An Overview on Radiotherapy: From Its History to Its Current Applications in Dermatology


  • Serena Gianfaldoni University G. Marconi of Rome, Dermatology and Venereology, Rome 00192
  • Roberto Gianfaldoni University G. Marconi of Rome, Dermatology and Venereology, Rome 00192
  • Uwe Wollina Krankenhaus Dresden-Friedrichstadt, Department of Dermatology and Venereology, Dresden, Sachsen
  • Jacopo Lotti G. Marconi University, Department of Nuclear Physics, Subnuclear and Radiation, Rome
  • Georgi Tchernev Medical Institute of the Ministry of Interior, Dermatology, Venereology and Dermatologic Surgery; Onkoderma, Private Clinic for Dermatologic Surgery, Dermatology and Surgery, Sofia 1407
  • Torello Lotti Universitario di Ruolo, Dipartimento di Scienze Dermatologiche, Università degli Studi di Firenze, Facoltà di Medicina e Chirurgia, Dermatology, Via Vittoria Colonna 11, Rome 00186



radiotherapy, historical evolution, therapeutic option, cancers, cutaneous malignant diseases


For more than a century, radiotherapy has been an effective treatment for oncologic patients. The Authors report a brief history of the radiation therapy and its actual indication for the treatments of cutaneous malignant diseases.


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Jonathan D. Tward JD, Christopher J. Anker CJ et Al. Radiation Therapy and Skin Cancer. In Natanasabapathi G. Modern Practices in Radiation Therapy. InTech ed. 2012: 207-246.

Rontgen WC. Uber eine neue Art von Strahlen. Vorl¨ aufige Mitteilung. In: Sitzungsberichte¨ der physikalisch-medicinischen Gesellschaft zu W¨urzburg, Sitzung 1985. 30:132–141.

Grubbe EH. Priority in the therapeutic use of X-rays. Radiology´ 1933. 21: 156–162.

Becquerel AH, Curie P. Action physiologique des rayons de radium. Compt. Rend. Acad. Sci. 1901. 132, 1289–1291.

Lawrence EO, Livingston MS. The production of high speed light ions without the use of high voltages. Phys. Rev. 1932. 40:19–35.

Lederman M. The early history of radiotherapy: 1895–1939. Int. J. Radiat. Oncol. Biol. Phys. 1981. 7: 639–648.

Coutard H. Principles of X-ray therapy of malignant disease. Lancet 1934. 2:1–12.

Taylor, L. S. History of the International Commission on Radiological Protection (ICRP). Health Phys. 1958;1:97–104. PMid:13598297

Thoraeus, R. A. A study of ionization method for measuring the intensity and absorption of roentgen rays and of the efficiency of different filters used in therapy. Acta Radiol. 1932; 15: 1–86.

Courant ED. Early Milestones in the Evolution of Accelerators. In Chao AW. Reviews of Accelerator. Science and Technology vol. 1. Ed. World Scientific, Singapore, 2008: 1–5.

Boone MLM, Lawrence JH, Connor WG et al., Introduction to the use of protons and heavy ions in radiation therapy: historical perspective. Int. J. Radiat. Oncol. Biol. Phys. 1977;3:65–69.

Fry D W, Harvie RB, Mullett L et Al. A travelling-wave linear accelerator for 4-MeV electrons. Nature 1948;162:859–861. PMid:18103121

Suit H, Goitein M, Munzenrider J et al., Evaluation of the clinical applicability of proton beams in definitive fractionated radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 1982;8:2199–2205.

Hall EJ. The Physics and Chemistry of Radiation Absorption. In: Radiobiology for the radiologists. 4th edition. Philadelphia: JB Lippincott, 1994:8-10.

Ying CH. Update of Radiotherapy for Skin Cancer. Hong Kong Dermatology & Venereology Bulletin.2001; 9(2): 52-59.

Mohan, R. Field shaping for three-dimensional conformal radiation therapy and multileaf collimation. Semin. Radiat. Oncol. 1995;5: 86–99.

Milano MT, Katz AW, Zhang H et Al. Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study. Int. J. Radiat. Oncol. Biol. Phys. 2012; 83: 878–886. PMid:22172903

Schwartz DL et al. Adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial. Int. J. Radiat. Oncol. Biol. Phys. 2012; 83: 986–993. PMid:22138459 PMCid:PMC4271827

Veness M, Richards S. Radiotherapy. In: Bolognia J, Jorizzo J, and Schaffer J, eds. Dermatology, vol. 2. Philadelphia: WB Sauders; 2012: 2291–2301.

Ying CH. Update of Radiotherapy for Skin Cancer. Hong Kong Dermatology & Venereology Bulletin. 2001; 9(2): 52-58.

Cognetta A, Howard B, Heaton H, et. Al. Superficial X-ray in the treatment of basal and squamous cell carcinoma: a viable option in select patients. J Am Acad Dermatol. 2012;67:1237–1241. PMid:22818756

Petit JY, Avril MF, Margulis A, et. al. Evaluation of cosmetic results of a randomized trial comparing surgery and radiotherapy in the treatment of basal cell carcinoma of the face. Plast Reconstr Surg. 2000;105:2544–2551. PMid:10845311

Zagrodnik B, Kempf W, Seifert E, et. al. Superficial radiotherapy for patients with basal cell carcinoma. Cancer. 2003;98(12):2708–2714. PMid:14669293

Wolstenholme V, Glees JP. The Role of Kilovoltage X-rays in the Treatment of Skin Cancers. European Oncological Disease, 2006;1(1):32-5.

Barysch M, Eggman N, Beyeler M, et. al. Long term recurrence rate of large and difficult to treat cutaneous squamous cell carcinomas after superficial radiotherapy. Dermatology. 2012;224:59–65. PMid:22433440

Gillenwater AM, et Al. Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival. Arch Otolaryngol Head Neck Surg, 2001; 127(2):149-54. PMid:11177031

Jabbour J. et Al. Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004. Ann Surg Oncol, 2007;14(6): 1943-52. PMid:17356954

Micaily B. et Al. Radiotherapy for unilesional mycosis fungoides. Int J Radiat Oncol Biol Phys.1998;42(2): 361-4.

Cooper JS. The influence of dose on the long-term control of classic (non-AIDS associated) Kaposi's Sarcoma by radiotherapy. Int J Radiat Oncol Biol Phys. 1988;15:1141-6.

Farshad, A., et al., A retrospective study of 150 patients with lentigo maligna and lentigo maligna melanoma and the efficacy of radiotherapy using Grenz or soft X-rays. Br J Dermatol. 2002;146(6):1042-6. PMid:12072074

Chen, J.C., et al., Stereotactic radiosurgery in the treatment of metastatic disease to the brain. Neurosurgery. 2000; 47(2): 268-79. PMid:10942000

Kamada, T. Clinical evidence of particle beam therapy (carbon). Int. J. Clin. Oncol. 2012;17: 85–88. PMid:22426888



How to Cite

Gianfaldoni S, Gianfaldoni R, Wollina U, Lotti J, Tchernev G, Lotti T. An Overview on Radiotherapy: From Its History to Its Current Applications in Dermatology. Open Access Maced J Med Sci [Internet]. 2017 Jul. 18 [cited 2023 Feb. 4];5(4):521-5. Available from:

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