Pumpkin Seed Intervention to Control Diabetes Mellitus: A Systematic Review

Zhanaz Tasya; Ridwan Amiruddin; Aminuddin Syam; Yahya Thamrin

doi:10.3889/oamjms.2022.9850

Authors

Zhanaz Tasya Department of Epidemiology, Faculty of Public Health, Universitas Muhammadiyah Palu, City Palu, Indonesia
Ridwan Amiruddin Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Aminuddin Syam Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Yahya Thamrin Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9850

Keywords:

Intervention, Pumpkin seeds, Diabetes mellitus

Abstract

Background: In overcoming the problem of diabetes, developed countries have used herbal plants as an alternative treatment, considering that various types of synthetic drugs and available insulin therapy have physiological consequences in their use, such as insulin resistance, anorexia nervosa, brain atrophy, and fatty liver.

Objective: This article aims to identify pumpkin seed interventions in controlling diabetes mellitus

Methods: The article review was conducted using three bibliographic databases. Articles were selected based on 2011-2021 publications using the PRISMA flowchart of 2015

Results: A total of 1405 were obtained from three databases. About 17 articles according to the inclusion criteria and 7 articles were selected in this literature review. Based on the literature review results, it was found that previous researchers combined pumpkin seed with other plants to assess its efficacy in controlling blood glucose. Pumpkin seed had been tested on many experimental animals such as mice, rats, and rabbits. It showed hypoglycemic activity.

Conclusion: Pumpkin seed is an herbal plant that has advantages in preventing and maintaining health as well as being used as a complementary therapy for people with diabetes mellitus

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References

Centers for Disease Control and Prevention. Diabetes and Your Heart. Atlanta, Georgia, United States: Centers for Disease Control and Prevention; 2021. Available from: https://www.cdc.gov/diabetes/library/features/diabetes-and-heart.html [last accessed on 2022 Apr 18].

Heller SR, DeVries JH, Wysham C, Hansen CT, Hansen MV, Frier BM. Lower rates of hypoglycaemia in older individuals with Type 2 diabetes using insulin degludec versus insulin glargine U100: Results from SWITCH 2. Diabetes Obes Metab. 2019;21(7):1634-41. PMid:30891886

World Health Organization. Diabetes. Geneva: World Health Organization; 2021. Avaialble from: https://www.who.int/news-room/fact-sheets/detail/diabetes [Last accessed on 2022 Apr 18].

Oyedemi S, Bradley G, Afolayan A. Antidiabetic activities of aqueous stem bark extract of strychnoshenningsii gilg in streptozotocin-nicotinamide Type 2 diabetic rats. Iran J Pharm Res. 2012;11(1):221-8. PMid:24250443

Lusiana N, Prasetyaning L, Agustina E, Purnamasari R, Kumalasari ML, Kusumawati E, et al. Phytochemical, Haematinic and Antidiabetic Test of Pumpkin Extract (Cucurbita moschata). In: Surabaya, Indonesia: Proceedings of the Built Environment, Science and Technology International Conference; 2018. p. 103-7.

Adams GG, Imran S, Wang S, Mohammad A, Kok S, Gray DA, et al. The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines. Food Res Int. 2011;44(4):862-7.

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-9. PMid:18313558

Arzoo SH, Chattopadhyay K, Banerjee S, Chattopadhyay B. Synergistic improved efficacy of Gymnadenia orchidis root Salep and pumpkin seed on induced diabetic complications. Diabetes Res Clin Pract. 2018;146:278-288. PMid:30423348

Shim B, Jeong H, Lee S, Hwang S, Moon B, Storni C. A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life. J Funct Foods. 2014;8(1):111-7.

Gabal AM. Ameliorative activity of pumpkin (Cucurbita maxima) fruit and seeds powders on diabetic, oxidative and pancreatic status in rats. Int J Biochem Res Rev. 2019;26(2):1-9.

Makni M, Fetoui H, Gargouri NK, Garoui EM, Zeghal N. Antidiabetic effect of flax and pumpkin seed mixture powder: Effect on hyperlipidemia and antioxidant status in alloxan diabetic rats. J Diabetes Complications. 2011;25(5):339-45. PMid:21106396

Bharti SK, Kumar A, Sharma NK, Prakash O, Jaiswal SK, Krishnan S, et al. Tocopherol from seeds of Cucurbita pepo against diabetes: Validation by in vivo experiments supported by computational docking. J Formosan Med Assoc. 2013;112(11):676-90.

Teugwa CM, Boudjeko T, Tchinda BT, Mejiato PC, Zofou D. Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa. BMC Complement Altern Med. 2013;13:63.

Dotto JM, Chacha JS. The potential of pumpkin seeds as a functional food ingredient: A review. Sci Afr. 2020;10:e00575.

Devi M, Prasad RV, Sagarika N. A review on health benefits and nutritional composition of pumpkin seeds. Int J Chem Stud. 2018;6(3):1154-7.

Tánska M, Ogrodowska D, Bartoszewski G, Korzeniewska A, Konopka I. Seed lipid composition of new hybrids of styrian oil pumpkin grown in Poland. Agronomy. 2020;10(8):1104.

