Correlation between Serum Homocysteine and Vitiligo Area Scoring Index

Dina R. U. Hasibuan; Imam B. Putra; Nelva K. Jusuf

doi:10.3889/oamjms.2017.066

Authors

Dina R. U. Hasibuan Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, North Sumatera http://orcid.org/0000-0001-5915-9663
Imam B. Putra Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, North Sumatera
Nelva K. Jusuf Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, North Sumatera

DOI:

https://doi.org/10.3889/oamjms.2017.066

Keywords:

Vitiligo, serum homocysteine, pathogenesis

Abstract

Background: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity.Â

Aim : To determine correlation between serum homocysteine and vitiligo area scoring index (VASI)

Subject and method: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Woodâ€™s lamp examinations then VASI score was determined and same numbers of control. We conducted blood sampling and measurement of serum homocysteine level to the patients.

Results: There is no significant correlation between serum homocysteine and VASI score (p= 0,133, r= 0,281), family history (p=0,447), and duration of vitiligo (p= 0,993, r= 0,002). There is no significant difference between serum homocysteine in vitiligo patients and controls (p= 0,191). There is a correlation between serum homocysteine with gender (p= 0,001) and age (p= 0,036;r= 0,385) Â in vitiligo patient but not in controls (p= 0,266), (p= 0,872; r= 0,031). There is a correlation between serum homocysteine and types of vitiligo.

Â

Conclusion: There is no significant correlation between serum homocysteine and VASI score, family history, and duration of vitiligo. There is no significant difference between serum homocysteine in vitiligo patients and controls. There is a correlation between serum homocysteine with gender and age in vitiligo patients.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

Author Biography

Nelva K. Jusuf, Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, North Sumatera

Lecturer inÂ Department of Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia

References

Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: A comprehensive overview part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65:473-91. https://doi.org/10.1016/j.jaad.2010.11.061 PMid:21839315

Birlea SA, Spritz RA, Noris DA. Vitiligo. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, Wolff K,editors. Fitzpatrick's dermatology in general medicine. 8th ed. New York: The MCGraw-Hill companies, 2012: p. 1308-24.

Yaghoobi R, Omidian M, Bagherani N. Vitiligo: A review of the published work. Journal of Dermatology. 2011;38:419-31. https://doi.org/10.1111/j.1346-8138.2010.01139.x PMid:21667529

Karadag AS, Tutal E, Ertugrul DT, Akint KO, Bilgili SG. Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in patients with vitiligo. Clin Exp Dermatol. 2011; 37: 62-4. https://doi.org/10.1111/j.1365-2230.2011.04142.x PMid:22182436

Bolander-Gouaille C. Homocysteine, the new marker of disease risk-an overview. Business briefing: European pharmacotherapy. 2005;2-8.

Agarwal S, Mendiratta V, Chander R, Jain A, Yadav P. Study of serum levels of Vitamin B, folic acid, and homocysteine in vitiligo. Pigment Int. 2015;2:76-80. https://doi.org/10.4103/2349-5847.172777

Elhuda. Hubungan kadar homosistei serum dengan skor vitiligo area scoring index (VASI) . Sp. DV [ Tesis]. Padang: Universitas Andalas, 2016.

Zaki AM, Abdo HM, Ibrahim IM, Ibrahim AEKI. Serum homocysteine and vitiligo. The gulf journal of dermatology and venereology. 2014 ;21(2): 15-20.

El-Dawela RE, Abou-elfetouh S. Relationship between homocysteine, vitamin B12, folic acid levels and vitiligo. J Appl Sci Res. 2012; 8(11): 5528-35.

Sabry HH, Sabry JH, Hashim HM. Serum levels of homocysteine, vitamin B12, and folic acid in vitiligo. Egypt J Dermatol Venerol. 2014;34:65-9. https://doi.org/10.4103/1110-6530.137315

Becatti M, Prigano F, Fiorillo, Pescitelli L, Nassi P, Lotti T, Taddei N.The involvement of Smac/DIABLO, p53, NF-kB, and MAPK pathways in apoptosis of keratinocytes from perilesional vitiligft skin: protective effects of curcumin and capsaicin. Antioxidants & Redox Signaling. 2010; 13(9):1309-21. https://doi.org/10.1089/ars.2009.2779 PMid:20085492

Yu H, Chang K, Yu C, Li H, Wu M, Wu C,et al. Alterations in IL-6, IL-8, GM-CSF, TNF-a, and IFNy release by peripheral mononuclear cells in patients with active vitiligo. J invest Dermatol. 1997;108: 527 -9. https://doi.org/10.1111/1523-1747.ep12289743 PMid:9077486

Ghalamkarpour F Jafarian Z, Einollahi H, Younespour S. Homocysteine: is it a biomarker for vitiligo? Journal of pigmentary disorders. 2015; 2(4): 1-4.

Silverberg JI, Silverberg NB. Serum homocysteine as a biomarker of vitiligo vulgaris severity: A pilot study. J Am Acad Dermatbl. 2011. 64(2):445-7. https://doi.org/10.1016/j.jaad.2010.08.025 PMid:21238838

Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999; 19:217-46. https://doi.org/10.1146/annurev.nutr.19.1.217 PMid:10448523

Singh S, Singh U, Pandey SS. Serum folic acid, vitamin B12 and homocysteine levels in Indian vitiligo patients. EDOJ. 2012; 8(1):1-7.