Multicenter Study: Effectiveness and Efficiency of Prabotulinum Toxin-A Injection on Wrinkles in Forehead, Crow’s Feet, and Glabellar

Sinta Murlistyarini; Adinda Amalia Dani; Lilik Norawati; Rita Maria; Abraham Arimuko; Arie Kusumawardani; Minna Hasniah

doi:10.3889/oamjms.2022.9834

Authors

Sinta Murlistyarini Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Regional Public Hospital dr. Saiful Anwar, Malang, Indonesia
Adinda Amalia Dani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Regional Public Hospital dr. Saiful Anwar, Malang, Indonesia
Lilik Norawati Department of Dermatology and Venereology, Presidential Gatot Soebroto Central Army Hospital, Jakarta, Indonesia
Rita Maria Department of Dermatology and Venereology, Presidential Gatot Soebroto Central Army Hospital, Jakarta, Indonesia
Abraham Arimuko Department of Dermatology and Venereology, Presidential Gatot Soebroto Central Army Hospital, Jakarta, Indonesia
Arie Kusumawardani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Regional Public Hospital dr. Moewardi, Surakarta, Indonesia
Minna Hasniah Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Regional Public Hospital dr. Moewardi, Surakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9834

Keywords:

Crow’s feet, Dynamic wrinkle, Forehead wrinkle glabellar wrinkle, Prabotulinumtoxin A

Abstract

BACKGROUND OF THE STUDY: Prabotulinumtoxin A (PRA) is the newest type A botulinum toxin produced by wild-type Clostridium botulinum. Prabotulinumtoxin A has a higher purity level than onabotulinum toxin A, but the literature discussing it is still limited and requires more research on its effectiveness.

AIM OF THE STUDY: This research aimed to examine the efficacy of Prabotulinumtoxin A on wrinkles in forehead, crow’s feet and glabellar.

METHODOLOGY: This research was a pre- and post-test, multicenter study from 3 center in Indonesia. Subjects will be observed at week 0, week 2, week 4, week 8 and week 12. Injection of prabotulinumtoxin A (INIBOÒ, Covaltt, South Korea) was performed intramuscularly on forehead, crow's feet, and glabellar with a dose of 4 IU / 0.1 ml. The measurement uses a scoring from the Upper Face Rating Scale. Different statistical test with repeated measurement test was conducted to compare the results between observations. The statistical test uses a confidence level of 0.95 with an error rate (α) = 0.05.

RESULTS: The results of this study showed that Prabotulinumtoxin A injection was effective in reducing wrinkles in the frontal, glabellar and crow's feet area, with a statistically significant difference between week 0 and week 12.

CONCLUSION: Prabotulinumtoxin A products improve the condition of wrinkles with a fairly good level of satisfaction and efficacy. Observations of more than 12 weeks are needed to determine the duration of Prabotulinumtoxin A products.

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