A Comparison of Metoclopramide and Ondansetron Efficacy for the Prevention of Nausea and Vomiting In Patients Suffered From Renal Colic
DOI:
https://doi.org/10.3889/oamjms.2018.302Keywords:
Metoclopramide, Ondansetron, Nausea and vomiting, Renal colicAbstract
BACKGROUND: Renal stones are the third common disease of the urinary system after infections and diseases of the prostate. One of the most common manifestations of this disease after acute pain is nausea and vomiting.
AIM: To compare the efficacy of metoclopramide and ondansetron in improving nausea and vomiting in patients referred to the emergency department with a chief complaint of nausea and vomiting.
METHODS: This randomised double-blind clinical trial was conducted on patients referred to the emergency department of Vali-e Asr Hospital. Mg5 intravenous morphine and ketorolac ampoule were injected to control renal colic. Then, patients were randomly divided into two groups. Group 1 consisted of 90 subjects receiving 10 mg intravenous metoclopramide and group 2 including 90 subjects receiving 4 mg intravenous ondansetron. Vital signs were also measured and recorded.
RESULTS: The mean and standard deviation of nausea in 0, 15, 30, 45, 60 and 120 minutes showed no significant difference between the two groups. Mean and standard deviation of vomiting at 0 minutes showed no significant difference between the two groups, but the remaining minutes, 15, 30, 45, 60 and 120, exhibited significant difference as a comparison of two groups, indicating that vomiting in the metoclopramide group was higher than ondansetron group.
CONCLUSION: Our findings indicated that ondansetron was more effective than metoclopramide in preventing and improving vomiting in patients referred to emergency renal colic, where can be used with more efficacy and more acceptable side effects to improve nausea and vomiting.
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Mee MJ, Egerton-Warburton D, Meek R. Treatment and assessment of emergency department nausea and vomiting in Australasia: a survey of anti-emetic management. Emerg Med Australas. 2011; 23:162-168. https://doi.org/10.1111/j.1742-6723.2011.01386.x PMid:21489163
Ahmed HU, Khan AA, Bafaloukas N, Shergill IS, Buchholz NP. Diagnosis and management of renal (ureteric) colic. Br J Hosp Med (Lond). 2006; 67(9):465-9. https://doi.org/10.12968/hmed.2006.67.9.21998 PMid:17017608
Serinken M, Eken C, Turkcuer I, Elicabuk H, Uyanik E, Schultz CH. Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial. Emerg Med J. 2012; 29(11):902-5. https://doi.org/10.1136/emermed-2011-200165 PMid:22186009
Jalili M, Fathi M, Moradi-Lakeh M, Zehtabchi S. Sublingual buprenorphine in acute pain management: a double-blind, randomised clinical trial. Annals of emergency medicine. 2012; 59(4):276-80. https://doi.org/10.1016/j.annemergmed.2011.10.021 PMid:22115823
Song SW, Kim K, Rhee JE, Lee JH, Seo GJ, Park HM. Butylscopolammonium bromide does not provide additional analgesia when combined with morphine and ketorolac for acute renal colic. Emerg Med Australas. 2012; 24(2):144-50. https://doi.org/10.1111/j.1742-6723.2011.01502.x PMid:22487663
Egerton-Warburton D1, Meek R2, Mee MJ3, Braitberg G1. Antiemetic use for nausea and vomiting in adult emergency department patients: a randomised controlled trial comparing ondansetron, metoclopramide, and placebo. Ann Emerg Med. 2014; 64(5):526-532. https://doi.org/10.1016/j.annemergmed.2014.03.017 PMid:24818542
Carlisle J, Stevenson CA. Drugs for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev. 2006; (3): CD004125. https://doi.org/10.1002/14651858.CD004125.pub2
Billio A, Morello E, Clarke MJ. Serotonin receptor antagonists for highly emetogenic chemotherapy in adults. Cochrane Database Syst Rev. 2010; (1):CD006272. https://doi.org/10.1002/14651858.CD006272.pub2
Hendey GW, Donner NF, Fuller K. Clinically significant changes in nausea as measured on a visual analogue scale. Ann Emerg Med. 2005; 45:77-81. https://doi.org/10.1016/j.annemergmed.2004.07.446 PMid:15635314
Lussos SA1, Bader AM, Thornhill ML, Datta S. The antiemetic efficacy and safety of prophylactic metoclopramide for elective cesarean delivery during spinal anaesthesia. Reg Anesth. 1992; 17(3):126-30. PMid:1606094
Kestin IG1.Spinal anaesthesia in obstetrics. Br J Anaesth. 1991; 66(5):596-607. https://doi.org/10.1093/bja/66.5.596
Nesioonpour SH, Pipelzadeh MH, Mohtadi AR, Rezai S, Feghhi M, Malekshoar M. A Comparative Study of Dexamethasone, Granisetron and Metoclopramide for Prevention of Nausea and Vomiting after Cataract Surgery. Bina J Ophthalmol. 2009; 14(4):413-19.
Gautam B, Shrestha BR, Lama P, Rai S. Antiemetic prophylaxis against postoperative nausea and vomiting with the ondansetron-dexamethasone combination compared to ondansetron or dexamethasone alone for patients undergoing laparoscopic cholecystectomy. Kathmandu Univ Med J (KUMJ). 2008; 6(23):319-28.
Shokeir AA1. Renal colic: pathophysiology, diagnosis and treatment. Eur Urol. 2001; 39(3):241-9. https://doi.org/10.1159/000052446 PMid:11275712
Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual analog scale for pain (vas pain), numeric rating scale for pain (not pain), mcgill pain questionnaire (mpq), shortâ€form mcgill pain questionnaire (sfâ€mpq), chronic pain grade scale (cpgs), short formâ€36 bodily pain scale (sfâ€36 bps), and measure of intermittent and constant osteoarthritis pain (icoap). Arthritis care & research. 2011; 63(S11):S240-52. https://doi.org/10.1002/acr.20543 PMid:22588748
Grasso AA, Cozzi G. Etiology, diagnosis and treatment of renal colic during pregnancy. Urologia. 2014; 81(1):12-5. https://doi.org/10.5301/urologia.5000048 PMid:24557816
Gul Z, Monga M. Medical and dietary therapy for kidney stone prevention. Korean J Urol. 2014; 55(12):775-9. https://doi.org/10.4111/kju.2014.55.12.775 PMid:25512810 PMCid:PMC4265710
Zahedi H, Rouzbeh Kargar L. Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section. JBUMS. 2004; 6(3):32-36.
Braude D, Soliz T, Crandall C, et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006; 24:177-182. https://doi.org/10.1016/j.ajem.2005.08.017 PMid:16490647
Mortazavi Y. Effect of metoclopramide and ondansetrone plus dexamethason on postoperative nausea and vomiting in cholecystectomy laparoscopic surgery. Journal of Gorgan University of Medical Sciences. 2014; 16(1):9-13.
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