The Antifungal Activity of n-Hexane Extract of Eleutherine palmifolia (L). Merr Bulbs Against Candida albicans and Trichophyton mentagrophytes

Authors

  • Masfria Masfria Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Mitra S. A. Tampubolon Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.502

Keywords:

Antifungal, Eleutherine palmifolia bulbs, Candida albicans, Trichophytonmentagrophytes

Abstract

AIM: This research aimed to determine the characteristics of dried bulbs of Eleutherine palmifolia, the group of active chemical compounds contained in n-hexane extract of Eleutherine palmifolia bulbs and the antifungal activity of n-hexane extract of Eleutherine palmifolia bulbs against Candida albicans and Trichophyton mentagrophytes.

METHODS: The Eleutherine palmifolia bulbs were extracted by percolation method using n-hexane solvent. The extract was tested for its antifungal activity against Candida albicans and Trichophyton mentagrophytes by diffusion method using paper discs.

RESULTS: The characterisation of dried Eleutherine palmifolia bulbs were obtained water content 9.38%, water-soluble extract content 12.15%, ethanol-soluble extract content 14.48%, total ash content 0.91%, and acid insoluble ash content 0.70%. Determination of Phytochemical content showed alkaloid, flavonoid, tannin, saponin, glycoside, and steroid/triterpenoid compounds. The antifungal activity of Eleutherine palmifolia bulbs n-hexane extract (EPBHE) by concentration 200 mg/ml demonstrated the inhibition diameter of 19.48 and 42.20 mm for Candida albicans and Trichophyton metagrophytes, respectively.

CONCLUSION: The antifungal test indicates that n-hexane extract of Eleutherine palmifolia bulbs provides inhibitory power to Candida albicans and Trichophyton mentagrophytes.

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Published

2019-11-14

How to Cite

1.
Masfria M, Tampubolon MSA. The Antifungal Activity of n-Hexane Extract of Eleutherine palmifolia (L). Merr Bulbs Against Candida albicans and Trichophyton mentagrophytes. Open Access Maced J Med Sci [Internet]. 2019 Nov. 14 [cited 2024 Mar. 5];7(22):3777-80. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.502

Issue

Section

Herbal Medicine in Pharmaceutical and Clinical Sciences