Correlation between HbA1c and Triglyceride Level with Coronary Stenosis Degree in Type 2 Diabetes Mellitus with Coronary Heart Disease


  • Laily Adninta Department of Clinical Pathology, Columbia Asia Hospital, Semarang, Central Java, Indonesia
  • Indranila Samsuria Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia
  • Edward Kurnia Setiawan Limijadi Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang, Central Java, Indonesia



HbA1c, Triglycerides, Coronary stenosis, Type 2 DM with CHD


BACKGROUND: The mortality of coronary heart disease (CHD) in type 2 diabetes mellitus (DM) increased 2–4 times more than non-diabetics because of coronary stenosis. One of the risk factors for CHD in type 2 DM is dyslipidemia. Hypertriglyceridemia plays an important role in atherosclerosis coronary arteries theoretically.

AIM: This study analyzed the parameters of HbA1c and triglyceride levels with the stenosis severity of coronary artery that occurs in type 2 DM patients with CHD that has not been analyzed so far.

METHODS: This study was a cross-sectional observational analytic study. Forty patients of type 2 DM with CHD in Kariadi Hospital on September 2013 were recruited based on the inclusion and exclusion criteria. HbA1c level in plasma was measured by turbidimetric immunoassay method. Triglyceride level was measured by enzymatic methods. Coronary stenosis was based on coronary angiography result as percentage. Spearman correlation test was used and p < 0.05 was considered statistically significant.

RESULTS: Mean HbA1c and triglyceride levels were 8.89 ± 1.498 % and 220.97 ± 92.24 mg/dL. The correlation test between HbA1c and triglycerides (TG) level with coronary stenosis, respectively, was p <0.001, r = 0.665; p = 0.001, r = 0.501. In addition, correlation between HbA1c and TG was p = 0.002, r = 0.466.

CONCLUSION: HbA1c and triglyceride levels increase in line with the increasing stenosis severity of coronary heart disease in patients with type 2 DM.


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Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends. J Epidemiol Glob Health. 2020; 10(1): 107–111. DOI:

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2012;35 Suppl 1:S64-71. PMid:22187472 DOI:

Association of Indonesian Endocrinologist (PERKENI). Diabetes Mellitus, Guideline of Management and Prevention of Type 2 DM in Indonesia. Jakarta: Association of Indonesian Endocrinologist (PERKENI); 2006.

Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4-14. PMid:19896746 DOI:

Sylvia PA. Glucose Metabolism and Diabetes Melitus, Pathophysiology. 6th ed., Vol. 2. Jakarta: EGC; 2006. p. 1260-65.

Stephen MJ, Ganong WF. Disorders of the Endocrine Pancreas, Pathophysiology of Disease. 5th ed. USA: Lange; 2006. p. 521-2.

Adam John MF. Reducing cardiovascular risk. In: Type 2 Diabetes from the Lipidologist View, Textbook of Diabetes and Related Disorders. Makassar: Perkeni; 2004. p. 1-2.

Einarson TR, Annabel, Ludwig C, Panton UH. Prevalence of Cardiovascular Disease in Type 2 Diabetes: A Systematic Literature Review of Scientific Evidence from Across The World in 2007–2017. Cardiovasc Diabetol. 2018; 17: 83. DOI:

Su G, Mi S, Tao H, Li Z, Yang H, Zheng H, et al. Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol. 2011;10:19. PMid:21349201 DOI:

Raghavan S, Vassy JL, Lam HY, Song RJ, Gagnon DR, Cho K, et al. Diabetes Mellitus–Related All-Cause and Cardiovascular Mortality in a National Cohort of Adults. J Am. Heart Assoc. 2019;8:e011295. DOI:

Lily IR. Coronary heart disease. In: Cardiovascular Disease. Jakarta; Publishing Center of Medical Faculty of University of Indonesia; 2012. p. 119-223.

Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111(25):3481-8. PMId:15983262 DOI:

Insull W Jr. The pathology of atherosclerosis: Plaque development and plaque responses to medical treatment. Am J Med. 2009;122 Suppl 1:S3-14. PMid:19110086 DOI:

Taskinen MR. Diabetic dyslipidemia: From basic research to clinical practice. Diabetologia. 2003;46(6):733-49. PMid:12774165 DOI:

Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest. 2000;106:453-8. PMid:10953019 DOI:

Sungkar MA. Triglycerides: A independent risk factor of coronary heart disease. In: Sutikno T, Sodiqur R, editors. Atherosclerosis. Semarang: Diponegoro University; 2003. p. 37-42.

