Oxidative Stress and Anti-Oxidant Markers in Premature Infants with Respiratory Distress Syndrome
DOI:
https://doi.org/10.3889/oamjms.2019.534Keywords:
Oxidative stress, Newborn, Respiratory distress disorder, Antioxidant enzymesAbstract
BACKGROUND: Neonatal respiratory distress syndrome (RDS) caused by decreased surfactant and structural lung immaturity. The imbalance between oxidative status and antioxidant defence system was suggested to be an important trigger for lung affection with RDS.
AIM: The goal of the current research was to elucidate the significance of the oxidant/ antioxidant status in the pathogenesis of RDS in preterm infants.
PATIENTS AND METHODS: This controlled study included 31 preterm neonates with RDS and 36 healthy preterm neonates. Quantification level of oxidative stress biomarkers; malondialdehyde (MDA) & hydrogen peroxide (H2O2) along with antioxidant enzymes activity; catalase (CAT) & superoxide dismutase (SOD) in plasma of healthy premature neonates compared with those with RDS.
RESULTS: status of oxidative stress markers (MDA & H2O2) showed a significant increase with decreased levels of antioxidant enzymes activity (CAT & SOD) in neonates with RDS when compared to healthy prematures.
CONCLUSION: The results obtained in this study indicate that the increased oxidative stress accompanied by reduced antioxidant defences may play a significant role in the pathogenesis of respiratory distress in preterm newborns.
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Ozsurekci Y, Aykac K. Oxidative Stress Related Diseases in Newborns. Oxid Med Cell Longev. 2016; 2016:2768365. https://doi.org/10.1155/2016/2768365 PMid:27403229 PMCid:PMC4926016
Negi R, Pande D, Karki K, Kumar A, Khanna RS, Khanna HD. A novel approach to study oxidative stress in neonatal respiratory distress syndrome. BBA Clin. 2015; 8:65-69. https://doi.org/10.1016/j.bbacli.2014.12.001 PMid:26676080 PMCid:PMC4661505
Gitto E, Pellegrino S, Gitto P, Barberi I, Reiter RJ. Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. J Pineal Res. 2009; 46(2):128-39. https://doi.org/10.1111/j.1600-079X.2008.00649.x PMid:19054296
Marseglia L, D'Angelo G, Manti S, et al. Oxidative stress-mediated gained during the fetal and perinatal periods. Oxid Med Cell Longev. 2014; 2014:358-375. https://doi.org/10.1155/2014/358375 PMid:25202436 PMCid:PMC4151547
Mutinati M, Pantaleo M, Roncetti M, Piccinno M, Rizzo A, Sciorsci RL. Oxidative stress in neonatology: a review, Reprod Domest Anim. 2014; 49(1):7-16. https://doi.org/10.1111/rda.12230 PMid:24112309
Perron S, Tataranno ML, Negro S, et al. Early identification of the risk for free radical-related diseases in preterm newborns. Early Human Development. 2010; 86(4):241-244. https://doi.org/10.1016/j.earlhumdev.2010.03.008 PMid:20466493
Jain D, Atochina-Vasserman EN, Tomer, Y, Kadire H, Beers MF. Surfactant protein D protects against acute hyperoxic lung injury. Am J Respir Crit Care Med. 2008; 178:805-813. https://doi.org/10.1164/rccm.200804-582OC PMid:18635887 PMCid:PMC2566792
Ighodaro OM, Akinloye OA. First line defence antioxidiants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alex J. Med. 2018; 54:287-293. https://doi.org/10.1016/j.ajme.2017.09.001
Poggi C, Dani C. Antioxidant Strategies and Respiratory Disease of the preterm Newborn: An Update, Oxid Med Cell Longev. 2014; 2014:1-10. https://doi.org/10.1155/2014/721043 PMid:24803984 PMCid:PMC3996983
