Hormonal Perturbations in Occupationally Exposed Nickel Workers
DOI:
https://doi.org/10.3889/oamjms.2016.046Keywords:
Nickel, FSH, LH, Testosterone, sexual problemsAbstract
BACKGROUND: Nickel exposure is recognized as an endocrine disruptor because of its adverse effects on reproduction.
AIM: This study was designed to investigate the possible testiculo-hormonal perturbations on workers occupationally exposed to nickel and to assess its effects on human male sexual function.
METHODS: Cross-sectional comparative study, comprising 105 electroplating male non-smoker, non-alcoholic workers exposed to soluble nickel and 60 controls was done. Serum luteinizing hormone, follicle stimulating hormone, testosterone levels and urinary nickel concentrations were determined for the studied groups.
RESULTS: Serum luteinizing hormone, follicle stimulating hormone, urinary nickel and the simultaneous incidence of more than one sexual disorder were significantly higher in the exposed workers compared to controls. The occurrence of various types of sexual disorders (decreased libido, impotence and premature ejaculation) in the exposed workers was 9.5, 5.1 and 4.4 folds respectively than the controls.
CONCLUSIONS: Exposure to nickel produces possible testiculo-hormonal perturbations in those exposed workers.Downloads
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Toppari J, Larsen JC, Christiansen P, et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect. 1996;104 (4):741-803.
http://dx.doi.org/10.1289/ehp.96104s4741
PMid:8880001 PMCid:PMC1469672
Working PK. Male reproductive toxicology: comparison of the human to animal models. Environ Health Perspect. 1988;77:37–44.
http://dx.doi.org/10.1289/ehp.887737
PMid:3289906 PMCid:PMC1474524
Arita A, Niu J, Qu Q et al. Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel. Environ Health Perspect. 2012; 120:198–203.
http://dx.doi.org/10.1289/ehp.1104140
PMid:22024396 PMCid:PMC3279455
IARC. Chromium, nickel and welding. IARC Monogr Eval Carcinog Risks Hum. 1990; 49:1–648.
PMid:2232124
HSDB. Fact Sheet" Hazardous Substances Data Bank." National Library of Medicine. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen? HSDB and search on CAS number. Last accessed: 10/22/2009.
Kakela R, Kakela A, Hyvarinen H. Effects of nickel chloride on reproduction of the rat and possible antagonistic role of selenium. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999; 123:27–37.
http://dx.doi.org/10.1016/S0742-8413(99)00006-7
Obone E, Chakrabarti SK, Bai C et al. Toxicity and bioaccumulation of nickel sulfate in Sprague-Dawley rats following 13 weeks of subchronic exposure. J Toxicol Environ Health. 1999;57:379–401.
http://dx.doi.org/10.1080/009841099157593
Das KK, Dasgupta S. Effect of nickel on testicular nucleic acid concentrations of rats on protein restriction. Biol Trace Elem Res. 2000;73:175–180.
http://dx.doi.org/10.1385/BTER:73:2:175
Kong L, Tang M, Zhang T, et al. Nickel nanoparticles exposure and reproductive toxicity in healthy adult rats. Int J Mol Sci. 2014;15(11):21253-69.
http://dx.doi.org/10.3390/ijms151121253
PMid:25407529 PMCid:PMC4264223
Danadevi K, Rozati R, Reddy PP, et al. Semen quality of Indian welders occupationally exposed to nickel and chromium. Reprod Toxicol. 2003;17:451–456.
http://dx.doi.org/10.1016/S0890-6238(03)00040-6
Hjollund NH, Bonde JP, Jensen TK et al. Semen quality and sex hormones with reference to metal welding. Reprod Toxicol. 1998; 12(2):91-5.
http://dx.doi.org/10.1016/S0890-6238(97)00156-1
Stinson TJ, Jaw S, Jeffery EH, et al. The relationship between nickel chloride-induced peroxidation and DNA strand breakage in rat liver. Toxicol Appl Pharmacol. 1992;117:98–103.
http://dx.doi.org/10.1016/0041-008X(92)90222-E
Chen CY, Huang YL, Lin TH. Association between oxidative stress and cytokine production in nickel-treated rats. Arch Biochem Biophys. 1998;356:127–132.
http://dx.doi.org/10.1006/abbi.1998.0761
PMid:9705202
Gupta AD, Dhundasi SA, Ambekar JG, et al. Effect of Lascorbic acid on antioxidant defense system in testes of albino rats exposed to nickel sulphate. J Basic Clin Physiol Pharmacol 2007; 18:87-95.
http://dx.doi.org/10.1515/JBCPP.2007.18.4.255
Das KK, Buchner V. Effect of nickel exposure on peripheral tissues: Role of oxidative stress in toxicity and possible protection by ascorbic acid. Rev Environ Health. 2007; 22:133-49.
http://dx.doi.org/10.1515/REVEH.2007.22.2.157
Sun Y, Ou Y, Cheng M et al. Binding of nickel to testicular glutamate-ammonia ligase inhibits its enzymatic activity. Mol Reprod Dev. 2011; 78(2):104-15.
http://dx.doi.org/10.1002/mrd.21275
PMid:21254280
Wirth JJ, Mijal RS. Adverse effects of low level heavy metal exposure on male reproductive function. Syst Biol Reprod Med. 2010;56(2):147-67.
http://dx.doi.org/10.3109/19396360903582216
PMid:20377313
Apostoli P, Catalani S. Metal ions affecting reproduction and development. Met Ions Life Sci. 2011;8:263-303.
