Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes

Authors

  • Soha M. Abd El Dayem Pediatrics Department, National Research Centre, Cairo
  • Mona Abd El Kader Clinical Pathology Department, National Research Centre, Cairo
  • Soheir Ibrahim Pediatrics Department, Al-Azhar University, Cairo
  • Enas Mokhtar Pediatrics Department, National Research Centre, Cairo
  • Eman Abd El Megeed Pediatrics Department, Cairo

DOI:

https://doi.org/10.3889/oamjms.2017.033

Keywords:

Leptin, lipid profile, overweight, type 1 diabetic patient

Abstract

AIM: To evaluate leptin and lipid profile in overweight patients with type 1 diabetes.

PATIENTS AND METHODS: The study included 50 overweight patients with type 1 diabetes and 50 age and sex matched healthy controls. Blood samples were taken for evaluation of glycosylated haemoglobin, lipid profile and leptin. Also, urine samples were taken for evaluation of albumin/creatinine ratio.

RESULTS: Leptin level was significantly lower in overweight with type 1 diabetes and showed a significant positive correlation with hip circumference and body mass index and negative correlation with glycosylated haemoglobin (HbA1c). Leptin level was significantly lower in overweight diabetic patients with HbA1c > 7.5 %. The best cut-off point between overweight diabetic group and control group regarding leptin levels was found at 16.9 (ng/ml) with a sensitivity of 68% and specificity of 56%, area under the curve 0.623.

CONCLUSION: Leptin levels were found to be low in overweight patients with type 1 diabetes and showed correlation with the body mass index and hip circumference. LDL was significantly higher while HDL was significantly lower in the diabetic, overweight group indicating increased risk of cardiovascular disease. Leptin level in overweight diabetic patients might be related to the metabolic control.

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References

Fourlanos S, Harrison LC, Colman PG. The accelerator hypothesis and increasing incidence of type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2008;15:321–325. https://doi.org/10.1097/MED.0b013e3283073a5a PMid:18594271 DOI: https://doi.org/10.1097/MED.0b013e3283073a5a

Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA. 2010;303 (3): 242–249. https://doi.org/10.1001/jama.2009.2012 PMid:20071470 DOI: https://doi.org/10.1001/jama.2009.2012

Lin J, Glynn RJ, Rifai N, et al. Inflammation and progressive nephropathy in type 1 diabetes mellitus in the Diabetes Control and Complications Trial (DCCT). Diabetes Care. 2008; 31:2338–2343. https://doi.org/10.2337/dc08-0277 PMid:18796620 PMCid:PMC2584192 DOI: https://doi.org/10.2337/dc08-0277

Kratzsch J, Deimel A, Galler A, et al. Increased serum soluble leptin receptor levels in children and adolescents with type 1 diabetes mellitus. Eur J Endocrinol. 2004;151:475–481. https://doi.org/10.1530/eje.0.1510475 PMid:15476448 DOI: https://doi.org/10.1530/eje.0.1510475

Otero M, Lago R, Lago F, et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett. 2005; 579:295–301. https://doi.org/10.1016/j.febslet.2004.11.024 PMid:15642335 DOI: https://doi.org/10.1016/j.febslet.2004.11.024

Ghalli I, Salah N, Hussien F, Erfan M, ElRuby M, Mazen I, Sabry M, Abd El-Razik M, Saad M, Hossney L, Ismaail S and Abd El-Dayem S et al. (2003): In Proceedings of the 1st National Congress for Egyptian Growth Curves, Cairo University, 11 December 2003 in: Sartorio A, Buckler J.M.H and Marazzi N. Egyptian Growth Curves 2002 for Infants, Childrenand Adolescents. Crescere nel mondo, Ferring Publisher, 2008.

Tanner JM, Hiernaux J, Jarman S. Growth and physical studies. In: Weiner JS, Lourie JA, editors. Human biology: a guide to field methods. Oxford: Blackwell Scientific Publ, 1969: 3–41.

Cameron N. The methods of auxological anthropology. In: Falkner F, Tanner JM, editors. Human growth 3 Methodology. New York: Plenum Press, 1986:3–46. PMid:3956717 DOI: https://doi.org/10.1007/978-1-4615-7198-8_1

Trivelli LA, Ranney HM, Lai HT. Hemoglobin components in patients with diabetes mellitus. N Engl J Med. 1971;284:353–7. https://doi.org/10.1056/NEJM197102182840703 PMid:5539916 DOI: https://doi.org/10.1056/NEJM197102182840703

Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984;310:356–60. https://doi.org/10.1056/NEJM198402093100605 PMid:6690964 DOI: https://doi.org/10.1056/NEJM198402093100605