Matalon S, Holm BA, Baker RR, whitefield MK, Freeman BA. Characterization of antioxidant activities of pulmonary surfactant mixtures. Biochemica et Biophysica Acta-General subjects. 1990; 1035(2):121-127. https://doi.org/10.1016/0304-4165(90)90105-6
Dani C, Buonocore, G, Longini M, et al., Superoxide dismutase and catalase activity in naturally derived commercial surfactants. Pediatr pulmonol. 2009; 44:1125-1131. https://doi.org/10.1002/ppul.21116 PMid:19830697
Siddique Y, Afzal M. Estimation of lipid peroxidation included by hydrogen peroxide in cultured human lymphocytes. Dose Response. 2012; 10:1-10. https://doi.org/10.2203/dose-response.10-002.Siddique PMid:22423225 PMCid:PMC3299524
Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 1978; 90:37-43. https://doi.org/10.1016/0009-8981(78)90081-5
Aebi H. Catalase in vitro. Meth Enzymol. 1984;105:121-6. https://doi.org/10.1016/S0076-6879(84)05016-3
Nishikimi M, Rao NA, Yagi K. The occurrence of superoxideanion in the reaction of reduced phenazine methosulfate andmolecular oxygen. Biochem Biophys Res Commun. 1972;46:849-54. https://doi.org/10.1016/S0006-291X(72)80218-3
Joshi SR, Mehendale SS, Dangat KD, Kilari AS, Yadav HR, Taralekar VS. High maternal plasma antioxidant concentrations associated with preterm delivery. Ann Nutr Metab. 2008; 53:276-82. https://doi.org/10.1159/000189789 PMid:19141991
Finer N, Leone T. Oxygen saturation monitoring for the preterm infant: the evidence basis for current practice. Pediatr Res. 2009; 65(4):375-380. https://doi.org/10.1203/PDR.0b013e318199386a PMid:19127213
Yaacobi N, Ohel G, Hochman A. Reactive oxygen species in the process of labor. Arch Gynecol Obstet. 1999; 263:23-24. https://doi.org/10.1007/s004040050255 PMid:10728623
Mutlu B, Aksoy N, Cakir H, Celik H, Erel O. The effects of the mode of delivery on oxidative-antioxidative balance. J Matern Fetal Neonatal Med. 2011; 24:1367-1370. https://doi.org/10.3109/14767058.2010.548883 PMid:21247235
Gerten K.A, Coonrod DV, Bay RC, Chambliss LR. Cesarean delivery and respiratory distress syndrome: does labor make a difference?. Am J Obstet Gynecol. 2005; 193 (3):1061-1064. https://doi.org/10.1016/j.ajog.2005.05.038 PMid:16157112
Lauire S, Mataz Z, Boaz M, et al. Different degrees of fetal oxidative stress in elective and emergent caesarean section. Neonatology. 2007; 92:111-115. https://doi.org/10.1159/000100965 PMid:17377411
Kaltofen T, Haase M, Thome UH, Laube M. Male sex is associated with a reduced alveolar epithelial sodium transport. PLoS ONE. 2015; 10(8):e0136178. https://doi.org/10.1371/journal.pone.0136178 PMid:26291531 PMCid:PMC4546327
Stein P, School TO, Schuter MD, et al. Oxidative stress early in pregnancy and pregnancy outcome. Free Res. 2008; 42:841-848. https://doi.org/10.1080/10715760802510069 PMid:18985484
Marttila R, Kaprio J, Hallman M. Respiratory distress syndrome in twin infants compared with singletons. Am J Obstet Gynecol. 2004; 191 (1):271-276. https://doi.org/10.1016/j.ajog.2003.11.020 PMid:15295378
Sardesai S, Biniwale M, Wertheimer F, Rangasamy A. Evolution of surfactant therapy for respiratory distress syndrome: past, present, and future. Pediatr Res. 2016; 81(1-2):240-248. https://doi.org/10.1038/pr.2016.203 PMid:27706130
