Evaluation of Homocysteine, Folic Acid and Vitamin B12 Levels among Egyptian Children with Idiopathic Epilepsy


  • Soha M. Abd El Dayem Pediatrics Department, National Research Centre, Cairo
  • Osama N. Saleh Pediatrics Department, Ain Shams University, Cairo
  • Nahed A. Emara Clinical Pathology Department, National Research Centre, Cairo
  • Manal E. Kandil Pediatrics Department, National Research Centre, Cairo
  • Rania H. Shatla Pediatrics Department, National Research Centre, Cairo
  • Sara Elgammal Pediatrics Department, National Research Centre, Cairo




homocysteine, folic acid, vitamin B12, epilepsy.


Objective: To evaluate relationship between homocysteine (Hcy), folic acid and vitamin B12 with anti-epileptic drugs in epileptic patients and their role in epilepsy control.

Patient and Methods: The study included 60 patients with idiopathic epilepsy and thirty non-epileptic children of the same age and sex served as controls. All cases were subjected to physical and neurological examination and electroencephalogram (EEG). Serum level of folic acid, homocysteine (Hcy) and vitamin B12 were done for both epileptic patients and controls. Non parametric test, one way ANOVA and Pearson’s correlation were used for analysis of data.

Result: 44 patients (73.3%) had generalized epilepsy and the remaining patients had partial epilepsy (simple or complex). 37 patients (61.6%) were in grade I, 3 patients (5 %) were in grade II and the remaining 20 patients (33.3 %) were in grade III epilepsy. Vitamin B12 was significantly higher in epileptic patients. Duration of anti-epileptic drug treatment was correlated significantly to folic acid and Hcy level.

Conclusion: antiepileptic drugs might upset the homeostatic balance of Hcy and its cofactors and cause abnormalities of their serum levels. The duration of anti-epileptic drug treatment was related to decrease of folic acid and increase in homocysteine levels.


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How to Cite

Abd El Dayem SM, Saleh ON, Emara NA, Kandil ME, Shatla RH, Elgammal S. Evaluation of Homocysteine, Folic Acid and Vitamin B12 Levels among Egyptian Children with Idiopathic Epilepsy. Open Access Maced J Med Sci [Internet]. 2014 Mar. 15 [cited 2021 Apr. 11];2(1):109-13. Available from: https://oamjms.eu/index.php/mjms/article/view



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