Treatment Algorithm for Chronic Anal Fissure – A Review of Literature and it’s Apply in University Clinical Center Mother Teresa – Skopje
DOI:
https://doi.org/10.3889/oamjms.2014.095Keywords:
fissure in ano, treatment algorithm, nifedipine and lidocaine, digital anal dilatation, botulinum toxin, lateral internal sphincterotomy.Abstract
Chronic anal fissure is one of the most frequent anorectal disorders. Symptoms vary but typically include bright red rectal bleeding, itching and discomfort or pain during and after defecation. Treatment has undergone a transformation in recent years from surgical to medical, all approaches sharing the goal of reducing the spasm.
According to the researched treatment guidelines and the experience at the “University Clinical Center Mother Teresa†(Clinic of Gastroenterohepatology and Clinic of Abdominal Surgery) in Skopje, Macedonia, we propose the following algorithm for treatment of chronic anal fissure in three steps: from topical nifedipine + lidocaine cream (first-line) to second course of nifedipine + lidocaine cream or digital anal dilatation or botulinum toxin type A injection (second-line) to lateral internal sphincterotomy (third-line).
The proposed treatment algorithm allows patients to start with the least invasive treatment. There is no doubt that patients are willing to try less invasive modalities with the hope of avoiding surgery, with its risk of permanent disability. It should be up to the patients to decide which treatment they prefer. Although chemical sphincterotomy is less successful from lateral internal sphincterotomy, the algorithm allows feasibility, efficacy and cost-effectiveness, as well as risk reduction for surgical morbidity.Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Sinha and Kaiser. Efficacy of management algorithm for reducing need for sphincterotomy in chronic anal fissure. Colorectal Disease. 2011; 14: 760-764. DOI: https://doi.org/10.1111/j.1463-1318.2011.02736.x
Cross KLR, Massey EJD, Fowler AL, Monson JRT. The Management of Anal Fissure: ACPGBI Position Statement. Colorectal Disease. 2008; 10 (Suppl. 3): 1-7. DOI: https://doi.org/10.1111/j.1463-1318.2008.01681.x
Lock MR, Thompson JPS. Fissure in ano: the initial management and prognosis. Br J Surgery. 1977; 64: 355-8. DOI: https://doi.org/10.1002/bjs.1800640516
Etzioni DA. Current management of anal fissure. Semin Colon Rectal Surg. 2011; 22:2-8. DOI: https://doi.org/10.1053/j.scrs.2010.09.010
Martin JD. Postpartum anal fissure. Lancet. 1953; 1: 271-273. DOI: https://doi.org/10.1016/S0140-6736(53)90939-8
Nelson RL, Thomas K, Morgan J, Jones A. Non surgical therapy for anal fissure. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.: CD003431. DOI: 10.1002/14651858.CD003431.pub3. DOI: https://doi.org/10.1002/14651858.CD003431.pub3
Madoff RD, Fleshman JW. AGA technical review on the diagnosis and care of patients with anal fissure. Gastroenterology. 2003;124: 235-45. DOI: https://doi.org/10.1053/gast.2003.50005
Orsay C, Rakinic J, Perry WB et al. Practice parameters for the management of anal fissures (revised). Dis Colon Rectum. 2004; 47: 2003-7. DOI: https://doi.org/10.1007/s10350-004-0785-7
Lund JN, Binch C, McGrath J, Sparrow RA, Scholefield JH, Topographical distribution of blood supply to the anal canal. Br J Surg. 1999; 86: 496-8. DOI: https://doi.org/10.1046/j.1365-2168.1999.01026.x
Schouten WR, Briel JW, Auwerda JJ. Relationship between anal pressure and anodermal blood flow. The vascular pathogenesis of anal fissures. Dis Colon Rectum. 1994; 37: 664-9. DOI: https://doi.org/10.1007/BF02054409
Gupta PJ. A review of conservative and surgical management of anal fissure. Acta Gastroenterol Belg. 2005;68(4):446-50.