Carty JL, Bevan R, Waller H. The effects of vitamin C supplementation on protein in healthy volunteers. Biochem. Res. Com. 2000; 273:729-735. https://doi.org/10.1006/bbrc.2000.3014 PMid:10873672
Stevens TP, Harrington EW, Blennow M, Soll RF. Early surfactant administration with breif ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev. 2007; 17(4):CD003063. https://doi.org/10.1002/14651858.CD003063.pub3
Jerneck KT, Herbst A. Low 5-minute Apgar score: a population-based register study of 1 million term births. Obstet Gynecol. 2001; 98(1):65-70. https://doi.org/10.1016/S0029-7844(01)01370-9
Zahran A, Mohamed M, Amer M. Measurement of oxidant-antioxidant markers in premature newborn with respiratory distress syndrome. Int. J. Adv. Res. 2017; 5(2):1287-1293. https://doi.org/10.21474/IJAR01/3281
Dizdar E, Uras, N, Oguz S, Erdeve O, Sari F, Aydemir C, Dilmen U. Total antioxidant capacity and total oxidant status after surfactant treatment in preterm infants with respiratory distress syndrome. Ann Clin Biochem. 2011; 48:462-467. https://doi.org/10.1258/acb.2011.010285 PMid:21775575
Krediet TG, Cirkel GA, Vreman HJ, Wong RJ, Stevenson DK, Groenendaal F, Egberts J, VanBel F. End-tidal carbon monoxide measurements in infants with respiratory distress syndrome. Acta Paediatr. 2006; 95:1075-1082. https://doi.org/10.1080/08035250500537017 PMid:16938753
Lang JD, McArdle PJ, O'Reilly PJ, Matalon S. Oxidant-antioxidant balance in acute lung injury. Chest. 2002; 122:314S-320S. https://doi.org/10.1378/chest.122.6_suppl.314S PMid:12475808
Chang LY, Subramaniam M, Yoder BA, et al. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2003; 167:57-64. https://doi.org/10.1164/rccm.200203-232OC PMid:12502477
Dani C, Corsini L, Longini M, Burchielli S, Dichiara G, Cantile, Buonocore G. Natural sufractant combined with superoxide dismutase and catalase decreases oxidative lung injury in the preterm lamb. Pediatr Pulmonol. 2014; 49:898-904. https://doi.org/10.1002/ppul.22955 PMid:24339445
Contreras M, HariharanN, Lewandoski JR, Ciesielski W, Koscik R, Zimmerman JJ. Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia. Crit Care Med. 1996; 24:29-37. https://doi.org/10.1097/00003246-199601000-00008 PMid:8565534
Bahbah M, Deeb M, Ragab S, El-Shafie M. Study of oxidative stress in common neonatal disorders and evaluation of antioxidant strategies. Menoufia Medical Journal. 2015; 28:348-354. https://doi.org/10.4103/1110-2098.163883
Tridade CEP. Microelements and vitamins in the nutrition of very low birth weight preterm infants: a Brazilian perspective. NeoReviews. 2007; 8:e3-e13. https://doi.org/10.1542/neo.8-1-e3
Vento M, Aguar M, Escobar J, Arduini A, Escrig R, Brugada M, et al. Antenatal steroids and antioxidant enzyme activity in preterm infants: influence of gender and timing. Antioxid Redox Signal. 2009; 11:2945-2955. https://doi.org/10.1089/ars.2009.2671 PMid:19645572
Schultz C, Tautz J, Reiss I, et al. Prolonged mechanical ventilation induces pulmonary inflammation in preterm infants. Biol Neonate. 2003; 84:64-66. https://doi.org/10.1159/000071446 PMid:12890939
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Copyright (c) 2019 Enas R. Abdel Hamid, Walaa H. Ali, Ashraf Azmy, Hanaa H. Ahmed, Lobna S. Sherif, Maysa T. Saleh (Author)
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