Effect of Dual Blockade of Renin-Angiotensin System on Proteinuria


  • Eqerem Hasani Service of Cardiology, UHC “Mother Teresa”, Tirana
  • Alma Idrizi Service of Nephrology, UHC “Mother Teresa”, Tirana
  • Myftar Barbullushi Service of Nephrology, UHC “Mother Teresa”, Tirana




dual blockade, renin-angiotensin system, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, proteinuria.


Aim: Aim of the study was the evaluation of the effect of dual blockade of the renin-angiotensin system (RAS) on proteinuria.

Material and Methods: Sixty patients, included in the study, were treated with angiotensin-converting enzyme inhibitor and angiotensin receptor blocker for a period of 3 months.

Results: The dual blockade of RAS resulted with decrease of proteinuria, a slight increase of serum creatinine and was not associated with a lowering of blood pressure.

Conclusion: Combined therapy with ACE-I and ARB results in a more complete blockade of the RAS than monotherapy. In proteinuric nephropathies it reduces significantly baseline proteinuria.


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How to Cite

Hasani E, Idrizi A, Barbullushi M. Effect of Dual Blockade of Renin-Angiotensin System on Proteinuria. Open Access Maced J Med Sci [Internet]. 2013 Dec. 15 [cited 2021 Apr. 12];1(1):18-20. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2013.004



B - Clinical Sciences