Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index

Authors

  • Dina Keumala Sari Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-1442-5304
  • M. Ichwan Department of Pharmacology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Dewi Masyithah Department of Parasitology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Ridha Dharmajaya Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Alfi Khatib Kulliyah of Pharmacy, International Islamic University Malaysia, Selangor, Malaysia

DOI:

https://doi.org/10.3889/oamjms.2022.9282

Keywords:

Appetite, Gender, Neuropeptide, Obesity, Orexigenic

Abstract

Background: 

One’s appetite has a role in controlling food intake and maintaining energy balance, but its effect on body metabolism related to obesity is still questionable. The purpose of this study was to determine the levels of neuropeptide Y in healthy people and to see differences in gender and anthropometric parameters. The hypothesis of this study was that there would be differences in neuropeptide Y levels in groups with gender and anthropometric parameter differences. 

 

 

Methods:  

This study was a cross-sectional study involving 62 study subjects, male and female, who did not have chronic diseases or metabolic disorders. This research was conducted from April to September 2020. The parameters examined in this study were neuropeptide Y levels and anthropometric parameters. The statistical analysis performed was the Mann–Whitney test to see the differences between groups. 

Results:  

The mean age of the research subjects was 40.48 ± 10.85 years, with the same ethnic distribution. The distribution of men and women was more women than men. Based on anthropometric examination, it was found that obesity nutritional status was more common in the female group than in the male group; however, serum neuropeptide Y levels were found to be significantly different between male and female groups (male group was higher) which were mean±standard deviation: 348.37±330.09 ng/L, p=0.036. 

Conclusions: The study found significant differences in serum neuropeptide Y levels in male and female groups, with neuropeptide Y levels being higher in men than in women. 

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References

Gumbs MC, Eggels L, Kool T, Unmehopa UA, van den Heuvel JK, Lamuadni K, et al. Neuropeptide Y signaling in the lateral hypothalamus modulates diet component selection and is dysregulated in a model of diet-induced obesity. Neuroscience. 2019;447:28-40. https://doi.org/10.1016/j.neuroscience.2019.12.014 PMid:31887359

Meneguetti BT, Cardoso MH, Ribeiro CF, Felício MR, Pinto IB, Santos NC, et al. Neuropeptide receptors as potential pharmacological targets for obesity. Pharmacol Ther. 2019;196:59-78. https://doi.org/10.1016/j.pharmthera.2018.11.002 PMid:30439454

Wu Y, He H, Cheng Z, Bai Y, Ma X. The role of neuropeptide Y and peptide YY in the development of obesity via gut-brain axis. Curr Protein Pept Sci. 2019;20(7):750-8. https://doi.org/10.2174/1389203720666190125105401 PMid:30678628

Zain SM, Mohamed Z, Jalaludin MY, Fauzi F, Hamidi A, Zaharan NL, et al. Comprehensive evaluation of the neuropeptide-Y gene variants in the risk of obesity: A case-control study and meta-analysis. Pharmacogenet Genomics. 2015;25(10):501-10. https://doi.org/10.1097/FPC.0000000000000164 PMid:26240981

Vahatalo LH, Ruohonen ST, Mäkelä S, Ailanen L, Penttinen AM, Stormi T, et al. Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons. Nutr Diabetes. 2015;5:e151.

Subramanian M, Jayakumar S, Richhariya S, Hasan G. Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila. BMC Neurosci. 2013;14:157. https://doi.org/10.1186/1471-2202-14-157 PMid:24350669

Kim NS, Ko MM, Cha MH, Oh SM, Bang OS. Age and sex dependent genetic effects of neuropeptide Y promoter polymorphism on susceptibility to ischemic stroke in Koreans. Clin Chim Acta. 2010;411(17-18):1243-7.

Bowles WR, Burke R, Sabino M, Harding-Rose C, Lunos S, Hargreaves KM. Sex differences in neuropeptide content and release from rat dental pulp. J Endod. 2011;37(8):1098-101. https://doi.org/10.1016/j.joen.2011.03.007 PMid:21763901

Allison SJ, Baldock PA, Enriquez RF, Lin E, During M, Gardiner EM, et al. Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis. J Bone Miner Res. 2009;24(2):294-304. https://doi.org/10.1359/jbmr.081013 PMid:18847327

Liu Y, Wu D, Qu MY, He JL, Yuan M, Zhao M, et al. Neuropeptide Y-mediated sex-and afferent-specific neurotransmissions contribute to sexual dimorphism of baroreflex afferent function. Oncotarget. 2016;7(40):66135-48. https://doi.org/10.18632/oncotarget.11880 PMid:27623075

Sanchez C, El Khoury A, Hassan M, Wegener G, Mathé AA. Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression. Behav Brain Res. 2018;351:93-103. https://doi.org/10.1016/j.bbr.2018.05.029 PMid:29857028

