The Difference in Effect of Arabica Coffee Gayo Beans and Leaf (Coffea Arabica Gayo) Extract on Decreasing Blood Sugar Levels in Healthy Mice

Sake  Juli  Martina; Pradeepa A. P.  Govindan; Arlinda Sari Wahyuni

doi:10.3889/oamjms.2019.423

Authors

Sake Juli Martina Department of Pharmacology and Therapeutics Faculty of Medicine, Jl. Dr Mansur No.5 Kampus USU, Medan, Indonesia; University Sumatera Utara Hospital, Jalan dr. T. Mansur No.66 Kampus USU, Medan, Indonesia
Pradeepa A. P. Govindan Department of Pharmacology and Therapeutics Faculty of Medicine, Jl. Dr Mansur No.5 Kampus USU, Medan, Indonesia
Arlinda Sari Wahyuni Department of Public Health, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr Mansur No.5 Kampus USU Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.423

Keywords:

Acarbose, Green Coffee Bean Extract

Abstract

BACKGROUND: High incidence rate of diabetes mellitus (DM) and increased incidence of complications from DM as well as the use of less effective antidiabetic drugs and high financing to treat demands alternative therapy.

AIM: This study was conducted to determine the difference in the effect of Arabica coffee gayo bean and leaf extract on blood sugar levels in healthy mice before and after the intervention of extract and fasting and postprandial blood glucose level after consumption of glucose.

METHODS: This research is an experimental research study. The study used experimental animals which were divided into 8 groups which are the control group (Aquadest), group given Acarbose, the group given the Arabica coffee gayo bean extract with dosage of 50 mg, 100 mg and 200 mg in healthy mice, the group given the Arabica coffee gayo leaf extract with dosage of 30 mg, 60 mg and 120 mg in healthy mice.

RESULTS: The results of the study obtained are before and after the intervention of extract showed the difference of p= 0.523 and after consumption of glucose the fasting and postprandial result showed the difference of p = 0.005.

CONCLUSION: The use of Arabica coffee gayo bean and leaf extract showed a high decrease in blood glucose levels (BGL) compared to the control group.