Predictors of High Serum Casein Antibody Levels among Malnourished Infants and Young Children with Congenital Heart Disease


  • Inas R. El-Alameey National Research Centre, Child Health Department, Dokki, Cairo
  • Hanaa Ahmed National Research Centre, Hormones, Dokki, Cairo
  • Zeinab Monir National Research Centre, Child Health Department, Dokki, Cairo
  • Thanaa Rabah National Research Centre, Public Health and Community Medicine Department, Dokki, Cairo
  • Ayman M. Abdel Gawad National Research Centre, Child Health Department, Dokki, Cairo



congenital heart disease, serum casein antibody, malnourished infants, young children, predictors


BACKGROUND: Factors predictive of growth retardation and malnutrition in patients with congenital heart disease remain unclear.

OBJECTIVES: This study aimed to measure antibody response to bovine casein through assessing serum casein antibody levels in malnourished patients three year or younger with CHD, and to determine its relationship to gastrointestinal symptoms, anthropometric measures, and laboratory data.

SUBJECTS AND METHODS: This cross sectional case control study was conducted in sixty patients with CHD aged 4 to 72 months. They were subdivided into thirty patients with cyanotic and thirty patients with acyanotic CHD compared with thirty apparently healthy children.

RESULTS: On comparison with controls, patients showed highly significant lower anthropometric measures, calcium, iron, hemoglobin levels, and higher serum levels of casein antibody, total iron binding capacity, and alkaline phoshatase activity (P<0.000). Serum levels of casein antibody showed significantly positive correlations with serum total iron binding capacity and alkaline phosphatase activities and negatively correlated with the age at onset of symptoms, anthropometric measures, serum calcium, and iron levels.

CONCLUSION: Serum casein antibody levels play a significant role in the pathogenesis of malnutrition. Encouragement of breast feeding and avoidance of early cow's milk consumption could prevent the development of antibody response to bovine casein.


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How to Cite

El-Alameey IR, Ahmed H, Monir Z, Rabah T, Abdel Gawad AM. Predictors of High Serum Casein Antibody Levels among Malnourished Infants and Young Children with Congenital Heart Disease. Open Access Maced J Med Sci [Internet]. 2015 Jan. 22 [cited 2022 Aug. 15];3(1):91-8. Available from:



B - Clinical Sciences

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