Madelung’s Disease – Case Series and Treatment by Tumescent Liposuction or Lipectomy
DOI:
https://doi.org/10.3889/oamjms.2017.114Keywords:
Lipomatosis, Madelung disease, adipose tissue, comorbidities, lipectomy, tumescent liposuctionAbstract
Madelung disease is a disfiguring disorder belonging to the heterogeneous group of lipomatosis. The aetiology is not well understood, but alcohol consumption has been regarded as of importance. The reported incidence is about 1 in 25,000 inhabitants. We reviewed our files of the last ten years and identified eight adult patients with an equal gender distribution. Their age was between 60 and 85 years of life. Comorbidities are frequent. Clinical presentation may vary. Surgical treatment is reported and discussed. Both cold steel surgery and tumescent liposuction have their place in treatment.Downloads
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González-GarcÃa R, RodrÃguez-Campo FJ, Sastre-Pérez J, Mu-oz-Guerra MF. Benign symmetric lipomatosis (Madelung's disease): case reports and current management. Aesthetic Plast Surg. 2004;28(2):108-12. https://doi.org/10.1007/s00266-004-3123-5 PMid:15164232
Brea-GarcÃa B, Cameselle-Teijeiro J, Couto-González I, Taboada-Suárez A, González-Ãlvarez E. Madelung's disease: comorbidities, fatty mass distribution, and response to treatment of 22 patients. Aesthetic Plast Surg. 201337(2):409-16. https://doi.org/10.1007/s00266-012-9874-5
Pinto CI, Carvalho PJ, Correia MM. Madelung's disease: Revision of 59 surgical Cases. Aesthetic Plast Surg. 2016.
Plummer C, Spring PJ, Marotta R, Chin J, Taylor G, Sharpe D, Athanasou NA, Thyagarajan D, Berkovic SF. Multiple symmetrical lipomatosis--a mitochondrial disorder of brown fat. Mitochondrion. 2013;13(4):269-76. https://doi.org/10.1016/j.mito.2013.03.003 PMid:23524250
Zancanaro C, Sbarbati A, Morroni M, Carraro R, Cigolini M, Enzi G, Cinti S. Multiple symmetric lipomatosis. Ultrastructural investigation of the tissue and preadipocytes in primary culture. Lab Invest. 1990;63(2):253-8. PMid:2381166
Enzi G, Busetto L, Sergi G, Coin A, Inelmen EM, Vindigni V, Bassetto F, Cinti S. Multiple symmetric lipomatosis: a rare disease and its possible links to brown adipose tissue. Nutr Metab Cardiovasc Dis. 2015;25(4):347-53. https://doi.org/10.1016/j.numecd.2015.01.010 PMid:25770761
Prantl L, Schreml J, Gehmert S, Klein S, Bai X, Zeitler K, Schreml S, Alt E, Gehmert S, Felthaus O. Transcription profile in sporadic multiple symmetric lipomatosis reveals differential expression at the level of adipose tissue-derived stem cells. Plast Reconstr Surg. 2016;137(4):1181-90. https://doi.org/10.1097/PRS.0000000000002013 PMid:27018673
Horev L, Lees MM, Anteby I, Gomori JM, Gunny R, Ben-Neriah Z. Oculoectodermal syndrome with coarctation of the aorta and moyamoya disease: expanding the phenotype to include vascular anomalies. Am J Med Genet A. 2011;155A(3):577-81. https://doi.org/10.1002/ajmg.a.33104 PMid:21337683
Tadisina KK, Mlynek KS, Hwang LK, Riazi H, Papay FA, Zins JE. Syndromic lipomatosis of the head and neck: a review of the literature. Aesthetic Plast Surg. 2015;39(3):440-8. https://doi.org/10.1007/s00266-015-0478-8 PMid:25860506
Sharma N, Hunter-Smith DJ, Rizzitelli A, Rozen WM. A surgical view on the treatment of Madelung's disease. Clin Obes. 2015;5(5):288-90. https://doi.org/10.1111/cob.12111 PMid:26246230
Brackenbury ET, Morgan WE. Surgical management of Launois-Bensaude syndrome. Thorax. 1997;52(9):834-5. PMid:9371221
Samdal F, Kleppe G, Tonvang G. Benign symmetric lipomatosis of the neck treated by liposuction. Case report. Scand J Plast Reconstr Surg Hand Surg. 1991;25(3):281-4. https://doi.org/10.3109/02844319109020633 PMid:1780727
Faga A, Valdatta LA, Thione A, Buoro M. Ultrasound assisted liposuction for the palliative treatment of Madelung's disease: a case report. Aesthetic Plast Surg. 2001;25(3):181-3. https://doi.org/10.1007/s002660010118 PMid:11426308
Hasegawa T, Matsukura T, Ikeda S. Mesotherapy for benign symmetric lipomatosis. Aesthetic Plast Surg. 2010;34(2):153-6. https://doi.org/10.1007/s00266-009-9374-4 PMid:19488808
Andou E, Komoto M, Hasegawa T, Mizuno H, Hayashi A. Surgical excision of Madelung disease using bilateral cervical lymphnode dissection technique-its effect and the influence of previous injection lipolysis. Plast Reconstr Surg Glob Open. 2015;3(4):e375. https://doi.org/10.1097/GOX.0000000000000337 PMid:25973353 PMCid:PMC4422206
Atiyeh B, Costagliola M, Illouz YG, Dibo S, Zgheib E, Rampillon F. Functional and therapeutic indications of liposuction: Personal experience and review of the literature. Ann Plast Surg. 2015;75(2):231-45. https://doi.org/10.1097/SAP.0000000000000055 PMid:25695452
Constantinidis J, Steinhart H, Zenk J, Gassner H, Iro H. Combined surgical lipectomy and liposuction in the treatment of benign symmetrical lipomatosis of the head and neck. Scand J Plast Reconstr Surg Hand Surg. 2003;37(2):90-6. https://doi.org/10.1080/02844310310005612 PMid:12755508
Tremp M, Wettstein R, Tchang LA, Schaefer DJ, Rieger UM, Kalbermatten DF. Power-assisted liposuction (PAL) of multiple symmetric lipomatosis (MSL)--a longitudinal study. Surg Obes Relat Dis. 2015;11(1):155-60.1997;52(9):834-5.
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