Platelet to Lymphocytes Ratio to Predict Nasopharyngeal Carcinoma Progressivity

Authors

  • Goesti Yudistira Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia https://orcid.org/0000-0002-5217-3291
  • Yussy Afriani Dewi Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
  • Melati Sudiro Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9659

Keywords:

Nasopharyngeal carcinoma, Platelet to lymphocyte ratio, Clinical stage

Abstract

BACKGROUND: Nasopharyngeal carcinoma (NPC) is a head and neck cancer that arises from the nasopharyngeal epithelium. It is one of the most common malignancies in Southeast Asia. In 2020, there were 133,354 new cases of NPC worldwide, with 113,659 occurring on the Asian continent (85.2%). In Indonesia, the prevalence of NPC is 6.2/100,000 people, with 13,000 new cases each year. NPC was the most frequent head and neck cancer in the Otorhinolaryngology-Head and Neck Surgery Department Dr. Hasan Sadikin Hospital Bandung from 2013 to 2018, with 921 (35.20%) new cases.

AIM: Platelet-to-lymphocyte-ratio (PLR) testing has the potential to be employed as a prognostic marker in the evaluation of NPC. The purpose of this study is to investigate the link between PLR and the clinical stage of NPC.

METHODS: Between 2016 and 2020, a cross-sectional study was conducted on NPC patients at Hasan Sadikin Hospital in Bandung. Patient information was gathered from the registry of the Oncology Head and Neck Surgery Study Group. Three hundred and eighty-three people met the requirements for inclusion.

RESULTS: Lymph node metastases (p = 0.001), distant metastases (p = 0.001), and clinical stage (p < 0.001) are all classified differently by PLR. The platelet to lymphocytes ratio was linked to lymph node metastasis, distant metastases, and clinical stage in a statistically significant (p < 0.05). Patients with a PLR >287 have a 3.69 times chance of developing distant metastases, while those with a PLR >160 have a 1.38 times chance of progressing to the advanced stage.

CONCLUSION: PLR is linked to the nasopharyngeal cancer clinical stage. Furthermore, in NPC patients, PLR can predict advanced stage and distant metastases.

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References

Cen RX, Li YG. Platelet-to-lymphocyte ratio as a potential prognostic factor in nasopharyngeal carcinoma: A meta-analysis. Medicine (Baltimore). 2019;98(38):e17176. https://doi.org/10.1097/MD.0000000000017176 PMid:31567957 DOI: https://doi.org/10.1097/MD.0000000000017176

Chen YP, Chan AT, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64-80. https://doi.org/10.1016/S0140-6736(19)30956-0 PMid:31178151 DOI: https://doi.org/10.1016/S0140-6736(19)30956-0

Moore KL, Dalley AF, Agur AM. Moore Clinically Oriented Anatomy. 8th ed. Toronto: Wolters Kluwer; 2018.

International Agency for Research on Cancer. Cancer Fact Sheets-Nasopharynx. GLOBOCAN 2020. France: World Health Organization; 2021. p. 1-5.

Komite Penanggulangan Kanker Nasional. Komite Penanggulangan Kanker Nasional. Kanker Nasofaring. Indonesia: Kementerian Kesehatan Republik Indonesia; 2017.

Nathania N, Dewi YA, Permana AD. Profile of head neck cancer patients from 2013-2018 at Dr. Hasan Sadikin General hospital Bandung. Oto Rhinolaryngol Indones. 2020;51(2):141-5. DOI: https://doi.org/10.32637/orli.v50i2.361

Madani D. Prevalensi Penderita Karsinoma Nasofaring di Departemen THT-KL FK Unpad/RSUP Dr. Hasan Sadikin Bandung Periode 2010-2014. Indonesia: Fakultas Kedokteran Universitas Padjadjaran, (Tesis); 2014.

Hashim D, Boffetta P. NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers. Plymouth Meeting, Pennsylvania: National Comprehensive Cancer Network; 2020.

