A Comparison of Metoclopramide and Ondansetron Efficacy for the Prevention of Nausea and Vomiting In Patients Suffered From Renal Colic


  • Abolfazl Jokar Department of Emergency Medicine, Arak University of Medical Sciences, Arak
  • Peyman Khademhosseini Department of Emergency Medicine, Karaj University of Medical Sciences, Alborz
  • Koroosh Ahmadi Department of Emergency Medicine, Karaj University of Medical Sciences, Alborz
  • Alireza Sistani Department of Emergency Medicine, Arak University of Medical Sciences, Arak
  • Mohammad Amiri Department of Emergency Medicine, Azad Tehran University of Medical Sciences, Azad, Tehran
  • Arash Gorji Sinaki Department of Emergency Medicine, Bam University of Medical Sciences, Bam




Metoclopramide, Ondansetron, Nausea and vomiting, Renal colic


BACKGROUND: Renal stones are the third common disease of the urinary system after infections and diseases of the prostate. One of the most common manifestations of this disease after acute pain is nausea and vomiting.

AIM: To compare the efficacy of metoclopramide and ondansetron in improving nausea and vomiting in patients referred to the emergency department with a chief complaint of nausea and vomiting.

METHODS: This randomised double-blind clinical trial was conducted on patients referred to the emergency department of Vali-e Asr Hospital. Mg5 intravenous morphine and ketorolac ampoule were injected to control renal colic. Then, patients were randomly divided into two groups. Group 1 consisted of 90 subjects receiving 10 mg intravenous metoclopramide and group 2 including 90 subjects receiving 4 mg intravenous ondansetron. Vital signs were also measured and recorded.

RESULTS: The mean and standard deviation of nausea in 0, 15, 30, 45, 60 and 120 minutes showed no significant difference between the two groups. Mean and standard deviation of vomiting at 0 minutes showed no significant difference between the two groups, but the remaining minutes, 15, 30, 45, 60 and 120, exhibited significant difference as a comparison of two groups, indicating that vomiting in the metoclopramide group was higher than ondansetron group.

CONCLUSION: Our findings indicated that ondansetron was more effective than metoclopramide in preventing and improving vomiting in patients referred to emergency renal colic, where can be used with more efficacy and more acceptable side effects to improve nausea and vomiting.


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How to Cite

Jokar A, Khademhosseini P, Ahmadi K, Sistani A, Amiri M, Sinaki AG. A Comparison of Metoclopramide and Ondansetron Efficacy for the Prevention of Nausea and Vomiting In Patients Suffered From Renal Colic. Open Access Maced J Med Sci [Internet]. 2018 Oct. 18 [cited 2021 Oct. 24];6(10):1833-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.302



B - Clinical Sciences