Abuelgassim AO, Al-Showayman SI. The effect of pumpkin (Cucurbita pepo L) seeds and L-arginine supplementation on serum lipid concentrations in atherogenic rats. Afr J Tradit Complement Altern Med. 2012;9(1):131-7. PMid:23983330

Alhakamy NA, Fahmy UA, Ahmed OA. Attenuation of benign prostatic hyperplasia by optimized tadalafil loaded pumpkin seed oil-based self nanoemulsion: In vitro and in vivo evaluation. Pharmaceutics. 2019;11(12):640. PMid:31805693

Nishimura M, Ohkawara T, Sato H, Takeda H, Nishihira J. Pumpkin seed oil extracted from Cucurbita maxima improves urinary disorder in human overactive bladder. J Tradit Complement Med. 2014;4(1):72-4. PMid:24872936

Abd-Elnoor E. Hypoglycemic and hypolipidemic effects of pumpkin seeds powder and oil on alloxan-induced diabetic in rats. Egypt J Food Sci. 2019;47:255-69.

Cuco RP, Massa TB, Postaue N, Cardozo-Filho L, da Silva C. Oil extraction from structured bed of pumpkin seeds and peel using compressed propane as solvent. J Supercrit Fluids. 2019;152:104568.

Rabrenović BB, Dimić EB, Novaković MM, Tešević VV, Basić ZN. The most important bioactive components of cold pressed oil from different pumpkin (Cucurbita pepo L.) seeds. LWT Food Sci Technol. 2014;55(2):521-7.

Departamento de Agricultura de Estados Unidos. FoodData Central. FoodData Central, Departamento de Agricultura de Estados Unidos; 2019.

Meru G, Fu Y, Leyva D, Sarnoski P, Yagiz Y. Phenotypic relationships among oil, protein, fatty acid composition and seed size traits in Cucurbita pepo. Sci Hortic 2018;233:47-53.

Benalia M, Djeridane A, Gourine N, Nia S, Ajandouz E, Yousfi M. Fatty acid profile, tocopherols content and antioxidant activity of algerian pumpkin seeds oil (Cucurbita pepo L). Mediterr J Nutr Metab. 2019;8(1):9-25.

Siano F, Straccia MC, Paolucci M, Fasulo G, Boscaino F, Volpe MG. Physico-chemical properties and fatty acid composition of pomegranate, cherry and pumpkin seed oils. J Sci Food Agric. 2016;96(5):1730-5. PMid:26033409

Bialek A, Bialek M, Jelinska M, Tokarz A. Fatty acid composition and characteristics of innovative edible oils in Poland. CYTA J Food. 2017;15(1):1-8.

Jafari M, Goli SA, Rahimmalek M. The chemical composition of the seeds of Iranian pumpkin cultivars and physicochemical characteristics of the oil extract. Eur J Lipid Sci Technol. 2012;114(2):161-7.

Rezig L, Chibani F, Chouaibi M, Dalgalarrondo M, Hessini K, Guéguen J, et al. Pumpkin (Cucurbita maxima) seed proteins: Sequential extraction processing and fraction characterization. J Agric Food Chem. 2013;61(32):7715-21. PMid:23869935

ODS. National Institute of Health. Pumpkins Seed Nutrition; 2016. Available from: https://fdc.nal.usda.gov/fdc-app.html#/food-details/170556/nutrients [Last accessed on 2021 May 25].

DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: A principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668. PMid:29387426

Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7(9):8199-226. PMid:26404370

Kostov K. Effects of magnesium deficiency on mechanisms of insulin resistance in Type 2 diabetes: Focusing on the processes of insulin secretion and signaling. Int J Mol Sci. 2019;20(6):1351. PMid:30889804

He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, et al. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006;113(13):1675-82. PMid:16567569

Rosique-Esteban N, Guasch-Ferré M, Hernández-Alonso P, Salas-Salvadó J. Dietary magnesium and cardiovascular disease: A review with emphasis in epidemiological studies. Nutrients. 2018;10(2):168. PMid:29389872

Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: Current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-33. PMid:23912329

Vashum KP, McEvoy M, Shi Z, Milton AH, Islam MR, Sibbritt D, et al. Is dietary zinc protective for Type 2 diabetes? Results from the Australian longitudinal study on women’s health. BMC Endocr Disord. 2013;13(1):40. PMid:24093747

Liu C, Song J, Teng M, Zheng X, Li X, Tian Y, et al. Antidiabetic and antinephritic activities of aqueous extract of cordyceps militaris fruit body in diet-streptozotocin-induced diabetic sprague dawley rats. Oxid Med Cell Longev. 2016;2016:9685257. PMid:27274781

Zhu HY, Chen GT, Meng GL, Xu JL. Characterization of pumpkin polysaccharides and protective effects on streptozotocindamaged islet cells. Chin J Nat Med. 2015;13(3):199-207. PMid:25835364

Zhang J, Zhao X, Zhao LQ, Zhao J, Qi Z, Wang LA. A primary study of the antioxidant, hypoglycemic, hypolipidemic, and antitumor activities of ethanol extract of brown slimecap mushroom, Chroogomphus rutilus (Agaricomycetes). Int J Med Mushrooms 2017;19(10):905-13. PMid:29256844

Ganesan K, Xu B. Anti-diabetic effects and mechanisms of dietary polysaccharides. Molecules. 2019;24(14):2556. PMid:31337059

Fathonah R, Indriyanti A, Kharisma Y. Pumpkin (Cucurbita moschata Durch.) for reducing fasting blood glucose levels in diabetic rats. Glob Med Health Commun. 2014;2(1):27-33.

Quanhong L, Caili F, Yukui R, Guanghui H, Tongyi C. Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats. Plant Foods Hum Nutr. 2005;60(1):13-6. PMid:15898354