Park S, Mori R, Shimokawa I. The fat regulator neuropeptide Y and caloric restriction. Aging (Albany NY). 2017;9(11):2243-4. https://doi.org/10.18632/aging.101338 PMid:29207376

Lutz TA. Neuropeptide Y helps us to deposit fat in adipose tissue. Acta Physiol (Oxf). 2015;213(4):753-5. https://doi.org/10.1111/apha.12461 PMid:25641275

Lin X, Qi Q, Zheng Y, Huang T, Lathrop M, Zelenika D, et al. Neuropeptide Y genotype, central obesity, and abdominal fat distribution: The POUNDS LOST trial. Am J Clin Nutr 2015;102(2):514-9. https://doi.org/10.3945/ajcn.115.107276 PMid:26156739

Wang G, Williams CA, McConn BR, Cline MA, Gilbert ER. A high fat diet enhances the sensitivity of chick adipose tissue to the effects of centrally injected neuropeptide Y on gene expression of adipogenesis-associated factors. Comp Biochem Physiol A Mol Integr Physiol. 2017;211:49-55. https://doi.org/10.1016/j.cbpa.2017.06.006 PMid:28625910

Wang XJ, Xu SH, Liu L, Song ZG, Jiao HC, Lin H. Dietary fat alters the response of hypothalamic neuropeptide Y to subsequent energy intake in broiler chickens. J Exp Biol. 2017;220(4):607-14. https://doi.org/10.1242/jeb.143792 PMid:27903700

Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, et al. Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: A trait potential for the life-extending effect of calorie restriction. Aging Cell. 2017;16(2):339-48. https://doi.org/10.1111/acel.12558 PMid:28101970

Kim YJ, Bi S. Knockdown of neuropeptide Y in the dorsomedial hypothalamus reverses high-fat diet-induced obesity and impaired glucose tolerance in rats. Am J Physiol Regul Integr Comp Physiol. 2016;310(2):R134-42. https://doi.org/10.1152/ajpregu.00174.2015 PMid:26561644

Hassan AM, Mancano G, Kashofer K, Fröhlich EE, Matak A, Mayerhofer R, et al. High-fat diet induces depression-like behaviour in mice associated with changes in microbiome, neuropeptide Y, and brain metabolome. Nutr Neurosci. 2019;22(12):877-93. https://doi.org/10.1080/1028415X.2018.1465713 PMid:29697017

World Health Organization. The Asia-Pacific Perspective: Redefining Obesity and Its Intervention. Australia: Health Communications Australia Pte. Limited; 2000. Available form: https://apps.who.int/iris/handle/10665/206936. [Last accessed on 2021 Jun 25].

Kementerian Kesehatan RI. Angka Kecukupan Gizi bagi Bangsa Indonesia, K.K.R. Indonesia. Jakarta: Kementerian Kesehatan RI; 2019. p. 33.

Gan L, England E, Yang JY, Toulme N, Ambati S, Hartzell Dl, et al. A 72-hour high fat diet increases transcript levels of the neuropeptide galanin in the dorsal hippocampus of the rat. BMC Neurosci. 2015;16:51. https://doi.org/10.1186/s12868-015-0188-9 PMid:26260473

Lu Y, Van Bever HP, Lim TK, Kuan WS, Goh DY, Mahadevan M, et al. Obesity, asthma prevalence and IL-4: Roles of inflammatory cytokines, adiponectin and neuropeptide Y. Pediatr Allergy Immunol. 2015;26(6):530-6. https://doi.org/10.1111/pai.12428 PMid:26111352

Vahatalo LH, Ruohonen ST, Ailanen L, Savontaus E. Neuropeptide Y in noradrenergic neurons induces obesity in transgenic mouse models. Neuropeptides. 2016;55:31-7. https://doi.org/10.1016/j.npep.2015.11.088 PMid:26681068

Moreno-Herrera A, García A, Palos I, Rivera G. Neuropeptide Y1 and Y5 receptor antagonists as potential anti-obesity drugs. Current status. Mini Rev Med Chem. 2014;14(11):896-919. PMid:25355591

Sitticharoon C, Chatree S, Churintaraphan M. Expressions of neuropeptide Y and Y1 receptor in subcutaneous and visceral fat tissues in normal weight and obese humans and their correlations with clinical parameters and peripheral metabolic factors. Regul Pept. 2013;185:65-72. https://doi.org/10.1016/j.regpep.2013.06.015 PMid:23838112

Yonaha H, Minoura H, Yoshida T, Takeuchi S, Noda N, Tanaka K, et al. Expression of neuropeptide Y is increased in murine endometrial epithelium during the peri-implantation period under regulation by sex steroids. Reprod Fertil Dev. 2004;16(3):355-61. https://doi.org/10.10371/RD02088 PMid:15304209

