Androgen Receptor Expression in Epithelial and Stromal Cells of Prostatic Carcinoma and Benign Prostatic Hyperplasia

Vanja Filipovski; Katerina Kubelka-Sabit; Dzengis Jasar; Vesna Janevska

doi:10.3889/oamjms.2017.151

Authors

Vanja Filipovski Acibadem Sistina, Department of Histopathology and Cytology, Skopje
Katerina Kubelka-Sabit Acibadem Sistina, Department of Histopathology and Cytology, Skopje
Dzengis Jasar Acibadem Sistina, Department of Histopathology and Cytology, Skopje
Vesna Janevska Institute of Pathology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2017.151

Keywords:

prostatic carcinoma, androgen receptor, epithelium, stroma, tumour grade

Abstract

BACKGROUND: Prostatic carcinoma (PCa) derives from prostatic epithelial cells. However stromal microenvironment, associated with malignant epithelium, also plays a role in prostatic carcinogenesis. Alterations in prostatic stromal cells contribute to the loss of growth control in epithelial cells that lead to progression of PCa.

AIM: To analyse the differences between Androgen Receptor (AR) expression in both epithelial and stromal cells in PCa and the surrounding benign prostatic hyperplasia (BPH) and to compare the results with tumour grade.

MATERIAL AND METHODS: Samples from 70 cases of radical prostatectomy specimens were used. The expression and intensity of the signal for AR was analysed in the epithelial and stromal cells of PCa and BPH, and the data was quantified using histological score (H-score).

RESULTS: AR showed significantly lower expression in both epithelial and stromal cells of PCa compared to BPH. In PCa a significant positive correlation of AR expression was found between stromal and epithelial cells of PCa. AR expression showed a correlation between the stromal cells of PCa and tumour grade.

CONCLUSION: AR expression is reduced in epithelial and stromal cells of PCa. Expression of AR in stromal cells of PCa significantly correlates with tumour grade.

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