Marques-Vidal P, Ferrario M, Kuulasmaa K, Grafnetter D, Moltchanov V. WHO MONICA Project. Quality assessment of data on HDL cholesterol in the WHO MONICA Project, 1999. Available from: URL:http://www.thl.fi/publications/monica/ hdl/hdlqa.htm, URN:NBN:fi-fe19991137

Kirel B, Doğruel N, Korkmaz U, Kiliç FS, Ozdamar K, Uçar B. Serum leptin level in type 1 diabetic and obese children to relation to insulin level. Clin Biochem. 2000; 33(6):475-80. https://doi.org/10.1016/S0009-9120(00)00136-3 DOI: https://doi.org/10.1016/S0009-9120(00)00136-3

Abd El-Maksoud AM, El Hefnawy MH, Abdel-Ghaffar AR, Eskander EF, Ahmed HH, Seoudi DM, Yahya SM, Kamal IH. Adiponectin, leptin and lipid profile in type 1 diabetic children and adolescents. J Clin Lipidol. 2009; 3(4):269-74. https://doi.org/10.1016/j.jacl.2009.07.002 PMid:21291823 DOI: https://doi.org/10.1016/j.jacl.2009.07.002

Kratzsch J, Knerr I, Galler A, Kapellen T and Kiess W. Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor Eur J Endocrinol. 2006; 155:609-614. https://doi.org/10.1530/eje.1.02261 PMid:16990661 DOI: https://doi.org/10.1530/eje.1.02261

Verrotti A, Basciani F, Morgese G & Chiarelli F. Leptin levels in nonobese and obese children and young adults with type 1 diabetes mellitus. European Journal of Endocrinology. 1998; 139:49-53. https://doi.org/10.1530/eje.0.1390049 PMid:9703378 DOI: https://doi.org/10.1530/eje.0.1390049

Soliman AT, Omar M, Assem HM, Nasr IS, Rizk MM, El Matary W, El Alaily RK. Serum leptin concentrations in children with type 1 diabetes mellitus: relationship to body mass index, insulin dose, and glycemic control. Metabolism. 2002;51(3):292-6. https://doi.org/10.1053/meta.2002.30502 PMid:11887162 DOI: https://doi.org/10.1053/meta.2002.30502

Snell-Bergeon JK, Nancy A, West Elizabeth J, Mayer-Davis, Angela D, Liese Santica M, Marcovina Ralph B, D'Agostino JR, Richard F, Hamman and Dana Dabelea. Increased of Inflammatory Markers in Youth with Type 1 Diabetes: The SEARCH Case-Control Study. Clin Endocrinol Metab. 2010; 95(6): 2868–2876. https://doi.org/10.1210/jc.2009-1993 PMid:20371668 PMCid:PMC2902077 DOI: https://doi.org/10.1210/jc.2009-1993

Al Maskari, Masoud Y, Adel A Alnaqdy. Correlation between Serum Leptin Levels, Body Mass Index and Obesity in Omanis Sultan Qaboos Univ Med J. 2006; 6(2): 27–31. PMid:21748132

Nishimura R, Sano H, Matsudaira T, et al. Childhood obesity and its relation to serum adiponectin and leptin: A report from a population-based study. Diabetes Res Clin Pract. 2007; 76:245-50. https://doi.org/10.1016/j.diabres.2006.09.023 PMid:17118479 DOI: https://doi.org/10.1016/j.diabres.2006.09.023

Antunes H, Santos C and Carvalho S. Serum leptin levels in overweight children and adolescents. British Journal Nutr. 2009; 101: 1266. https://doi.org/10.1017/S0007114508055682 PMid:18755049 DOI: https://doi.org/10.1017/S0007114508055682

Moore SR, Falorini A, Bini V, Fulford AJC, O'Connell MA, Prentice AM. Ethnic differences in the relationship between fasting leptin and body mass index in children. Int J Obes Relat Metab Disord. 2004; 28:17-21. https://doi.org/10.1038/sj.ijo.0802484 PMid:14652620 DOI: https://doi.org/10.1038/sj.ijo.0802484

Laing SP, Swerdlow AJ, Carpenter LM, Slater SD, Burden AC, Botha JL, Morris AD, Waugh NR, Gatling W, Gale EA, Patterson CC, Qiao Z, Keen H. Mortality From Cerebrovascular Disease in a Cohort of 23 000 Patients With Insulin-Treated Diabetes. Stroke. 2003; 34:418-21. https://doi.org/10.1161/01.STR.0000053843.03997.35 PMid:12574553 DOI: https://doi.org/10.1161/01.STR.0000053843.03997.35

