Study of Visfatin Level in Type 1 Diabetic Children and Adolescents

Mona H. El Samahi; Nagwa Abdallah Ismail; Randa M. Matter; Abeer Selim; Alshaymaa Ahmed Ibrahim; Walaa Nabih

doi:10.3889/oamjms.2017.065

Authors

Mona H. El Samahi Pediatrics Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, Cairo
Nagwa Abdallah Ismail Pediatrics Department, National Research Centre, Cairo
Randa M. Matter Pediatrics Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, Cairo
Abeer Selim Pediatrics Department, National Research Centre, Cairo http://orcid.org/0000-0003-1952-4341
Alshaymaa Ahmed Ibrahim Clinical Pathology Department, National Research Centre, Cairo
Walaa Nabih Pediatrics Department, National Research Centre, Cairo

DOI:

https://doi.org/10.3889/oamjms.2017.065

Keywords:

Type 1 diabetes, Visfatin, complications, microalbuminuria

Abstract

BACKGROUND: Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels.

AIM: The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications.

MATERIAL AND METHODS: Fifty children and adolescents with type 1 diabetes mellitus were recruited with 30 ages and gender-matched healthy subjects. They were subjected to history taking; anthropometric measurements and chronic diabetic complications were recorded if present. Laboratory analysis included urinary microalbumin, serum triglycerides, HDL, LDL, cholesterol, fasting blood glucose, glycosylated Hb (HbA1c) and serum visfatin which was measured with enzyme-linked immunosorbent assay.

RESULTS: Diabetic patients showed highly significant decrease in the level of visfatin compared to the control group (P = 0.0001).There was significant further decrease in visfatin level in diabetics with microalbuminuria (n = 13) compared to normoalbuminuric patients (n = 37) (P = 0.015). There was highly significant inverse correlation between visfatin level with age (r = -0.379, p = 0.007), BMI (r = -0.418, p = 0.003), waist circumference (r = -0.430, p = 0.002), hip circumference (r = -0.389, p = 0.005) and microalbuminuria (r = -0.323, p = 0.022).

CONCLUSIONS: Type 1 diabetic children and adolescents had a significantly lower visfatin level compared to controls. A marked decrease in the level of visfatin was shown in patients with microalbuminuria with an inverse correlation with BMI suggesting an important role of visfatin in the pathogenesis of type 1 diabetics and type 1 diabetic nephropathy.

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Author Biographies

Mona H. El Samahi, Pediatrics Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, Cairo

Professor of Pediatrics, Pediatric Department.

Walaa Nabih, Pediatrics Department, National Research Centre, Cairo

Research assisstant, Â Pediatric Department, Medical Research Division.

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