Lu A, Li H, Zheng Y, Tang M, Li J, Wu H, et al. Prognostic significance of neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, and platelet to lymphocyte ratio in patients with nasopharyngeal carcinoma. Biomed Res Int. 2017;2017:3047802. https://doi.org/10.1155/2017/3047802 PMid:28321405 DOI: https://doi.org/10.1155/2017/3047802

Chen S, Guo J, Feng C, Ke Z, Chen L, Pan Y. The preoperative platelet-lymphocyte ratio versus neutrophil-lymphocyte ratio: Which is better as a prognostic factor in oral squamous cell carcinoma? Ther Adv Med Oncol. 2016;8(3):160-7. https://doi.org/10.1177/1758834016638019 PMid:27239234 DOI: https://doi.org/10.1177/1758834016638019

Cui X, Jia Z, Chen D, Xu C, Yang P. The prognostic value of the C-reactive protein to albumin ratio in cancer: An updated meta-analysis. Medicine (Baltimore). 2020;99(14):e19165. https://doi.org/10.1097/MD.0000000000019165 PMid:32243358 DOI: https://doi.org/10.1097/MD.0000000000019165

Hendry S, Salgado R, Gevaert T, Russel PA, John T, Thapa B, et al. Assessing tumor-infiltrating lymphocytes in solid tumors: A practical review for pathologists and proposal for a standardized method from the international immuno-oncology biomarkers working group: Part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors. Adv Anat Pathol. 2017;24(6):311-35. https://doi.org/10.1097/PAP.0000000000000161 PMid:28777143 DOI: https://doi.org/10.1097/PAP.0000000000000161

Diana D, Kusmardi. Tumor-infiltrating lymphocytes and their role in breast cancer. Maj Patol Indones. 2020;29(1):30-40. DOI: https://doi.org/10.55816/mpi.v29i1.405

Mahdavifar N, Ghoncheh M, Mohammadian-Hafshejani A, Khosravi B, Salehiniya H. Epidemiology and inequality in the incidence and mortality of nasopharynx cancer in Asia. Osong Public Health Res Perspect. 2016;7(6):360-72. https://doi.org/10.1016/j.phrp.2016.11.002 PMid:28053841 DOI: https://doi.org/10.1016/j.phrp.2016.11.002

Okekpa SI, Mydin RB, Mangantig E, Azmi NS, Zahari SN, Kaur G, et al. Nasopharyngeal carcinoma (NPC) risk factors: A systematic review and meta-analysis of the association with lifestyle, diets, socioeconomic and sociodemographic in the Asian region. Asian Pac J Cancer Prev. 2019;20(11):3505-14. https://doi.org/10.31557/APJCP.2019.20.11.3505 PMid:31759378 DOI: https://doi.org/10.31557/APJCP.2019.20.11.3505

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jermal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. https://doi.org/10.3322/caac.21660 PMid:33538338 DOI: https://doi.org/10.3322/caac.21660

Hardianti RA, Dewi YA, Utami RD. Risk factor of nasopharyngeal carcinoma Dr. Hasan Sadikin general hospital Bandung. Int J Nasopharyngeal Carcinoma. 2019;1(3):110-1. https://doi.org/10.32734/ijnpc.v1i03.2065 DOI: https://doi.org/10.32734/ijnpc.v1i03.2065

Li WZ, Lv SH, Liu GY, Liang H, Xia WX, Xiang YQ. Age-dependent changes of gender disparities in nasopharyngeal carcinoma survival. Biol Sex Differ. 2021;12(1):18. https://doi.org/10.1186/s13293-021-00361-8 PMid:33516267 DOI: https://doi.org/10.1186/s13293-021-00361-8

Zuo XY, Feng QS, Sun J, Wei PP, Chin YM, Guo YM, et al. X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma. Biol Sex Differ. 2019;10(1):13. https://doi.org/10.1186/s13293-019-0227-9 PMid:30909962 DOI: https://doi.org/10.1186/s13293-019-0227-9

Gihbid A, Benzeid R, Faouzi A, Nourlil J, Tawfiq N, Benchakroun N, et al. Circulating cell-free Epstein-Barr virus DNA levels and clinical features in Moroccan patients with nasopharyngeal carcinoma. Infect Agent Cancer. 2021;16(1):15. https://doi.org/10.1186/s13027-021-00353-8 PMid:33602309 DOI: https://doi.org/10.1186/s13027-021-00353-8

