Gender Associated High Body Mass Index in Allergic Diseases

Violeta Lokaj-Berisha; Besa Gacaferri-Lumezi; Ganimete Minciâ€“Bejtullahu; Hatixhe Latifi-Pupovci; Natyra Karahodaâ€“Gjurgjeala; Naser Berisha; Teuta Morina

doi:10.3889/oamjms.2015.008

Authors

Violeta Lokaj-Berisha Department of Physiology & Immunology, Faculty of Medicine, University of Prishtina, Prishtina
Besa Gacaferri-Lumezi Department of Physiology & Immunology, Faculty of Medicine, University of Prishtina, Prishtina
Ganimete Minciâ€“Bejtullahu Department of Physiology & Immunology, Faculty of Medicine, University of Prishtina, Prishtina
Hatixhe Latifi-Pupovci Department of Physiology & Immunology, Faculty of Medicine, University of Prishtina, Prishtina
Natyra Karahodaâ€“Gjurgjeala Department of Physiology & Immunology, Faculty of Medicine, University of Prishtina, Prishtina
Naser Berisha Department of Obstetrics and Gynecology, University Clinical Center, Prishtina
Teuta Morina Faculty of Medicine, University of Prishtina, Prishtina

DOI:

https://doi.org/10.3889/oamjms.2015.008

Keywords:

allergy, atopy, body mass index, gender, total IgE, Republic of Kosovo

Abstract

BACKGROUND:The increasing prevalence of allergic diseases and atopy is affected by sex, age and lifestyle factors. Obesity and excess weight are reported to be potential risk factors for atopy and specifically for asthma symptoms in children and adults.

OBJECTIVE:To assess the relation between body mass index (BMI) and allergic diseases in patients of both genders, as well as association of BMI with atopy in healthy subjects.

METHODS:BMI (kg/m²), skin-prick test and total serum immunoglobulin E levels were assessed in 139 subjects: 109 were patients with allergic diseases (M to F ratio was 51:58) and 30 were healthy controls (M to F ratio was 6:24).

RESULTS:The study population was grouped into asthma, asthmarhinitis, rhinitis, Urticaria oreczema and controls by BMI and sex. Females with the highest BMI were in asthma and urticaria/eczema group. Males with the highest BMI were in asthmarhinitis and urticariaeczema group. High BMI was associated with atopy in both genders of healthy controls. High levels of total IgE were in male allergic patients.

CONCLUSION:High BMI was associated with asthma in females, urticaria/eczema in both genders and atopy in both genders of healthy controls. Higher levels of total IgE were concluded in male patients.

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References

Gorgievska-Sukarovska B, LipozenciÄ‡ J, Susac A. Obesity and allergic diseases. Acta Dermatovenerol Croat. 2008; 16:231-5.

Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007; 62:1205-13. DOI: https://doi.org/10.1111/j.1398-9995.2007.01506.x

Yuksel H, Sogut A, Yilmaz O, Onur E, Dinc G. Role of Adipokines and Hormones of Obesity in Childhood Asthma. Allergy Asthma Immunol Res. 2012; 4: 98â€“103. DOI: https://doi.org/10.4168/aair.2012.4.2.98

Sierra-Honigmann MR, Nath AK, Murakami C, GarcÃa-CardeÃ±a G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, et al. Biological action of leptin as an angiogenic factor. Science. 1998; 28:1683â€“6. DOI: https://doi.org/10.1126/science.281.5383.1683

Gurkan F, Atamer Y, Ece A, Kocyigit Y, Tuzun H, Mete N. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol. 2004; 93:277â€“80. DOI: https://doi.org/10.1016/S1081-1206(10)61501-3

Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004; 50:1511â€“25. DOI: https://doi.org/10.1373/clinchem.2004.032482

Ciprandi G, Brambilla I, Tosca MA, Arrigo T, Salpietro A, Leonardi S, La Rosa M, Marseglia GL. Body mass index is related with bronchial function and reversibility in children with allergic rhinitis and asthma. Int J Immunopathol Pharmacol. 2011; 24:21-4. DOI: https://doi.org/10.1177/03946320110240S405

Yao TC, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study. J Asthma. 2011; 48:503-10. DOI: https://doi.org/10.3109/02770903.2011.576743

Ruotsalainen M, Sidoroff V, Piippo-Savolainen E, HyvÃ¤rinen MK, Korppi M. Association between overweight and asthma or allergy: Results from a prospective 27-year post-bronchiolitis follow-up. Curr Pediatr Res. 2012; 16: 95-100.

BrÃ¥bÃ¤ck L, Hjern A, Rasmussen F. Body mass index, asthma and allergic rhinoconjunctivitis in Swedish conscriptsâ€”a national cohort study over three decades. Respiratory Medicine. 2005; 99:1010-1014. DOI: https://doi.org/10.1016/j.rmed.2005.02.004

Silverberg JI, Silverberg NB, Lee-Wong M. Association between atopic dermatitis and obesity in adulthood. Br J Dermatol. 2012; 166:498-504. DOI: https://doi.org/10.1111/j.1365-2133.2011.10694.x

Lokaj-Berisha V, Berisha N, Lumezi B, Ahmetaj L, Bejtullahu G, Karahoda N, H Pupovci. Sensitization to Aeroallergens in Patients with Respiratory AllerÂ¬gies Based on Skin-Prick Test Results. Iranian J Publ Health. 2012; 41:29-35.

