Chimeric Monoclonal Antibody Cetuximab Targeting Epidermal Growth Factor-Receptor in Advanced Non-Melanoma Skin Cancer

Authors

  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, 01067 Dresden
  • Georgi Tchernev Medical Institute of the Ministry of Interior, Dermatology, Venereology and Dermatologic Surgery; Onkoderma, Private Clinic for Dermatologic Surgery, Dermatology and Surgery, Sofia 1407
  • Torello Lotti University G. Marconi of Rome, Dermatology and Venereology, Rome 00192

DOI:

https://doi.org/10.3889/oamjms.2018.022

Keywords:

cetuximab, epidermal growth factor receptor, non-melanoma skin cancer, targeted treatment, skin toxicities

Abstract

BACKGROUND: Non-melanoma skin cancer (NMSC) is the most common malignancy in humans. Targeted therapy with monoclonal antibody cetuximab is an option in case of advanced tumor or metastasis.

AIM: We present and update of the use of cetuximab in NMSC searching PUBMED 2011-2017.

METHODS: The monoclonal antibody cetuximab against epidermal growth factor receptor (EGFR) has been investigated for its use in NMSC during the years 2011 to 2017 by a PUBMED research using the following items: “Non-melanoma skin cancer AND cetuximab,†“cutaneous squamous cell carcinoma AND cetuximab,†and “basal cell carcinoma AND cetuximabâ€, and “cetuximab AND skin toxicityâ€. Available data were analyzed including case reports.

RESULTS: Current evidence of cetuximab efficacy in NMSC was mainly obtained in cutaneous SCC and to a lesser extend in BCC. Response rates vary for neoadjuvant, adjuvant, mono- and combined therapy with cetuximab. Management of cutaneous toxicities is necessary. Guidelines are available.

CONCLUSIONS: Cetuximab is an option for recurrent or advanced NMSC of the skin. It seems to be justified particularly in very high-risk tumors. There is a need for phase III trials.

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Published

2017-12-31

How to Cite

1.
Wollina U, Tchernev G, Lotti T. Chimeric Monoclonal Antibody Cetuximab Targeting Epidermal Growth Factor-Receptor in Advanced Non-Melanoma Skin Cancer. Open Access Maced J Med Sci [Internet]. 2017 Dec. 31 [cited 2021 Apr. 12];6(1):152-5. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.022

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