Features of the Course of Various types of Stroke in Patients Exposed to Low-dose Radiation

Authors

  • A. A. Chinybayeva Corporate fund “University Medical Center”, Astana, Kazakhstan
  • L. K. Karazhanova Department of Cardiology and Interventional Arrhythmology, Non-Commercial Joint-Stock Company “Semey Medical University”, Semey, Kazakhstan
  • J. A. Mansurova Department of Cardiology and Interventional Arrhythmology, Non-Commercial Joint-Stock Company “Semey Medical University”, Semey, Kazakhstan https://orcid.org/0000-0003-2439-2056
  • A. S. Zhunuspekova Department of Cardiology and Interventional Arrhythmology, Non-Commercial Joint-Stock Company “Semey Medical University”, Semey, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2023.11106

Keywords:

Stroke, Hemostasis, Semipalatinsk nuclear testing site, Radiation

Abstract

BACKGROUND: There is limited number of studies about peculiarities of cardiovascular diseases in population of different region by the zone of radiation exposure risk.

AIM: The aim of the study was to study the effect of radiation factor on the pathogenesis of stroke.

MATERIALS AND METHODS: To study the in influence of radiation factor on pathogenesis of stroke, 358 stroke patients were distributed based on the place of their residence into corresponding zones of radiation risk: 53 patients lived in zone of extremely high radiation level (488–100 cSV, zone I): 75 - from the zone of maximal radiation exposure (35–100 cSV, zone II), 158 - from zone with high radiation exposure (35–7 cSV, zone III), and 72 patients were the residents of minimal radiation risk (1–7 cSV, zone IV).

RESULTS: The study of coagulation hemostasis had revealed the significant increase of fibrinogen level in patients from zone I: 4.7 ± 0.14% versus 3.2 ± 0.11%, in patients living in minimal radiation risk zone (p < 0.01). The patients from extremely high radiation risk had significant decrease in fibrinolysis time in comparison to patients from zone IV (p < 0.05). The primary APS was diagnosed in 24 (6.7%) patients in total group of stroke patients (11 males and 13 females), from which 21 patients with ischemic stroke and 3 with hemorrhagic stroke. Leiden Va defect was found significantly more often in patients lived in high radiation risk zone (9.4%), in 13.5% stroke patients from zone II, in 13.2% patients lived in zone I, in comparison to 6.9% patients lived in zone IV. The patients from zone I had significantly higher level of plasma homocysteine in comparison to patients from other zones, (p < 0.01). Furthermore, the significantly higher levels of plasma homocysteine were found in the group with maximal and high radiation exposure, in comparison to the group of patients from minimal risk zone (p < 0.05).

CONCLUSIONS: We can see the presence of indirect evidences of modifying influence of radiation factor on pathogenic mechanisms of stroke.

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References

Shimizu Y, Kodama K, Nishi N, Kasagi F, Suyama A, Soda M, et al. Radiation exposure and circulatory disease risk: Hiroshima and nagasaki atomic bomb survivor data, 1950-2003. BMJ. 2010;340:b5349. https://doi.org/10.1136/bmj.b5349 PMid:20075151 DOI: https://doi.org/10.1136/bmj.b5349

Preston DL, Pierce DA, Shimizu Y, Cullings HM, Fujita S, Funamoto S, et al. Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates. Radiat Res. 2004;162(4):377-89. https://doi.org/10.1667/rr3232 PMid:15447045 DOI: https://doi.org/10.1667/RR3232

Little MP, Tawn EJ, Tzoulaki I, Paris F, Tapio S, Elliott P, et al. Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms. Radiat Environ Biophys. 2010;49(2):139-53. https://doi.org/10.1007/s00411-009-0250-z PMid:19862545 DOI: https://doi.org/10.1007/s00411-009-0250-z

Shimizu Y, Pierce DA, Preston DL, Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, Part II. Noncancer mortality: 1950-1990. Radiat Res. 1999;152(4):374-89. PMid:10477914 DOI: https://doi.org/10.2307/3580222

Cullings HM. Impact on the Japanese atomic bomb survivors of radiation received from the bombs. Health Phys. 2014;106(2):281- 293. https://doi.org/10.1097/HP.0000000000000009 DOI: https://doi.org/10.1097/HP.0000000000000009

Wang Y, Boerma M, Zhou D. Ionizing radiation-induced endothelial cell senescence and cardiovascular diseases. Radiat Res. 2016;186(2):153-61. https://doi.org/10.1667/RR14445.1 PMid:27387862 DOI: https://doi.org/10.1667/RR14445.1

Donato AJ, Morgan RG, Walker AE, Lesniewski LA. Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol. 2015;89(Pt B):122-35. https://doi.org/10.1016/j.yjmcc.2015.01.021 PMid:25655936 DOI: https://doi.org/10.1016/j.yjmcc.2015.01.021

