Preparation and Physicochemical Characterization of Solid Dispersion of Irbesartan with Poloxamer 188


  • Fifi Harmely Department of Biomedical Sciences, Faculty of Medicine, Andalas University, Padang 25163, Indonesia
  • Salman Umar Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia
  • Yufri Aldi Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia
  • Ellyza Nasrul Department of Biomedical Sciences, Faculty of Medicine, Andalas University, Padang 25163, Indonesia
  • Erizal Zaini Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia



Physicochemical properties, Solid dispersion, Irbesartan, Poloxamer 188


AIM: The aim of the present study was to prepare and characterize the solid dispersion of poorly soluble drugs irbesartan with hydrophilic polymer poloxamer 188 by solvent co-evaporation technique.

METHODS: The ratio of irbesartan to poloxamer 188 in solid dispersion system was 1:0.5; 1:1; and 1:3. Physicochemical properties characterization was analyzed by X-ray powder diffraction, Fourier-transform infrared (FT-IR) spectroscopy, differential thermal analysis, and scanning electron microscopy (SEM). The in vitro dissolution rate profile of solid dispersion was performed by Type II United States Pharmacopeia dissolution testing apparatus.

RESULTS: The results of the X-ray powder diffraction pattern showed that the degree of crystallinity of irbesartan crystalline phase reduced in a solid dispersion system. FT-IR spectra indicate that there is no chemical interaction between irbesartan and poloxamer 188 in a solid dispersion system. SEM microscopy demonstrated a homogenous phase of a solid dispersion system with distinct crystal habit. In general, in vitro dissolution rate of all solid dispersions was higher than intact irbesartan. The highest percentage of dissolved irbesartan was the solid dispersion of irbesartan-poloxamer 188 (1:0.5 w/w).

CONCLUSIONS: The study concludes that the solid dispersion can be applied to improve the dissolution rate of irbesartan.


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Oparil S, Williams D, Chrysant SG, Marbury TC, Neutel J. Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension. J Clin Hypertens (Greenwich). 2001;3(5):283-91, 318. https://doi. org/10.1111/j.1524-6175.2001.01136.x PMid:28718426

Hayer AM. Finding solutions. Chem Eng News. 2010;88(22):13-8.

Hirlekar R, Kadam V. Preformulation study of the inclusion complex irbesartan-beta-cyclodextrin. AAPS PharmSciTech. 2009;10(1):276-81. PMid:19283492

Zhang Z, Le Y, Wang J, Zhao H, Chen J. Irbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate. Particuology. 2012;10(4):462-7. https://doi. org/10.1016/j.partic.2012.01.002

Haneef J, Chadha R. Antioxidant-based eutectics of irbesartan: Viable multicomponent forms for the management of hypertension. AAPS PharmSciTech. 2018;19(3):1191-204. PMid:29247285

Kumar GA, Ram KC, Chaitanya C. Enhancement of solubility and dissolution rate of irbesartan by solid dispersion technique. Asian J Pharm Clin Res. 2011;4(2):36-40. 7. Chawla G, Bansal AK. A comparative assessment of solubility advantage from glassy and crystalline forms of a water- insoluble drug. Eur J Pharm Sci. 2007;32(1):45-57. https://doi. org/10.1016/j.ejps.2007.05.111 PMid:17618092

Nijhawan M, Babu PR, Subrahmanyam CV. Cocrystal of irbesartan with hippuric acid. Indo Am J Pharm Res. 2015;5(4):1323-9.

Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J Pharm Sci. 1971;60(9):1281-302. https:// PMid:4935981

Serajuddin AT. Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs. J Pharm Sci. 1999;88(10):1058-66. https://doi. org/10.1021/js980403l PMid:10514356

Hang Y, Myung-Kwan C, Hoo-Kyun C. Preparation and characterization of piroxicam/poloxamer solid dispersion prepared by melting method and solvent method. J Korean Pharm Sci. 2007;37:1-5.

Ghareeb MM, Abdulrasool AA, Hussein AA, Noordin MI. Kneading technique for preparation of binary solid dispersion of meloxicam with poloxamer 188. AAPS PharmSciTech. 2009;10(4):1206-15. PMid:19862626

Zaini E, Wahyuni YS, Halim A, Yuliandra Y. Preparation of eutectic mixture of ketoprofen and nicotinamide for enhanced dissolution rate. Int J Pharm Sci Rev Res. 2015;35(1):161-4.

Alatas F, Soewandhi SN, Sasongko L, Ismunadar UH, Uekusa H. Cocrystal formation between didanosine and two aromatic acids. Int J Pharm Pharm Sci. 2013;5(3):275-80.

Wagh VT, Jagtap VA, Shaikh TJ, Nandedkar SY. Formulation and evaluation of glimepiride solid dispersion tablets for their solubility enhancement. J Adv Sci Res. 2012;3(4):36-41.

Departemen Kesehatan Republik Indonesia, Farmakope Indonesia Edisi V, Direktorat Jendral Pengawasan Obat dan Makanan: Jakarta; 2014.




How to Cite

Harmely F, Umar S, Aldi Y, Nasrul E, Zaini E. Preparation and Physicochemical Characterization of Solid Dispersion of Irbesartan with Poloxamer 188. Open Access Maced J Med Sci [Internet]. 2020 Feb. 5 [cited 2024 May 26];8(A):16-9. Available from:

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