Predictive Factors for the Effect of Treatment by Noninvasive Ventilation in Patients with Respiratory Failure as a Result of Acute Exacerbation of the Chronic Obstructive Pulmonary Disease

Sava Pejkovska; Biserka Jovkovska Kaeva; Zlatica Goseva; Zoran Arsovski; Jelena Jovanovska Janeva; Sead Zeynel

doi:10.3889/oamjms.2015.115

Authors

Sava Pejkovska University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Biserka Jovkovska Kaeva University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Zlatica Goseva University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Zoran Arsovski University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Jelena Jovanovska Janeva University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Sead Zeynel University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2015.115

Keywords:

COPD, noninvasive ventilation, respiratory failure, predictive factors, COPD exacerbation

Abstract

BACKGROUND: Noninvasive mechanical ventilation (NIV) applies ventilator support through the patientâ€™s upper airway using a mask.

AIM: The aim of the study is to define factors that will point out an increased risk of NIV failure in patients with exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

PATIENTS AND METHODS: Patients over the age of 40, treated with NIV, were prospectively recruited. After data processing, the patients were divided into two groups: 1) successful NIV treatment group; 2) failed NIV treatment group.

RESULTS: On admission arterial pH and Glasgow coma scale (GCS) levels were lower (pH: p < 0.05, GCS: p < 0.05), and Acute Physiology and Chronic Health Evaluation II (APACHE) score and PaCO₂ were higher (p < 0.05) in the NIV failure group. Arterial pH was lower (p < 0.05) and PaCO₂and respiratory rate were higher (p < 0.05) after 1h, and arterial pH was lower (p < 0.05) and PaCO₂ (p < 0.05), respiratory and heart rate were higher (p < 0.05) after 4h in the NIV failure group.

CONCLUSION: Measurement and monitoring of certain parameters may be of value in terms of predicting the effectiveness of NIV treatment.

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