Parhofer KG. Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia. Diabetes Metab J 2015;39:353-362. DOI:

Lee EJ, Kim YJ, Kim TN, Kim TI, Lee WK, Kim M, et al. A1c variability can predict coronary artery disease in patients with type 2 diabetes with mean A1c levels greater than 7. Endocrinol Metab. 2013;28(2):125-32. PMid:24396666 DOI:

Habib SS. Serum lipoprotein(a) and high sensitivity C reactive protein levels in Saudi patients with type 2 diabetes mellitus and their relationship with glycemic control. Turk J Med Sci 2013;43:333-8.

Ertem AG, Bagbanci H, Kilic H, Yeter E, Akdemir R. Relationship between HbA1c levels and coronary artery severity in nondiabetic acute coronary syndrome patients. Turk Kardiyol Dern Ars. 2013;41(5):389-95. PMid:23917003 DOI:

Yan Z, Liu Y, Huang H. Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients. Asian Pac J Trop Med. 2012;5(6):469-71. PMid:22575980 DOI:

Petitti DB, Imperatore G, Palla SL, Daniel SR, Dolan LM, Kershnar AK, et al. Serum lipids and glucose control. Arch Pediart Adolesc Med. 2007;161:159-65. PMid:17283301 DOI:

Saleem T, Mohammad KH, Abdel-Fattah MM, Abbasi AH. Association of glycosylated haemoglobin level and diabetes mellitus duration with the severity of coronary artery disease. Diabetes Vasc Dis Res. 2008;5(3):184-9. PMid:18777491 DOI:

Rivera JJ, Choi EK, Yoon YE, Chun EJ, Choi S, Nasir K, et al. Association between increasing levels of hemoglobin A1c and coronary atherosclerosis in asymptomatic individuals without diabetes mellitus. Coron Artery Dis. 2010;21(3):157-63. PMid:20308881 DOI:

Huo ZQ, Li HL, Gao L, Pan L, Zhao JJ, Li GW. Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Mol Cell Endrocinol. 2008;291(1-2):71-8. PMid:18485584 DOI:

Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes. 2003;52(11):2795-804. PMid:14578299 DOI:

Ceriello A, Esposito K, Piconi L, Ihnat MA, Thorpe JE, Testa R, et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes. 2008;57(5):1349-54. PMid:18299315 DOI:

Kim MK, Jung HS, Yoon CS, Ko JH, Jun HJ, Kim TK, et al. The effect of glucose fluctuation on apoptosis and function of INS-1 pancreatic beta cells. Korean diabetes J. 2010;34(1):47-54. PMid:20532020 DOI:

Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295(14):1681-7. PMid:16609090 DOI:

Ginsberg HN. Hypertriglyceridemia: New insight and new approaches to pharmacologic therapy. Am J Cardiol. 2001;87(10):1174-80. PMid:11356393 DOI:

Eckel RH. The metabolic syndrome. In: Jameson JL, editor. Harrison’s Endocrinology 2nd ed. Lancet: The McGraw-Hill Companies; 2010.

Sena CM , Pereira AM, Seiça R. Endothelial dysfunction - A Major Mediator Of Diabetic Vascular Disease. Biochimica et Biophysica Acta. 2013; 1832: 2216–2231. DOI:

Cullen P. Evidence that tryglycerides are an independent coronary heart disease risk factor. Am J Cardiol. 2000;86(9):943-9. PMid:11053704 DOI:

Gianturco SH, Bradley A. Pathophysiology of tryglyceride – Rich lipoprotein in atherothrombosis: Cellular aspect. Clin Cardiol. 1999;22 Suppl 6:II7-14. PMid:10376191 DOI:

Kohler HP, Grand PJ. Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med. 2000;342(24):1792-801. PMid:10853003 DOI:




How to Cite

Adninta L, Samsuria I, Limijadi EKS. Correlation between HbA1c and Triglyceride Level with Coronary Stenosis Degree in Type 2 Diabetes Mellitus with Coronary Heart Disease. Open Access Maced J Med Sci [Internet]. 2022 Apr. 29 [cited 2023 Sep. 27];10(B):944-8. Available from:

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