Qin Q, Chen P, Cui Z, Wang J, Xie B, Zhang S, et al. Neuropeptide Y knockdown in the dorsomedial hypothalamus improved basal and obesity-induced decrease in bone mass density. Neuro Endocrinol Lett. 2019;40(6):289-96. PMid:32200588

Koo BK, Kim SW, Yi KH, Park KS, Moon MK. Changing relative contribution of abdominal obesity and a family history of diabetes on prevalence of diabetes mellitus in Korean men and women aged 30-49 years from 2001 to 2010. J Diabetes. 2015;7(4):465-72. https://doi.org/10.1111/1753-0407.12202 PMid:25047371

Chan KS, Lai LK, Chan PF, Chao DV. Sudden-onset rash on the trunk and limbs. Morbid obesity. Family history of diabetes mellitus Dx? J Fam Pract. 2019;68(2):109-12. PMid:30870536

Lowe MR, Shank LM, Mikorski R, Butryn ML. Personal history of dieting and family history of obesity are unrelated: Implications for understanding weight gain proneness. Eat Behav. 2015;17:144-8. https://doi.org/10.1016/j.eatbeh.2015.01.002 PMid:25725461

Reuter CP, Burgos MS, Bernhard JC, Tornquist D, Klinger EI, Borges TS, et al. Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity. J Pediatr (Rio J). 2016;92(5):493-8. https://doi.org/10.1016/j.jped.2015.11.005 PMid:27154418

Saunders TJ, Tremblay MS, Mathieu ME, Henderson M, O’Loughlin J, Tremblay A, et al. Associations of sedentary behavior, sedentary bouts and breaks in sedentary time with cardiometabolic risk in children with a family history of obesity. PLoS One. 2013;8(11):e79143. https://doi.org/10.1371/journal.pone.0079143 PMid:24278117

Corica D, Aversa T, Valenzise M, Messina MF, Alibrandi A, De Luca F, et al. Does family history of obesity, cardiovascular, and metabolic diseases influence onset and severity of childhood obesity? Front Endocrinol (Lausanne). 2018;9:187. https://doi.org/10.3389/fendo.2018.00187 PMid:29770124

Romero-Ibarguengoitia ME, Vadillo-Ortega F, Caballero AE, Ibarra-González I, Herrera-Rosas A, Serratos-Canales MF, et al. Correction: Family history and obesity in youth, their effect on acylcarnitine/aminoacids metabolomics and non-alcoholic fatty liver disease (NAFLD). Structural equation modeling approach. PLoS One. 2018;13(5):e0198379. https://doi.org/10.1371/journal.pone.0193138 PMid:29466466

Sull JW, Kim S, Jee SH. Effects of obesity and family history of diabetes on the association of CETP rs6499861 with HDL-C level in korean populations. J Lipid Atheroscler. 2019;8(2):252-7. https://doi.org/10.12997/jla.2019.8.2.252 PMid:32821715

Nahvi RJ, Sabban EL. Sex differences in the neuropeptide Y system and implications for stress related disorders. Biomolecules. 2020;10(9):1248. https://doi.org/10.3390/biom10091248 PMid:32867327

Rugarn O, Hammar M, Theodorsson A, Theodorsson E, Stenfors C. Sex differences in neuropeptide distribution in the rat brain. Peptides. 1999;20(1):81-6. https://doi.org/10.1016/s0196-9781(98)00139-9 PMid:10098627

Senthilkumar R, Srinivasan R. Sex-specific spatial and temporal gene expressions of Pheromone biosynthesis activating neuropeptide (PBAN) and binding proteins (PBP/OBP) in Spoladea recurvalis. Sci Rep. 2019;9(1):3515. https://doi.org/10.1038/s41598-019-39822-x PMid:30837549

Mele P, Zammaretti F, Longo A, Panzica G, Oberto A, Eva C, et al. Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in leptin treated obese (ob/ ob) or lean mice. Brain Res. 2016;1649:102-9. https://doi.org/10.1016/j.brainres.2016.07.022 PMid:27425429

Painsipp E, Herzog H, Sperk G, Holzer P. Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y. Br J Pharmacol. 2011;163(6):1302-14. https://doi.org/10.1111/j.1476-5381.2011.01326.x PMid:21410462

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Published

2022-03-17

How to Cite

1.
Sari DK, Ichwan M, Masyithah D, Dharmajaya R, Khatib A. Sex Differences in Neuropeptide Y Serum, But Not in Fat Intake and Body Mass Index. Open Access Maced J Med Sci [Internet]. 2022 Mar. 17 [cited 2022 Jul. 1];10(T7):23-9. Available from: https://oamjms.eu/index.php/mjms/article/view/9282

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