SjÃ¶grenâ€™s Syndrome and Silicosis â€“ a Case Report

Aleksandra Plavsic; Rada Miskovic; Jasna Bolpacic; Branka Å uÅ¡tran; Aleksandra Peric-Popadic; Mirjana Bogic

doi:10.3889/oamjms.2015.043

Authors

Aleksandra Plavsic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Rada Miskovic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Jasna Bolpacic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Branka Å uÅ¡tran Serbian Institute for Occupational Health "Dr Dragomir KarajoviÄ‡", Belgrade
Aleksandra Peric-Popadic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade
Mirjana Bogic Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade

DOI:

https://doi.org/10.3889/oamjms.2015.043

Keywords:

SjÃ¶grenâ€™s syndrome, autoimmune diseases, silica, silicosis, environmental factor

Abstract

SjÃ¶grenâ€™s syndrome is an autoimmune disease of unknown etiology where immune response to self-antigens is believed to result from interactions between genetic and environmental factors. We describe the case of a patient who has been diagnosed with SjÃ¶grenâ€™s syndrome based on typical clinical and immunological parameters. The clinical picture was dominated by the respiratory symptoms, and radiographic and multislice computed tomography examination of the chest showed certain changes characteristic of pneumoconiosis. Given that the patient has worked in a foundry where he has been exposed to the silica dust, he was subject to examination by occupational health specialists under the suspicion of lung silicosis, who confirmed the silicosis. This case report points to the possible connection between a professional exposure to silica and SjÃ¶grenâ€™s syndrome. Occupational exposure to silica is a possible risk factor for the development of autoimmune diseases, and in the evaluation of patients with connective tissue diseases it is important to consider work-related history.

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