Gastroesophageal Reflux Symptoms in Patients with Chronic Obstructive Pulmonary Disease

Zlatica Goseva; Angelko Gjorcev; Elena Jovanovska-Janeva; Suzana Arbutina

doi:10.3889/oamjms.2014.080

Authors

Zlatica Goseva University Clinic of Pulmology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Angelko Gjorcev University Clinic of Pulmology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Elena Jovanovska-Janeva University Clinic of Pulmology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Suzana Arbutina University Clinic of Pulmology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2014.080

Keywords:

GER symptoms, COPD, airway obstruction, FEV1, dyspnea.

Abstract

BACKGROUND: It is known that there is some relation between airways obstruction and gastroesophageal reflux symptoms (GER) symptoms in patients with chronic obstructive pulmonary disease (COPD).

AIM: The aim was to determine frequency of GER symptoms and correlation with pulmonary function tests in patients with COPD.

MATERIAL AND METHODS: The study included 58 patients. First group had 20 patients with mild COPD, second group had 18 patients with moderate COPD and third group had 20 patients with severe COPD. We had also a control group with 12 healthy subjects. All subjects completed their self-reported questionnaire about symptoms like: acid-regurgitation, heartburn, dysphagia, dyspnea and chronic cough.

RESULTS: COPD patients with airways obstruction and significant GER symptoms had their respiratory symptoms associated with reflux events. More of COPD patients had significant GER symptoms defined as regurgitation and dysphagia once or more per week. Patients with FEV₁less than 50% showed more prevalent GER symptoms compared to those with values of FEV₁ grater then 50%.

CONCLUSION: GER symptoms are more prevalent in patients with severe airways obstruction when compared to less airways obstructed group and controls. We could suggest an association between the degree of airways obstruction in patients with COPD and the increased rate of GER symptoms.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

GOLD. Global initiative for chronic Obstructive Lung Disease. Global strategy for diagnosis, management and prevention of chronic obstructive lung disease. Gold website, www.gold COPD.org.2013.

Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, Schmid V, Buist S. Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J. 2006;27(2):397-412. DOI: https://doi.org/10.1183/09031936.06.00025805

Rascon-Aguilar IE, Pamer M, Wludyka P, Cury J, Coultas D, Lambiase LR, Nahman NS, Vega KJ. Role of gastroesophageal reflux symptoms in exacerbations of COPD. Chest. 2006;130(4):1096-101. DOI: https://doi.org/10.1378/chest.130.4.1096

DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005;100: 190-200. DOI: https://doi.org/10.1111/j.1572-0241.2005.41217.x

Mokhlesi B, Morris AL, Huang CF, Curcio AJ, Barrett TA, Kamp DW. Increased prevalence of gastroesophageal reflux symptoms in patients with COPD. Chest. 2001;119(4):1043-8. DOI: https://doi.org/10.1378/chest.119.4.1043

Highland KB, Harding SM. GERD-Related Lung Disease. Practical Gastroenterology. 2005; 74-80.

Havemann BD, Henderson CA, el-Serag HB. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut. 2007;56(12):1654-1664. DOI: https://doi.org/10.1136/gut.2007.122465

Harding SM. Recent clinical investigations examining the association of asthma and gastroesophageal reflux. Am J Med. 2003;115:39Sâ€“44S. DOI: https://doi.org/10.1016/S0002-9343(03)00191-8

Acdel Khattab, Khaled El-Karmouty, Tamer Aly, Asmaa Abdel Azeem. Study of gastro-esophageal reflux disease in COPD patients. Egyptian Journal of Bronchology. 2008; 2(2): 253-260.

Casanova C, Baudet JS, del Vale Velasco M, Martin JM, Aquirre-Jaime A, de Torres JP, Celli BR. Increased gastro-oesophageal reflux disease in patients with severe COPD. Eur Resp J. 2004; 23(6):841-5. DOI: https://doi.org/10.1183/09031936.04.00107004

Phulpoto MA, Oayyum S, Rizvi N, Khuhaw SM. Proportion of gastroesophageal reflux symptoms in patients with chronic obstructive pulmonary disease. J Pak Med Assoc. 2005: 55(7):276-9.

Gaude GS. Pulmonary manifestations of gastroesophageal reflux disease. Ann Thorac Med. 2009;4(3):115-23. DOI: https://doi.org/10.4103/1817-1737.53347

GarcÃa RodrÃguez LA, RuigÃ³mez A, MartÃn-Merino E, Johansson S, Wallander MA. Relationship between gastroesophageal reflux disease and COPD in UK primary care. Chest. 2008;134(6):1223-30. DOI: https://doi.org/10.1378/chest.08-0902

Liang BM, Feng YL. Association of gastroesophageal reflux disease symptoms with stable chronic obstructive pulmonary disease. Lung. 2012;190(3):277-82. DOI: https://doi.org/10.1007/s00408-011-9365-5

Kampainen RR, Savik K, Whelan TP et al. High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD. Chest. 2007;131(6):1666-1671. DOI: https://doi.org/10.1378/chest.06-2264

Terada K, Muro S, Sato S et al. Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. Thorax. 2008;63(11):951-955. DOI: https://doi.org/10.1136/thx.2007.092858

Shimizu Y, Dobashi K, Kusano M, Mori M. Different gastoroesophageal reflux symptoms of middle-aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients. J Clin Biochem Nutr. 2012;50(2):169-75. DOI: https://doi.org/10.3164/jcbn.11-75