Antiphospholipid Syndrome - A Case Report of Pulmonary Thromboembolism, Followed with Acute Myocardial Infarction in Patient with Systemic Sclerosis
DOI:
https://doi.org/10.3889/oamjms.2015.114Keywords:
systemic sclerosis, antiphospholipid syndrome, protrombotic state, pulmonary thromboembolism, myocardial infarctionAbstract
AIM: We are presenting an uncommon case of pulmonary embolism, followed with an acute myocardial infarction, in a patient with progressive systemic sclerosis.
CASE PRESENTATION: A female 40 years of age was admitted with signs of pulmonary embolism, confirmed with CT scan, which also reviled a thrombus in the right ventricle. The patient had medical history of systemic sclerosis since the age of 16 years. She suffered an ischemic stroke 6 years ago, but she was not taking any anticoagulant or antithrombotic medications ever since. She received a treatment with thrombolytic therapy, and subsequent UFH, but, on the second day after receiving fibrinolysis, she felt chest pain accompanied with ECG changes consistent for ST-segment elevation myocardial infarction (STEMI). Urgent coronary angiography was undertaken, which reviled cloths causing total occlusion in 4 blood vessels, followed with thromboaspiration, but without successful reperfusion. Several hours later the patient developed rapid deterioration with letal ending. During the very short hospital course, blood sampling reviled presence of antiphospholipid antibodies.
CONCLUSION: The acquired antiphospholipid syndrome is common condition in patients with systemic autoimmune diseases, but relatively rare in patients with systemic sclerosis. Never the less, we have to be aware of it when treating the patients with systemic sclerosis.Downloads
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Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306.
http://dx.doi.org/10.1111/j.1538-7836.2006.01753.x DOI: https://doi.org/10.1111/j.1538-7836.2006.01753.x
PMid:16420554
Keeling D, Mackie I, Moore GW, Greer IA, Greaves M; British Committee for Standards in Haematology. Guidelines on the investigation and management of antiphospholipid syndrome. Br J Haematol. 2012;157(1):47-58.
http://dx.doi.org/10.1111/j.1365-2141.2012.09037.x DOI: https://doi.org/10.1111/j.1365-2141.2012.09037.x
PMid:22313321
Saigal R, Kansal A, Mittal M, Singh Y, Ram H. Antiphospholipid antibody syndrome. J Assoc Physicians India. 2010;58:176-84.
PMid:20848817
Tincani A, Casu C, Cartella S, Ziglioli T, Cattaneo R. [Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations]. Reumatismo. 2010;62(1):65-75. DOI: https://doi.org/10.4081/reumatismo.2010.65
PMid:20390120
Rao V, Bowman S. Latest advances in connective tissue disorders. Ther Adv Musculoskelet Dis. 2013;5(4):234-49.
http://dx.doi.org/10.1177/1759720X13480280
PMid:23904866 PMCid:PMC3728978
Rao V, Bowman S. Latest advances in connective tissue disorders. Ther Adv Musculoskelet Dis. 2013;5(4):234-49.
http://dx.doi.org/10.1177/1759720X13480280 DOI: https://doi.org/10.1177/1759720X13480280
PMid:23904866 PMCid:PMC3728978
Bălănescu P, Lădaru A, Bălănescu E, Băicuş C, Dan GA. Association of anti phosphatidyl ethanolamine antibodies and low complement levels in systemic sclerosis patients--results of a cross-sectional study. Scand J Clin Lab Invest. 2015;75(6):476-81.
http://dx.doi.org/10.3109/00365513.2015.1050690 DOI: https://doi.org/10.3109/00365513.2015.1050690
PMid:26067612
Touré AO, Ly F, Sall A, Diatta A, Gadji M, Seck M, Faye B, Dieye T, Diop S. Antiphos-pholipid antibodies and systemic scleroderma. Turk J Haematol. 2013;30(1):32-6.
http://dx.doi.org/10.4274/tjh.2012.0059 DOI: https://doi.org/10.4274/tjh.2012.0059
PMid:24385750 PMCid:PMC3781654
Küçükşahin O, Ateş A, Okoh AK, Kulahcioglu E, Turgay M, Kınıklı G. Treatment resistant severe digital ischemia associated with antiphospholipid syndrome in a male patient with systemic sclerosis. Case Rep Rheumatol. 2014;2014:291382.
http://dx.doi.org/10.1155/2014/291382 DOI: https://doi.org/10.1155/2014/291382
Naoto F, Hashimoto T, Ozu Y, Komori S, Shomura Y, Fujiwara H, Nasu M, Okada Y. [Coronary artery bypass grafting in a patient with systemic lupus erythematosus, scleroderma and secondary antiphospholipid syndrome]. Kyobu Geka. 2011;64(13):1173-5.
PMid:22242296
Gupta R, Thabah MM, Gupta S, Shankar S, Kumar A. Clinical significance of an-tiphospholipid antibodies in Indian scleroderma patients. Rheumatol Int. 2009;30(2):277-9.
http://dx.doi.org/10.1007/s00296-009-1107-0 DOI: https://doi.org/10.1007/s00296-009-1107-0
PMid:19701755
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