Relationship of Gastroesophageal Flap Valve with Gastroesophageal Reflux Disease Assessed Based on GerdQ Scores and Endoscopic Images

Authors

  • Andi Fithrani Neilufar Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Fardah Akil Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia image/svg+xml
  • Nu’man A. S. Daud Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia image/svg+xml
  • Syakib Bakri Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia image/svg+xml
  • Haerani Rasyid Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia image/svg+xml
  • Hasyim Kasim Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia image/svg+xml
  • Andi Makbul Aman Division of Metabolic Endocrine, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia image/svg+xml
  • Arifin Seweng Department of Biostatistics, Public Health Faculty, Hasanuddin University, Makassar, Indonesia image/svg+xml

DOI:

https://doi.org/10.3889/oamjms.2022.9817

Keywords:

Gastroesophageal reflux disease, Gastroesophageal reflux disease questionnaire, Reflux esophagitis, Helicobacter pylori, Body mass index

Abstract

Background: Gastroesophageal reflux disease (GERD) is a condition where reflux of stomach contents causes troublesome symptoms or complications. The gastroesophageal flap valve (GEFV) is one of the protective structures against esophageal reflux. This study aimed to determine the relationship between GEFV, measured by Gastroesophageal Reflux Disease Questionnaire (GerdQ) scores, and the endoscopic features of GERD patients.

Method: This observational cross-sectional study was performed at Wahidin Sudirohusodo Hospital Makassar from August 2021 to October 2021. The participants were GERD patients who met the inclusion criteria. They were diagnosed using GerdQ scores and endoscopic features based on the Los Angeles criteria. The GEFV was assessed using retroflection endoscopy according to Hill’s criteria. Data analysis used SPSS version 25. The Kolmogorov–Smirnov test was used to assess data normality, along with the Chi-square test and calculation of odds ratio (OR). The results of the statistical tests were significant if p<0.05.

Results: This study included 100 GERD patients: 49 men and 51 women. They had a mean age of 40.5±12.8 years and a mean body mass index of 22.4±3.8 kg/m2. Abnormal GEFV was a risk for a GerdQ score of ≥8 compared to <8 (OR 4.56; 95% CI 1.53–13.52). Both normal and abnormal GEFV in esophagitis reflux were higher than in non-erosive reflux disease (p=0.943).

Conclusion: Abnormal GEFV was a risk factor for GERD based on a GerdQ score of 8, at 4.56 times higher than with normal GEFV. No statistically significant relationship existed between GEFV and endoscopic images.

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Published

2022-05-12

How to Cite

1.
Neilufar AF, Akil F, Daud NAS, Bakri S, Rasyid H, Kasim H, Aman AM, Seweng A. Relationship of Gastroesophageal Flap Valve with Gastroesophageal Reflux Disease Assessed Based on GerdQ Scores and Endoscopic Images. Open Access Maced J Med Sci [Internet]. 2022 May 12 [cited 2024 Mar. 29];10(B):1991-5. Available from: https://oamjms.eu/index.php/mjms/article/view/9817

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Gastroenterohepatology

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