Role of Vitamin D in Systemic Lupus Erythematosus

Rada Miskovic; Aleksandra Plavsic; Jasna Bolpacic; Sanvila Raskovic; Mirjana Bogic

doi:10.3889/oamjms.2014.119

Authors

Rada Miskovic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Aleksandra Plavsic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Jasna Bolpacic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Sanvila Raskovic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Mirjana Bogic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade

DOI:

https://doi.org/10.3889/oamjms.2014.119

Keywords:

vitamin D, systemic lupus erythematosus, immune system, biomarker, supplementation.

Abstract

Vitamin D is a steroid hormone that in addition to its well known role in the metabolism of calcium and phosphorus exerts immunoregulatory properties. Data from animal studies and from prospective clinical trials on patients with rheumatoid arthritis, multiple sclerosis and type 1 diabetes point to the potential role of vitamin D as important environmental factor in the development of autoimmune diseases. Such role of vitamin D in systemic lupus erythematosus (SLE) has not yet been sufficiently studied. This review shows the sources, metabolism and mechanism of action of vitamin D, its effect on the cells of the immune system, prevalence and causes of vitamin D deficiency in patients with SLE, the link between vitamin D status and disease activity as well as recommendations for vitamin D supplementation.

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