Comparative Hepatotoxicity of Aflatoxin B1 among Workers Exposed to Different Organic Dust with Emphasis on Polymorphism Role of Glutathione S-Transferase Gene

Authors

  • Amal Saad-Hussein Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Eman M. Shahy Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Weam Shaheen Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Mona M. Taha Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Heba Mahdy-Abdallah Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Khadiga S. Ibrahim Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Salwa F. Hafez Department of Environmental & Occupational Medicine, National Research Centre, Cairo
  • Nevein N. Fadl Department of Medical Physiology, National Research Centre, Cairo
  • Karima A. El-Shamy Department of Medical Physiology, National Research Centre, Cairo

DOI:

https://doi.org/10.3889/oamjms.2016.051

Keywords:

Organic dust, Aflatoxin B1, Liver enzymes, GST polymorphism

Abstract

AIM: The study aimed to investigate effects of organic dust exposure from different sources on aflatoxin B1-albumin adducts (AFB1/Alb), and role of glutathione S-transferase (GST) gene polymorphism in hepatotoxicity of (AFB1) among exposed workers.

MATERIAL AND METHODS: Liver enzymes, AFB1/Alb, and GST polymorphism were estimated in 132 wheat flour dust and 87 woods sawmill workers, and 156 controls.

RESULTS: Results revealed that AFB1/Alb and liver enzymes were significantly elevated in exposed workers compared to controls, and were significantly higher in sawmill workers compared to flour workers. AFB1/Alb in flour and sawmill workers with GSTT1 and GSTM1&GSTT1 null genotypes were significantly higher than controls, and in sawmill workers with GSTM1&GSTT1 null than flour workers. Liver enzymes (ALT and AST) in sawmill workers were significantly higher than flour workers and controls in all GST polymorphism; except in GSTT1 polymorphism, where these enzymes were significantly higher in the two exposed groups than controls.

CONCLUSIONS: In conclusion, organic dust exposure may cause elevation in AFB1/Alb and liver enzymes of exposed workers, and GST gene polymorphism plays an important role in susceptibility to hepatic parenchymal cell injury; except in workers with GSTT1&GSTM1 null genotype, gene susceptibility seemed to have little role and the main role was for environmental exposures.

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Published

2016-04-20

How to Cite

1.
Saad-Hussein A, Shahy EM, Shaheen W, Taha MM, Mahdy-Abdallah H, Ibrahim KS, Hafez SF, Fadl NN, El-Shamy KA. Comparative Hepatotoxicity of Aflatoxin B1 among Workers Exposed to Different Organic Dust with Emphasis on Polymorphism Role of Glutathione S-Transferase Gene. Open Access Maced J Med Sci [Internet]. 2016 Apr. 20 [cited 2022 Aug. 14];4(2):312-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2016.051

Issue

Section

E - Public Health

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