Multicenter Study: Effectiveness and Efficiency of Prabotulinum Toxin-A Injection on Wrinkles in Forehead, Crow’s Feet, and Glabellar

Authors

  • Sinta Murlistyarini Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Regional Public Hospital dr. Saiful Anwar, Malang, Indonesia
  • Adinda Amalia Dani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Regional Public Hospital dr. Saiful Anwar, Malang, Indonesia
  • Lilik Norawati Department of Dermatology and Venereology, Presidential Gatot Soebroto Central Army Hospital, Jakarta, Indonesia
  • Rita Maria Department of Dermatology and Venereology, Presidential Gatot Soebroto Central Army Hospital, Jakarta, Indonesia
  • Abraham Arimuko Department of Dermatology and Venereology, Presidential Gatot Soebroto Central Army Hospital, Jakarta, Indonesia
  • Arie Kusumawardani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Regional Public Hospital dr. Moewardi, Surakarta, Indonesia
  • Minna Hasniah Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Regional Public Hospital dr. Moewardi, Surakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9834

Keywords:

Crow’s feet, Dynamic wrinkle, Forehead wrinkle glabellar wrinkle, Prabotulinumtoxin A

Abstract

BACKGROUND OF THE STUDY: Prabotulinumtoxin A (PRA) is the newest type A botulinum toxin produced by wild-type Clostridium botulinum. Prabotulinumtoxin A has a higher purity level than onabotulinum toxin A, but the literature discussing it is still limited and requires more research on its effectiveness.

AIM OF THE STUDY: This research aimed to examine the efficacy of Prabotulinumtoxin A on wrinkles in forehead, crow’s feet and glabellar.

METHODOLOGY: This research was a pre- and post-test, multicenter study from 3 center in Indonesia. Subjects will be observed at week 0, week 2, week 4, week 8 and week 12. Injection of prabotulinumtoxin A (INIBOÒ, Covaltt, South Korea) was performed intramuscularly on forehead, crow's feet, and glabellar with a dose of 4 IU / 0.1 ml. The measurement uses a scoring from the Upper Face Rating Scale. Different statistical test with repeated measurement test was conducted to compare the results between observations. The statistical test uses a confidence level of 0.95 with an error rate (α) = 0.05.

RESULTS: The results of this study showed that Prabotulinumtoxin A injection was effective in reducing wrinkles in the frontal, glabellar and crow's feet area, with a statistically significant difference between week 0 and week 12.

CONCLUSION: Prabotulinumtoxin A products improve the condition of wrinkles with a fairly good level of satisfaction and efficacy. Observations of more than 12 weeks are needed to determine the duration of Prabotulinumtoxin A products.

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Published

2022-07-25

How to Cite

1.
Murlistyarini S, Dani AA, Norawati L, Maria R, Arimuko A, Kusumawardani A, Hasniah M. Multicenter Study: Effectiveness and Efficiency of Prabotulinum Toxin-A Injection on Wrinkles in Forehead, Crow’s Feet, and Glabellar. Open Access Maced J Med Sci [Internet]. 2022 Jul. 25 [cited 2024 Feb. 26];10(B):1927-31. Available from: https://oamjms.eu/index.php/mjms/article/view/9834

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