PMid:21473384
Pizent A, Tariba B, Živković T. Reproductive toxicity of metals in men. Arh Hig Rada Toksikol. 2012; 63(1):35-46.
http://dx.doi.org/10.2478/10004-1254-63-2012-2151
Gronowski AM, Landau-Levine M. Reproductive endocrine function. In Burtis CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry 5th ed. Philadelphia, Pa: WB Saunders, 1999:877-78.
Waissmann W. Health surveillance and endocrine disruptors. Cad Saúde Pública. 2002; 18:511-17.
http://dx.doi.org/10.1590/S0102-311X2002000200016
PMid:11923893
Nelson P. Epidemiology, biology, and endocrine disrupters. Occup Environ Med. 2003; 60:541-42.
http://dx.doi.org/10.1136/oem.60.8.541
PMid:12883013 PMCid:PMC1740595
Eliades T, Pratsinis H, Kletsas D et al. Characterization and cytotoxicity of ions released from stainless steel and nickel-titanium orthodontic alloys. Am J Orthod Dentofacial Orthop. 2004; 125:24–29.
http://dx.doi.org/10.1016/j.ajodo.2003.09.009
Long-zhu J, Zhe-ming N. Determination of nickel in urine and other biological samples by graphite furnace atomic absorption spectrometry. Fresenius' Zeitschrift für analytische Chemie. 1985; 321:72-76.
http://dx.doi.org/10.1007/BF00464491
Baxmann AC, Ahmed MS, Marques NC, et al. Influence of Muscle Mass and Physical Activity on Serum and Urinary Creatinine and Serum Cystatin C. Clin J Am Soc Nephrol. 2008; 3(2):348–54.
http://dx.doi.org/10.2215/CJN.02870707
PMid:18235143 PMCid:PMC2390952
Bartels H. Determination of serum and urinary creatinine by Jaffe s method without deproteinsation in a 2-point reaction rate measurement in 2 minutes. Clin Chim Acta. 1971;.32: 81-84.
ATSDR. Toxicological Profile for Nickel. Agency for Toxic Substances and Disease Registry.1997. http://www.atsdr.cdc.gov/toxprofiles/tp15.pdf. 293 pp
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Nickel. Atlanta, GA: U.S. Department of Health and Human Services, Public Human Service, 2005.
Savolainen H. Biochemical and clinical aspects of nickel toxicity. Rev Environ Health. 1996; 11:167-73.
http://dx.doi.org/10.1515/REVEH.1996.11.4.167
PMid:9085432
Campurra G. Agenti chimici. In: Manuale medicina del lavoro. Italy: Wolters Kluwer, 2010; 868-69.
De Sio S, Casale T, Rosati MV et al. Correlation between urinary nickel and FSH plasma values in workers occupationally exposed to urban stressors. Prevention and research. 2013; 2 (4):131–40.
http://dx.doi.org/10.11138/pr/2013.2.4.131
Sancini A, De Sio S, Gioffrè PA et al. Correlation between urinary nickel and testosterone plasma values in workers occupationally exposed to urban stressors. Ann Ig. 2014; 26(3):237-54.
PMid:24998215
Steinberger E. Current status of studies concemed with evaluation of toxic effects of chemicals on the testes. Environ Health Perpect. 1981;38:29-33.
http://dx.doi.org/10.1289/ehp.813829
Lukac N, Bardos L, Stawarz R et al. In vitro effect of nickel on bovine spermatozoa motility and annexin V-labeled membrane changes. J Appl Toxicol. 2011; 31(2): 144-9.
PMid:20737413
Murawska-Ciałowicz E, Bal W, Januszewska L, et al. Oxidative stress level in the testes of mice and rats during nickel intoxication.Scientific World Journal. 2012; 2012: 395741
http://dx.doi.org/10.1100/2012/395741
PMid:22448131 PMCid:PMC3290116
Rodamilans M, Martinez-Osaba MJ, To-Figueras J, et al. Inhibition of intratesticular testosterone synthesis by inorganic lead. Toxicol Lett. 1988; 42 (3): 285-390.
http://dx.doi.org/10.1016/0378-4274(88)90113-0
Yang Y, Lu XS, Li DL, et al. Effects of environmental lead pollution on blood lead and sex hormone levels among occupationally exposed group in an E-waste dismantling area. Biomed Environ Sci. 2013; 26 (6): 474-84.
PMid:23816581
Sexual Dysfunction in Males - Cleveland Clinic http://my.clevelandclinic.org/health/diseases_conditions/hic_An_Overview_of_Sexual_Dysfunction/hic_Sexual_Dysfunction_in_Males
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