Dahl-Jorgensen K, Larsen JR, Hanssen KF. Atherosclerosis in childhood and adolescent type 1 diabetes: early disease, early treatment? Diabetologia. 2005; (48) 1445-1453. https://doi.org/10.1007/s00125-005-1832-1 PMid:15971059 DOI: https://doi.org/10.1007/s00125-005-1832-1

Margeirsdottir, HD, Larsen JR, Brunborg C, Overby NC, Dahl-Jorgensen K. High prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes: a population-based study. Diabetologia. 2008; (51): 554-561. https://doi.org/10.1007/s00125-007-0921-8 PMid:18196217 DOI: https://doi.org/10.1007/s00125-007-0921-8

Van Vliet, M, Van der Heyden JC, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, Veeze HJ. Over weight is highly prevalent in children with type 1 diabetes and associates with cardiometabolic risk. J Pediatr. 2010; 156, 923-929. https://doi.org/10.1016/j.jpeds.2009.12.017 PMid:20223481 DOI: https://doi.org/10.1016/j.jpeds.2009.12.017

Skrivarhaug T, Bangstad HJ, Stene LC, Sandvik L, Hanssen KF, Joner G. Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. Diabetologia. 2006; 49, 298-305. https://doi.org/10.1007/s00125-005-0082-6 PMid:16365724 DOI: https://doi.org/10.1007/s00125-005-0082-6

Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study. The American journal of cardiology. 2002;90: 3L-7L. https://doi.org/10.1016/S0002-9149(02)02953-3 DOI: https://doi.org/10.1016/S0002-9149(02)02953-3

Uttra KM, Devrajani BR, Shah ZA, Devrajani T, Das T, Raza S. Lipid Profile of Patients with Diabetes mellitus (A Multidisciplinary Study). World Appl Sci J. 2011; 12 (9):1382-1384.

Salem M, Moneir I, Adly AM, Esmat K. Study of coronary artery calcification risk in Egyptian adolescents with type-1 diabetes. Acta Diabetol. 2011; 48: 41-53. https://doi.org/10.1007/s00592-010-0214-4 PMid:20706852 DOI: https://doi.org/10.1007/s00592-010-0214-4

International Society of Pediatric and Adolescent Diabetes (ISPAD). consensus guideline for the definition, epidemiology, and classification of type 1 DM in children and adolescent. Pediatric Diabetes. 2007; (7): 343-351. DOI: https://doi.org/10.1111/j.1399-5448.2006.00216.x

Gunczler P, Lanes R, Soros A, Verdu L, Ramon Y, Guevara B, Beer N. Coronary artery calcification, serum lipids, lipoproteins, and peripheral inflammatory markers in adolescents and young adults with type 1 diabetes. J Pediatr. 2006; 149: 320-3. https://doi.org/10.1016/j.jpeds.2006.04.064 PMid:16939740 DOI: https://doi.org/10.1016/j.jpeds.2006.04.064

Hassan M, Mona, Sharaf A, Sahar, Soliman M, Hend , Al-Wakeel A, Nanees. Dyslipidemia in type 1 diabetes mellitus. Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU), New Children Hospital, Cairo University Egypt, 2015;(63): 63–68. DOI: https://doi.org/10.1016/j.epag.2015.03.001

Al-Naama LM, Kadhim M, Al-Aboud MS. Lipid profile in children with insulin dependent diabetes mellitus. JPMA. 2002;( 52):29-36.

Rahma S, Rashid JA, Farage AH. The significance of lipid abnormalities in children with insulin dependent diabetes mellitusIraqi Postgrad Med J. 2006; 5: 289–294.

Herman HW, Aubert RE, Engelgau MM, Thompson TJ, Ali MA, Sous ES et al. Diabetes mellitus in Egypt: glycaemic control and microvascular and neuropathic complications. Diabet Med. 1998; 15: 1045–1051. https://doi.org/10.1002/(SICI)1096-9136(1998120)15:12<1045::AID-DIA696>3.0.CO;2-L DOI: https://doi.org/10.1002/(SICI)1096-9136(1998120)15:12<1045::AID-DIA696>3.0.CO;2-L

Kantoosh MM, Naiem AM, El-Sayad M, Nashat M. Dyslipidemia and lipid peroxidation in type 1 diabetic children with good glycemic control: response to antioxidant therapy. Alex J Pediatr. 2002; 16: 357–364.

Patiakas S, Kiriakopoulos N, Gavala C, Aggos I, Akritopoulou K, Akritopoulos P, Xiropoulou E. The lipid profile of patients with diabetes mellitus in Paionia country. Diabetol Stoffwechs. 2007; (2): A35. DOI: https://doi.org/10.1055/s-2007-984781

Alrabaty AA, Alnakshabandi AA, Yahya NB. The lipid profile in children with type 1 diabetes mellitus in Erbil governorate. Iraqi Postgrad Med J. 2009; 8 : 344–349.

