In Vitro Action of Meconium on Bronochomotor Tonus of Newborns with Meconium Aspiration Syndrome

Arsim Haliti; Lirim Mustafa; Sadi Bexheti; Drita Islami; Adnan Bozalija; Ragip Shabani; Hilmi Islami

doi:10.3889/oamjms.2018.244

Authors

Arsim Haliti Department of Pharmacy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Lirim Mustafa Institution KFLM, Agim Ramadani, Prishtina, Kosovo
Sadi Bexheti Department of Anatomy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Drita Islami Department of Pharmacology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Adnan Bozalija Department of Pharmacy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Ragip Shabani Department of Pathology, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosovo
Hilmi Islami Department of Pharmacology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo

DOI:

https://doi.org/10.3889/oamjms.2018.244

Keywords:

Acetylcholine, histamine, trachea, meconium

Abstract

AIM: Here we studied the role of meconium in the respiratory system on live and exited newborns (weight 250-3000 g). Throughout this study is followed the response of tracheal rings in acetylcholine and histamine in different molar concentrations (10^-1, 10^-2, 10^-3, 10^-4 mol/dm³).

METHODS: To study the smooth tracheal musculature we used 23 tracheal preparations obtained from the newborns exited from meconium aspiration.

RESULTS: Based on the functional analysis of the tracheal specimen we have concluded that theÂ meconium aspiration did not change the smooth musculature responseÂ on acetylcholine and histamine whenÂ compared to control group, exitedÂ from lung inflammatory processes (e.g., pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage), where tracheal smooth musculature response is significant (PÂ for other causes is not significant (P > 0.01).

CONCLUSION: The conclusionsÂ suggest that meconium didÂ not potentiate the constrictor action of acetylcholine and histamine in the tracheobronchial system and did not cause modulation of bronchomotor tonus in case of his aspiration. Meconium causes mild relaxation of smooth tracheal musculature with a mechanism which is not mediated by cyclooxygenase products, from tracheal epithelium or proteins. Also, direct activity in the smooth musculature of several tested acids seems to have no significant impact in increasing the tonus of respiratory airway of smooth tracheal musculature.

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