Correlation between Serum Leptin Level with Type and Number of Lesion Skin Tag

Authors

  • Imam Budi Putra Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, General Hospital of Universitas Sumatera Utara, Medan, Indonesia
  • Remenda Siregar Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, General Hospital of Universitas Sumatera Utara, Medan, Indonesia
  • Nelva K. Jusuf Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, General Hospital of Universitas Sumatera Utara, Medan, Indonesia
  • Oratna Ginting Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, General Hospital of Universitas Sumatera Utara, Medan, Indonesia
  • Raja Nurhayati Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, General Hospital of Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.020

Keywords:

Skin tag, Serum leptin level, Type and number of skin tag

Abstract

BACKGROUND: Skin tag is a benign tumour of connective tissue in the skin, sessile or pedunculated, skin-like to brownish coloured and often arises in the flexure area. Etiopathogenesis of skin tag is still unclear, but one of the aetiology is associated with leptin hormone.

AIM: To determine the correlation between leptin serum level with type and number of the lesion skin tag.

METHODS: This study is an observational analytic study with a cross-sectional design involving 33 skin tag patients. Diagnosis of skin tag was based on history and clinical examination; we conducted blood sampling and measurement of serum leptin level to the patients.

RESULTS: We found the mean serum leptin level of skin tag patients were highest on the type of lesion mixed (31.54 ± 12.85 ng/ml). The mean number of skin tag lesions was 13.6 ± 5.8 lesions. There is a very high positive correlation between serum leptin level with a number of skin tag (r = 0.86) with p < 0.05 and significant correlation between serum leptin level with the type of lesions (p = 0.037).

CONCLUSION: Serum leptin level has a very high positive correlation to a number of skin tag and significant correlation between serum leptin level with the type of lesion.

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References

Chairawaty T. Profil Lemak Dalam Serum Dan Indeks Massa Tubuh Pada Pasien Skin Tag (Master's thesis), 2014.

Jusuf NK, Putra IB, Kartayana J. The correlation between body mass index with the occurrence of skin tag. Open Access Maced J Med Sci. 2017; 5(3): 271-4. https://doi.org/10.3889/oamjms.2017.061

Sudy E, Urbina F, Maliqueo M, Sir T. Screening of glucose/insulin metabolic alterations in men with mutiple skin tag on the neck. JDDG. 2008; 6:852-5. PMid:18397315

El Safoury OS, Ibrahim M. A clinical evaluation of skin tag in relation to obesity, type 2 diabetes mellitus, age and sex. Indian J Dermatol. 2011; 56(4):393-7. https://doi.org/10.4103/0019-5154.84765 PMid:21965846 PMCid:PMC3179001

Kartayana J, Putra IB, Jusuf NK. Identification of human papilloma virus (HPV) types 6 and 11 in skin tags using polymerase chain reaction (PCR). Stem Cell Oncology. 2017:11-4.

Barbato MT, Criado PR, Silva AK, Averbeck E, Guerined MB, Sa NB. Association of acanthosis nigricans and skin tag with insulin resistance. An Bras Dermatol. 2012; 87(1):97-104. https://doi.org/10.1590/S0365-05962012000100012 PMid:22481657

Yunita C, Siregar R, Purnama SW. Hubungan resistensi insulin dengan jumlah lesi skin tag di RSUP H. Adam Malik Medan [tesis]. Medan: Universitas Sumatera Utara. 2016. PMCid:PMC4839548

Gorpelioglu C, Erdal E, Ardicoglu Y, Adam B, Sarifakioglu E. Serum leptin, atherogenic lipids and glucose levels in patients with skin tag. Indian J Dermatol. 2009; 54:20-2. https://doi.org/10.4103/0019-5154.48980 PMid:20049263 PMCid:PMC2800864

Sinaga RM, Putra IB, Jusuf NK. Profil kadar glukosa darah pada pasien skin tag [tesis]. Medan: Universitas Sumatera Utara, 2014.

Kartayana J, Putra IB, Jusuf NK. Hubungan antara kadar hemoglobin A1c (HbA1c) dengan kejadian skin tag [tesis]. Medan: Universitas Sumatera Utara, 2016.

Manal B, Olfat S. The tissue expression of insulin-like growth factor (IGF- I) in acrochordons. J Egypt Wom Dermatol Soc. 2007; 4:57-62.

Idris S, Sunitha S. Assessment of BMI, serum leptin levels and lipid profile in patients with skin tag. J Clin and Diagnostic Research. 2014; 9:1-3.

El Safoury OE, Fawzy MM, Abdel-hay RM, Hassan AS, EL Maadawi ZM, Rashed LA. Increased tissue leptin hormone level and mast cell count in skin tag: a possible role of adipoimmune in the growth of benign skin growths. Indian J Dermatol. 2010; 76:538-42.

Erkek E, Kisa U, Bagci Y, Sezikli H. Leptin resistance and genetic Predisposition as potential mechanism in the development of skin tag. Hong Kong J Dermatol venerol. 2011; 19:108-14.

Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004; 145(5):2273-82. https://doi.org/10.1210/en.2003-1336 PMid:14726444

Gautama PA, Wardhana M, Swastika M. Kadar leptin serum dan indeks massa tubuh berkorelasi positif dengan jumlah lesi skin tag [tesis]. Denpasar: Universitas Udayana, 2014. PMid:25374188

Published

2019-01-08

How to Cite

1.
Putra IB, Siregar R, Jusuf NK, Ginting O, Nurhayati R. Correlation between Serum Leptin Level with Type and Number of Lesion Skin Tag. Open Access Maced J Med Sci [Internet]. 2019 Jan. 8 [cited 2021 Jun. 25];7(1):53-5. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.020

Issue

Section

B - Clinical Sciences

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