Maahs DM, Wadwa RP, McFann K, Nadeau K, Williams MR, Eckel RH, Klingensmith GJ. Longitudinal lipid screening and use of lipid-lowering medications in pediatric type 1 diabetes. J Pediatr. 2007;150(2):146-50, 150.e1-2. DOI: https://doi.org/10.1016/j.jpeds.2006.10.054

Hamad A, Qureshi Hj. Dyslipidaemia in recently diagnosed young subjects of type 1 diabetes mellitus with normal/favourable bmi: a risk factor of macrovascular disease. Biomedica. 2008;24.

Guy JL, Ogden RP, Wadwa RF, Hamman EJ, Mayer-Davis AD, Liese R, D'Agostino S, Marcovina D, Dabelea. Lipid and lipoprotein profiles in youth with and without type 1 diabetes. Diabetes Care. 2009;32: 416–420. https://doi.org/10.2337/dc08-1775 PMid:19092167 PMCid:PMC2646019 DOI: https://doi.org/10.2337/dc08-1775

Kanagalakshmi KM, Sultana A. Preliminary study of lipid profiles in pediatric population and youth population with type 1 diabetes. Int J Pharm Biol Sci. 2012; 3: 828–832.

Moayeri H, Oloomi Z. Prevalence of dyslipidemia in children and adolescents with diabetes mellitus type I. Iran J Pediatr. 2006; 16: 171–176.

Schwab KO, Doerfer J, Hecker W, Grulich-Henn J, Wiemann D, Kordonouri O, Beyer P, Holl RW. Spectrum and prevalence of atherogenic risk factors in 27,358 children, adolescents and young adults with type 1 diabetes Diabetes Care. 2006; 29 : 218–225. https://doi.org/10.2337/diacare.29.02.06.dc05-0724 PMid:16443863 DOI: https://doi.org/10.2337/diacare.29.02.06.dc05-0724

Ladeia AM, Adan L, Couto-Silva AC, Hiltner Â, Guimarães AC. Lipid profile correlates with glycemic control in young patients with type 1 diabetes mellitus. Prev Cardiol. 2006; 9:82–88. https://doi.org/10.1111/j.1520-037X.2006.4019.x PMid:16603826 DOI: https://doi.org/10.1111/j.1520-037X.2006.4019.x

Wiltshire EJ, Hirte C, Couper JJ. Dietary fats do not contribute to hyperlipidemia in children and adolescents with type 1 diabetes. Diabetes Care. 2003; 26: 1356–1361. https://doi.org/10.2337/diacare.26.5.1356 PMid:12716788 DOI: https://doi.org/10.2337/diacare.26.5.1356

Krantz JS, Mack WJ, Hodis HN, Liu CR, Liu CH, Kaufman FR. Early onset of subclinical atherosclerosis in young persons with type 1 diabetes. J Pediatr. 2004; 145: 452–457. https://doi.org/10.1016/j.jpeds.2004.06.042 PMid:15480366 DOI: https://doi.org/10.1016/j.jpeds.2004.06.042

AL-Suhaimi EA, AL-Kulaifi FM, Ravinayagam V, Al-Qahtani MH. Serum Adipocytokines, Metabolic and Immunological Correlations in Type 1 Diabetes mellitus (T1DM) Children. The Open Endocrinology Journal. 2012;6(1). DOI: https://doi.org/10.2174/1874216501106010110

Muchacka-Bianga M, Deja G, Jarosz-Chobot P, Małecka-Tendera E, Kalina M, Grychtoł M. Evaluation of selected risk factors of atherosclerosis in children with type 1 diabetes mellitus and hypercholesterolemia. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12 :25–30. PMid:16704858

Teles SA, Fornés NS. Relationship between anthropometric and biochemical profiles in children and adolescents with type 1 diabetes. Rev Paul Pediatr. 2012; 30: 65–71. https://doi.org/10.1590/S0103-05822012000100010 DOI: https://doi.org/10.1590/S0103-05822012000100010

Published

2017-03-19

How to Cite

1.
Abd El Dayem SM, Abd El Kader M, Ibrahim S, Mokhtar E, Abd El Megeed E. Leptin and Lipid Profile in Overweight Patient with Type 1 Diabetes. Open Access Maced J Med Sci [Internet]. 2017 Mar. 19 [cited 2024 Mar. 28];5(2):131-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2017.033

Issue

Section

A - Basic Science

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