Sermsathanasawadi N, Ishii H, Igarashi K, Miura M, Yoshida M, Inoue Y, et al. Enhanced adhesion of early endothelial progenitor cells to radiation-induced senescence-like vascular endothelial cells in vitro. J Radiat Res. 2009;50(4):469-75. https://doi.org/10.1269/jrr.09036 PMid:19628926 DOI: https://doi.org/10.1269/jrr.09036

Lowe D, Raj K. Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression. Aging Cell. 2014;13(5):900-10. https://doi.org/10.1111/acel.12253 PMid:25059316 DOI: https://doi.org/10.1111/acel.12253

Geider H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP. et al. Pharmacological targeting of the thrombomodulin-activated Protein C pathway mitigates radiation toxicity. Nat Med. 2012;18(7):1123-9. https://doi.org/10.1038/nm.2813 PMid:22729286 DOI: https://doi.org/10.1038/nm.2813

Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res. 2012;35(11):1039-47. https://doi.org/10.1038/hr.2012.138 PMid:22972557 DOI: https://doi.org/10.1038/hr.2012.138

Borghini A, Gianicolo EA, Picano E, Andreassi MG. Ionizing radiation and atherosclerosis: Current knowledge and future challenges. Atheroslerosis. 2013;230(1):40-7. https://doi.org/10.1016/j.atherosclerosis.2013.06.010 PMid:23958250 DOI: https://doi.org/10.1016/j.atherosclerosis.2013.06.010

Sasaki H, Wong FL, Yamada M, Kodama K. The effects of aging and radiation exposure on blood pressure levels of atomic bomb survivors. J Clin Epidemiol. 2002;55(10):974-81. https://doi.org/10.1016/s0895-4356(02)00439-0 PMid:12464373 DOI: https://doi.org/10.1016/S0895-4356(02)00439-0

Kallfass E, Kraemling HJ, Schultz-Hector S. Early inflammatory reaction of the rabbit coeliac artery wall after combined intraoperative (IORT) and external (ERT) irradiation. Radiother Oncol. 1996;39(2):167-78. https://doi.org/10.1016/0167-8140(96)01708-2 PMid:8735484 DOI: https://doi.org/10.1016/0167-8140(96)01708-2

Fajardo LF. Basic mechanisms and general morphology of radiation injury. Semin Roentgenol. 1993;28(4):297-302. https://doi.org/10.1016/s0037-198x(05)80091-4 PMid:8272878 DOI: https://doi.org/10.1016/S0037-198X(05)80091-4

Zidar N, Ferluga D. Hvala A. Popovic M. Soba E. Contribution to the pathogenesis of radiation-induced injury to large arteries. J Laryngol Otol. 1997;111(10):988-90. https://doi.org/10.1017/s0022215100139167 PMid:9425496 DOI: https://doi.org/10.1017/S0022215100139167

Ibraev SS. Complex Estimation of the Health State of People Living at the Area Adjacent to Semipalatinsk Polygon and Exposed to Low Doses of Radiation: Avtoreph of the Candidate of Medical Science. Southeastern Kazakhstan: Alma Ata; 1992. p. 33.

Ibraev NS. The Influence of Radioactive Testing at Semipalatinsk Polygon on Health of the Population of Some Regions of the Oblast: Aftoreph of the Dissertation the Candidate of Medical Science. Northeast Kazakhstan: Semipalatinsk; 1995. p. 26.

Grosche B, Zhunussova T, Apsalikov K, Kesminiene A. Studies of Health Effects from Nuclear Testing near the Semipalatinsk Nuclear Test Site, Kazakhstan. Cent Asian J Glob Health. 2015;4(1):127. https://doi.org/10.5195/cajgh.2015.127 DOI: https://doi.org/10.5195/cajgh.2015.127

Grosche B, Simon SL, Apsalikov KN, Pivina LM, Bauer S, Gusev BI, et al Mortality from cardiovascular diseases in the Semipalatinsk historical cohort, 1960-1999, and its relationship to radiation exposure. Radiat Res. 2011;176(5):660-9. https://doi.org/10.1667/rr2211.1 PMid:21787182 DOI: https://doi.org/10.1667/RR2211.1

Mikhailidis DP, Spyropoulos KA, Ganotakis ES. Fibrinogen and lipoprotein (a): Associations in a population attending a cardiovascular risk clinic and effect of treatment with ciprofibrate. Fibrinolysis. 1996;10(Suppl):17. DOI: https://doi.org/10.1016/S0268-9499(96)80632-1

Neuber C, Pufe J, Pietzsch J. Influence of irradiation on release of endothelial microparticles (EMP) in vitro. Clinical Hemorheology and Microcirculation. 2015 Jan 1;61(2):291-9.

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Published

2023-01-02

How to Cite

1.
Chinybayeva AA, Karazhanova LK, Mansurova JA, Zhunuspekova AS. Features of the Course of Various types of Stroke in Patients Exposed to Low-dose Radiation. Open Access Maced J Med Sci [Internet]. 2023 Jan. 2 [cited 2024 Mar. 29];11(B):104-8. Available from: https://oamjms.eu/index.php/mjms/article/view/11106

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Radiology and Radiotherapy

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