayashi T, Kakihana K, Ohashi K, et al. The significant impact of acute kidney injury on CKD in patients who survived over 10 years after myeloablative allogeneic SCT. Bone Marrow Transplant. 2013;48(1):80-4. https://doi.org/10.1038/bmt.2012.85 PMid:22635246 DOI: https://doi.org/10.1038/bmt.2012.85

Cohen EP, Pais P, Moulder JE. Chronic kidney disease after hematopoietic stem cell transplantation. Semin Nephrol. 2010;30(6):627-34. https://doi.org/10.1016/j.semnephrol.2010.09.010 DOI: https://doi.org/10.1016/j.semnephrol.2010.09.010

National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002 Feb;39 2 Suppl 1:S1-266. PMid:11904577

Levey AS, Inker LA, Coresh J. GFR estimation: From physiology to public health. Am J Kidney Diseases 2014;63(5):820-34. https://doi.org/10.1053/j.ajkd.2013.12.006 DOI: https://doi.org/10.1053/j.ajkd.2013.12.006

Clinical Protocols of the Ministry of Health of the Republic of Kazakhstan. Acute Lymphoblastic Leukemia in Adults 2015. Republican Center for Health Development of the Ministry of Health of the Republic of Kazakhstan. Available from: https://www.rcrz.kz [Last accessed on 2021 Sep 25].

Ellis MJ, Parikh CR, Inrig JK, Kanbay M, Patel UD. Chronic kidney disease after hematopoietic cell transplantation: A systematic review [published correction appears in Am J Transplant. 2009 Apr;9(4):865. Kambay, M [corrected to Kanbay, M]]. Am J Transplant. 2008;8(11):2378-90. https://doi.org/10.1111/j.1600-6143.2008.02408.x PMid:18925905 DOI: https://doi.org/10.1111/j.1600-6143.2008.02408.x

Saunders IM, Tan M, Koura D, Young R. Long-term follow-up of hematopoietic stem cell transplant survivors: A focus on screening, monitoring, and therapeutics. Pharmacotherapy. 2020;40(8):808-41. https://doi.org/10.1002/phar.2443 PMid:32652612 DOI: https://doi.org/10.1002/phar.2443

Santoro N, Ruggeri A, Labopin M, Bacigalupo A, Ciceri F, Gülbaş Z, et al. Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: A study on behalf of the Acute Leukemia Working Party of the EBMT. J Hematol Oncol. 2017;10(1):113. https://doi.org/10.1186/s13045-017-0480-5 PMid:28558762 DOI: https://doi.org/10.1186/s13045-017-0480-5

Yang B, Yu R, Cai L, Guo B, Chen H, Zhang H, et al. Haploidentical versus matched donor stem cell transplantation for patients with hematological malignancies: A systemic review and meta-analysis. Bone Marrow Transplant. 2019;54(1):99-122. https://doi.org/10.1038/s41409-018-0239-9 PMid:29988061 DOI: https://doi.org/10.1038/s41409-018-0239-9

Meybodi MA, Cao W, Luznik L, Bashey A, Zhang X, Romee R, et al. HLA-haploidentical vs matched-sibling hematopoietic cell transplantation: a systematic review and meta-analysis. Blood Adv. 2019;3(17):2581-5. https://doi.org/10.1182/bloodadvances.2019000614 PMid:31484635 DOI: https://doi.org/10.1182/bloodadvances.2019000614

Wieduwilt MJ, Metheny L, Zhang MJ, Wang HL, Estrada-Merly N, Marks DI, et al. Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia. Blood Adv. 2022;6(1):339-57. https://doi.org/10.1182/bloodadvances.2021004916 PMid:34547770 DOI: https://doi.org/10.1182/bloodadvances.2021004916

Rafiee M, Abbasi M, Rafieemehr H, Mirzaeian A, Barzegar M, Amiri V, et al. A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes. Health Sci Rep. 2021;4(2):e282. https://doi.org/10.1002/hsr2.282 PMid:33977164 DOI: https://doi.org/10.1002/hsr2.282

Barban JB, Simões BP, Moraes BD, et al. Brazilian nutritional consensus in hematopoietic stem cell transplantation: Adults. Einstein (Sao Paulo). 2020;18:AE4530. https://doi:10.31744/einstein_journal/2020AE4530 PMid:32049129 DOI: https://doi.org/10.31744/einstein_journal/2020AO5075

Hingorani S, Pao E, Stevenson P, Schoch G, Laskin BL, Gooley T, et al. Changes in glomerular filtration rate and impact on long-term survival among adults after hematopoietic cell transplantation: A prospective cohort study. Clin J Am Soc Nephrol. 2018;13(6):866-73. https://doi.org/10.2215/CJN.10630917. PMid:29669818 DOI: https://doi.org/10.2215/CJN.10630917