Lee JH, Lee WY, Yong SJ, Shin KCh, Lee ShN, Lee SJ, Kim CW, Jung S, Jung YR, Kim SH..[Relationship between Body Mass Index and Serum Total IgE in Adult Patients with Nonatopic Respiratory Allergy]. Korean J Asthma Allergy Clin Immunol. 2011;31:288-94. Korean.

Borish L, Chipps B, Deniz Y, Gujrathi Sh, Zheng B, Dolan ChM; Tenor study group. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2005; 95:247-53. DOI: https://doi.org/10.1016/S1081-1206(10)61221-5

Abut L, Ozerol I, Apan T. Total and Specific IgE in the Sera of Patients With Asthma, Urticaria or Allergic Rhinitis From the Southeast Anatolia Region of Turkey. Lab Med. 2007; 38:621-23. DOI: https://doi.org/10.1309/7AUYDXTDYFPKPMD4

Ho WC, Lin YS, Caffrey JL, Lin MH, Hsu HT, Myers L, Chen PCh, Lin RSh. Higher body mass index may induce asthma among adolescents with pre-asthmatic symptoms: a prospective cohort study. BMC Public Health. 2011; 11:542. DOI: https://doi.org/10.1186/1471-2458-11-542

Luder E, Ehrlich RI, Lou WY, Melnik TA, Kattan M. Body mass index and the risk of asthma in adults. Respir Med. 2004; 98:29-37. DOI: https://doi.org/10.1016/j.rmed.2003.08.004

Chen Y, Dales R, Tang M, Krewski D. Obesity May Increase the Incidence of Asthma in Women but Not in Men: Longitudinal Observations from the Canadian National Population Health Surveys. Am J Epidemiol. 2002; 155:191-7. DOI: https://doi.org/10.1093/aje/155.3.191

Hankinson SE, Willett WC, Manson JE, Hunter DJ, Colditz GA, Stampfer MJ, Longcope C, Speizer FE. Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. J Natl Cancer Inst. 1995; 87:1297â€“302. DOI: https://doi.org/10.1093/jnci/87.17.1297

Leenen R, van der Kooy K, Seidell JC, Deurenberg P, Koppeschaar HP. Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab. 1994; 78:1515â€“20. DOI: https://doi.org/10.1210/jcem.78.6.8200956

Joseph CL, Havstad SL, Ownby DR, Zoratti E, Peterson EL, Stringer S, Johnson CC. Gender differences in the association of overweight and asthma morbidity among urban adolescents with asthma. Pediatr Allergy Immunol. 2009; 20: 362-9. DOI: https://doi.org/10.1111/j.1399-3038.2008.00803.x

Luo X, Xiang J, Dong X, Cai F, Suo J, Wang Z, Liu M. Association between obesity and atopic disorders in Chinese adults: an individually matched caseâ€“control study. BMC Public Health. 2013;13:12. DOI: https://doi.org/10.1186/1471-2458-13-12

Flexeder C, BrÃ¼ske I, Magnussen H, Heinrich J. Association between obesity and atopy in adults? Int Arch Allergy Immunol. 2011; 156:117-8. DOI: https://doi.org/10.1159/000322296

Jarvis D, Chinn S, Potts J, Burney P. Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey. Clin Exp Allergy. 2002; 32:831-7. DOI: https://doi.org/10.1046/j.1365-2222.2002.01380.x

Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR. Elevated atopy in healthy obese women. Am J Clin Nutr. 2005; 82:504-9. DOI: https://doi.org/10.1093/ajcn/82.3.504

Hancox RJ, Milne BJ, Poulton R, Taylor DR, Greene JM, McLachlan CR, Cowan JO, Flannery EM, Herbison GP, Sears MR. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med. 2005;171:440-5. DOI: https://doi.org/10.1164/rccm.200405-623OC

Kirschner MA, Samojlik E, Drejka M, Szmal E, Schneider G, Ertel N. Androgen-estrogen metabolism in women with upper body versus lower body obesity. J Clin Endocrinol Metab. 1990; 70:473-9. DOI: https://doi.org/10.1210/jcem-70-2-473

Gallagher D, Visser M, Sepulveda D, Pierson RN, Harris T, Heymsfield SB. How useful is body mass index for comparison of body fatness across age, sex, and ethnic groups? Am J Epidemiol. 1996;143:228â€“9. DOI: https://doi.org/10.1093/oxfordjournals.aje.a008733

Criqui MH, Seibles JA, Hamburger RN, Coughlin SS, Gabriel S. Epidemiology of immunoglobulin E levels in a defined population. Ann Allergy. 1990; 64:308-13.

Kerkhof M, Droste JHJ, de MonchyJGR, Schouten JP, Rijcken B. Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20-70 years. Allergy. 1996; 51:770-6. DOI: https://doi.org/10.1111/j.1398-9995.1996.tb00021.x