Ko JM, Tsang KH, Dai W, Choi SS, Leong MM, Ngan RK, et al. Leukocyte telomere length associates with nasopharyngeal carcinoma risk and survival in Hong Kong Chinese. Int J Cancer. 2018;143(9):2289-98. https://doi.org/10.1002/ijc.31617 PMid:29873071 DOI: https://doi.org/10.1002/ijc.31617

Berele BA, Cai Y, Yang G. Prognostic value of tumor infiltrating lymphocytes in nasopharyngeal carcinoma patients: Meta-analysis. Technol Cancer Res Treat. 2021;20:15330338211034265. https://doi.org/10.1177/15330338211034265 PMid:34323154 DOI: https://doi.org/10.1177/15330338211034265

Yang S, Zhao K, Ding X, Jiang H, Lu H. Prognostic significance of hematological markers for patients with nasopharyngeal carcinoma: A meta-analysis. J Cancer. 2019;10(11):2568-77. https://doi.org/10.7150/jca.26770 PMid:31258763 DOI: https://doi.org/10.7150/jca.26770

Majumdar S, Pathak S, Nandi D. Thymus: The site for development of cellular immunity. Resonance. 2018;23(2):197-217. https://doi.org/10.1007/s12045-018-0605-3 DOI: https://doi.org/10.1007/s12045-018-0605-3

Kurnianda J, Achmad AF, Hutajulu HS. Peripheral neutrophil to lymphocyte ratio is an independent prognostic factor in nasopharyngeal carcinoma patients. Indones J Cancer Control. 2021;1(2):44-9.

Chen Y, Sun J, Hu D, Zhang J, Xu Y, Feng H, et al. Predictive value of pretreatment lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio in the survival of nasopharyngeal carcinoma patients. Cancer Manag Res. 2021;13:8767-79. https://doi.org/10.2147/CMAR.S338394 PMid:34866938 DOI: https://doi.org/10.2147/CMAR.S338394

Anvari S, Osei E, Maftoon N. Interactions of platelets with circulating tumor cells contribute to cancer metastasis. Sci Rep. 2021;11(15477):15477. https://doi.org/10.1038/s41598-021-94735-y DOI: https://doi.org/10.1038/s41598-021-94735-y

Mattioli I. Immune circuits to shape natural killer cells in cancer. Cancers (Basel). 2021;13(13):3225. https://doi.org/10.3390/cancers13133225 PMid:34203391 DOI: https://doi.org/10.3390/cancers13133225

Dhatchinamoorthy K, Colbert JD, Rock KL. Cancer immune evasion through loss of MHC Class I antigen presentation. Front Immunol. 2021;12:636568. https://doi.org/10.3389/fimmu.2021.636568 PMid:33767702 DOI: https://doi.org/10.3389/fimmu.2021.636568

Kumarasamy C, Tirawy V, Sunil K, Suresh D, Shetty S, Muthukaliannan GK, et al. Prognostic utility of platelet-lymphocyte ratio, neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in head and neck cancers: A detailed PRISMA compliant systematic review and meta-analysis. Cancers (Basel). 2021;13(16):4166. https://doi.org/10.3390/cancers13164166 PMid:34439320 DOI: https://doi.org/10.3390/cancers13164166

Zeng X, Liu G, Pan Y, Li Y. Development and validation of immune inflammation-based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma. J Cell Mol Med. 2020;24(15):8326-49. https://doi.org/10.1111/jcmm.15097 PMid:32603520 DOI: https://doi.org/10.1111/jcmm.15097

Li Q, Yu L, Yang P, Hu Q. Prognostic value of inflammatory markers in nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era. Cancer Manag Res. 2021;13:6799- 810. https://doi.org/10.2147/CMAR.S311094 PMid:34512020 DOI: https://doi.org/10.2147/CMAR.S311094

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Published

2022-05-20

How to Cite

1.
Yudistira G, Dewi YA, Sudiro M. Platelet to Lymphocytes Ratio to Predict Nasopharyngeal Carcinoma Progressivity. Open Access Maced J Med Sci [Internet]. 2022 May 20 [cited 2024 Mar. 28];10(B):2189-94. Available from: https://oamjms.eu/index.php/mjms/article/view/9659