Relationship between Vitamin D, Inflammation and Lung Function In Patients with Severe Uncontrolled Asthma

Elena Janeva-Jovanovska; Dejan Dokic; Biserka Jovkovska-Kaeva; Gorica Breskovska; Zlatica Goseva; Jordan Minov; Dejan Trajkov; Magdalena Dimitrova-Genadieva; Beti Zafirovska-Ivanovska

doi:10.3889/oamjms.2017.190

Authors

Elena Janeva-Jovanovska PHI University Clinic of Pulmonology and Allergy, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Dejan Dokic PHI University Clinic of Pulmonology and Allergy, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Biserka Jovkovska-Kaeva PHI University Clinic of Pulmonology and Allergy, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Gorica Breskovska PHI University Clinic of Pulmonology and Allergy, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Zlatica Goseva PHI University Clinic of Pulmonology and Allergy, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Jordan Minov Institute for Occupational Health of RM - Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Dejan Trajkov Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Magdalena Dimitrova-Genadieva PHI University Clinic of Gastroenterohepatology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
Beti Zafirovska-Ivanovska Institute of Epidemiology and Biostatistics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2017.190

Keywords:

asthma, Vitamin D, IL-33, FEV1, Th2-type cytokines

Abstract

BACKGROUND: Recently epidemiological studies showed that low vitamin D is linked to airway hyperresponsiveness, decreased lung function, poor asthma control, and steroidâ€“resistant asthma.

AIM: We investigated the relationship between Vitamin D, inflammation with circulating IL-33 and lung function in 30 patients with severe uncontrolled asthma.

MATERIALS AND METHODS: The study included 30 patients with severe uncontrolled asthma. In each of them were measured serum levels of IL-33 and Vitamin D by the ELISA method. The pulmonary function is measured by basic spirometry parameters, FEV1. The results were statistically elaborated according to the Pearsonâ€™s Correlation Tests.

RESULTS: The results showed statistically insignificant correlation between Vitamin D and IL-33, and Vitamin D with FEV1 (Vit.D/IL-33; r = 0.11323, p = 0.551); (Vit.D/FEV1; r = -0.1005; p = 0.597) Correlation between IL-33 and FEV1 is negative but statistically significant (IL-33/FEV1; r = -0.5248; p = 0.003).

CONCLUSION: Because there are little studies about the link between vitamin D and asthma, further research to clarify the mechanism how vitamin D control the activity of CD4+ T cells and the related Th2-type cytokines in the parthenogenesis of asthma.

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