Haq Z, Rahman M, Chowdhury RA, Baten MA, Khatun M. Chemical sphincterotomy-first line of treatment for chronic anal fissure. Mymensingh Med J. 2005;14(1):88-90.
Lund JN, Nystrom PO, Coremans G et al. An evidence-based treatment algorithm for anal fissure. Tech Colproctol. 2006; 10:177-180. DOI: https://doi.org/10.1007/s10151-006-0276-z
Perrotti P, Bove A, Carmine A et al. Topical nifedipine with lidocaine ointment vs. active control for treatment of chronic anal fissure: results of a prospective, randomized, double-blind study. Dis Colon Rect. 2002; 45: 1468-75. DOI: https://doi.org/10.1007/s10350-004-6452-1
Perry WB, Dykes SL, Buie WD, et al. Practice Parameters for the Management of Anal Fissures (3rd Revision). Dis Colon Rectum. 2010; 53: 1110-5. DOI: https://doi.org/10.1007/DCR.0b013e3181e23dfe
Katsinelos P, Kountouras J, Paroutoglou G, et al. Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity. World J Gastroenterol. 2006; 12: 6203-6. DOI: https://doi.org/10.3748/wjg.v12.i38.6203
Watts JM, Bennett RC, Goligher JC. Stretching of anal sphincters in treatment of fissure-in-ano. Br Med J. 1964;2(5405):342-3. DOI: https://doi.org/10.1136/bmj.2.5405.342
McDonald A, Smith A, McNeill A, Finlay IG. Manual dilatation of the anus. Br J Surg. 1992; 79: 1381-2. DOI: https://doi.org/10.1002/bjs.1800791248
Hawley PR. The treatment of chronic fissure-in-ano. A trial of methods. Br J Surg. 1969; 56: 915–8. DOI: https://doi.org/10.1002/bjs.1800561212
Strugnell NA, Cooke SG, Lucarotti ME, Thomson WH. Controlled digital anal dilatation under total neuromuscular blockade for chronic anal fissure: a justifiable procedure. Br J Surg. 1999;86(5):651-5. DOI: https://doi.org/10.1046/j.1365-2168.1999.01128.x
Isbister WH, Prasad J. Fissure in ano. Aust N Z J Surg. 1995; 65:107-8. DOI: https://doi.org/10.1111/j.1445-2197.1995.tb07272.x
Jones OM, Moore JA, Brading AF, Mortensen NJ. Botulinum toxin injection inhibits myogenic tone and sympathetic nerve function in the porcine internal anal sphincter. Colorectal Dis. 2003; 5: 552-7. DOI: https://doi.org/10.1046/j.1463-1318.2003.00484.x
Tranqui P, Trottier DC, Victor C, Freeman JB. Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin. Can J Surg. 2006;49(1):41-5.
Lindsey I, Jones OM, Cunningham C, Mortensen NJMcC. Chronic anal fissure. Br J Surg. 2004; 91: 270-279. DOI: https://doi.org/10.1002/bjs.4531
Nyam DC, Pemberton JH. Long-term results of lateral internal sphincterotomy for chronic anal fissure with particular reference to incidence of fecal incontinence. Dis Colon Rectum. 1999;42: 1306–10. DOI: https://doi.org/10.1007/BF02234220
Garcea G, Sutton C, Mansoori S, Lloyd T, Thomas M. Results following conservative lateral sphincteromy for the treatment of chronic anal fissures. Colorectal Dis. 2003; 5: 311–4. DOI: https://doi.org/10.1046/j.1463-1318.2003.00465.x
Hyman N. Incontinence after lateral internal sphincterotomy: a prospective study and quality of life assessment. Dis Colon Rectum. 2004; 47: 35–8. DOI: https://doi.org/10.1007/s10350-003-0002-0
Porett TRC, Knowles CH, Lunniss PJ. Anal fissures in a district treatment algorithm for nurse-led management. Colorect Dis. 2002; 2002 (Suppl. 1):72.
Downloads
Published
How to Cite
Issue
Section
License
http://creativecommons.org/licenses/by-nc/4.0