Schizophrenia as Potential Trigger for Melanoma Development and Progression! The Psycho-Neuro-Endocrine-Oncology (P.N.E.O) Network!
Keywords:Malignant melanoma, Antipsychotics, Levodopa, Advancing
BACKGROUND: Skin, nervous tissue, dopamine and melanoma share a common neuroectodermal origin. Hence, processes that modulate nervous tissue formation, patient mental status, motor regulation of individuals, and skin cancerogenesis are inextricably linked. Psycho-neuro-endocrine oncology (or dermato-oncology), i.e. P.N.E.O., is a new model or trend in medicine and science presented for the first time in the world literature by us, that aims to examine the relationship between the mental state, the hormones and the malignant transformation. Schizophrenia and Parkinsonâ€™s disease are the two main patterns of disease where the main symptoms are related to dopamine levels in the human body. According to our analyses of the available literature, the amount of dopamine is related to the incidence of melanocytic or non-melanocytic cutaneous tumours in patients with central nervous system diseases and those affecting the motor function and coordination. Such patterns of interaction are extremely indicative of the elucidation of the ubiquitous hypothesis or statement: â€œMy illness is on a mental basis, caused by stress ...â€
CASE PRESENTATION: We present a 44-year-old patient with untreated schizophrenia for approximately 25 years, associated with advanced acral localised melanoma. Schizophrenia is generally associated with a higher level of dopamine, which is also a key precursor to melanin synthesis. After a careful analysis of all literature on melanoma in patients with 1) treated and untreated schizophrenia, 2) those with untreated and untreated forms of Parkinsonâ€™s disease, it would be logical to conclude that the high level of dopamine in the described patient groups is a risk factor for the development of melanoma.CONCLUSIONS: The possible mechanisms for the occurrence of malignant melanoma within the so-called psycho/neuro/endocrine oncology (P.N.E.O.), as well as the effective methods of prevention, are under discussion.
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Millier A, Schmidt U, Angermeyer M, Chauhan D, Murthy V, Toumi M, Cadi-Soussi N. Humanistic burden in schizophrenia: a literature review. J Psychiatr Res. 2014; 54:85-93. https://doi.org/10.1016/j.jpsychires.2014.03.021 PMid:24795289
Werner F, Cove-as R. Safety of antipsychotic drugs: focus on therapeutic and adverse effects. Expert Opin Drug Saf. 2014; 13(8):1031-42. https://doi.org/10.1517/14740338.2014.935761 PMid:24975932
Krummel T, Neifeld JP, Taub N. Effects of dopamine agonists and antagonists on murine melanoma: correlation with dopamine binding activity. Cancer. 1982; 49(6):1178-84. https://doi.org/10.1002/1097-0142(19820315)49:6<1178::AID-CNCR2820490619>3.0.CO;2-H
Bertoni J, Arlette P, Fernandez H, Fitzer-Attas C, Frei K, Hassan N, Isaacson H, Lew F, Molho E, Ondo G, Phillips J, Singer C, Sutton P, Wolf J. Increased melanoma risk in Parkinson disease: a prospective clinicopathological study. Arch Neurol. 2010; 67(3):347-52. https://doi.org/10.1001/archneurol.2010.1 PMid:20212233
Inzelberg R, Rabey JM, Melamed E, Djaldetti R, Reches A, Badarny S, Hassin-Baer S, Cohen O, Trau H, Aharon-Peretz J, Milo R, Schwartz M, Huberman M, Gilead L, Barchana M, Liphshiz I, Fitzer-Attas C, Giladi N. High prevalence of malignant melanoma in Israeli patients with Parkinson's disease. J Neural Transm (Vienna). 2011; 118(8):1199-207. https://doi.org/10.1007/s00702-011-0580-2 PMid:21298300
Mortensen P. The occurrence of cancer in first admitted schizophrenic patients. Schizophr Res. 1994; 12(3):185-94. https://doi.org/10.1016/0920-9964(94)90028-0
Craig S, Earnshaw C, VirÃ³s A. Ultraviolet light and melanoma. J Pathol. 2018; 244(5):578-585. https://doi.org/10.1002/path.5039 PMid:29380860
Tchernev G, Orfanos CE. Downregulation of cell cycle modulators p21, p27, p53, Rb and proapoptotic Bcl-2-related proteins Bax and Bak in cutaneous melanoma is associated with worse patient prognosis: preliminary findings. J Cutan Pathol. 2007; 34(3):247-56. https://doi.org/10.1111/j.1600-0560.2006.00700.x PMid:17302609
Fecker LF, Geilen CC, Tchernev G, Trefzer U, Assaf C, Kurbanov BM, Schwarz C, Daniel PT, Eberle J. Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis. J Invest Dermatol. 2006; 126(6):1366-71. https://doi.org/10.1038/sj.jid.5700192 PMid:16528364
Hendi A, Brodland D, Zitelli J. Melanocytes in long-standing sun-exposed skin: quantitative analysis using the MART-1 immunostain. Arch Dermatol. 2006; 142(7):871-6. https://doi.org/10.1001/archderm.142.7.871 PMid:16847203
Watson M, Holman D, Maguire-Eisen M. Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk. Semin Oncol Nurs. 2016; 32(3):241â€“254. https://doi.org/10.1016/j.soncn.2016.05.005 PMid:27539279 PMCid:PMC5036351
Herrero HernÃ¡ndez E. Pigmentation genes link Parkinson's disease to melanoma, opening a window on both etiologies. Med Hypotheses. 2009; 72(3):280-4. https://doi.org/10.1016/j.mehy.2008.10.011 PMid:19027242
Pho N, Leachman A. Genetics of pigmentation and melanoma predisposition. G Ital Dermatol Venereol. 2010; 145(1):37-45. PMid:20197744
Potrony M, Badenas C, Aguilera P, Puig-Butille J, Carrera C, Malvehy J. Update in genetic susceptibility in melanoma. Ann Transl Med. 2015; 3(15): 210. PMid:26488006 PMCid:PMC4583600
Fiala K, Whetteckey J, Manyam V. Malignant melanoma and levodopa in Parkinson's disease: causality or coincidence? Parkinsonism Relat Disord. 2003; 9(6):321-7. https://doi.org/10.1016/S1353-8020(03)00040-3
Disse M, Reich H, Lee P, Schram S. A Review of the Association Between Parkinson Disease and Malignant Melanoma. Dermatol Surg. 2016; 42(2):141-6. https://doi.org/10.1097/DSS.0000000000000591 PMid:26771684
Perez-Lloret S, Rascol O. Dopamine receptor agonists for the treatment of early or advanced Parkinson's disease. CNS Drugs. 2010; 24(11):941-68. https://doi.org/10.2165/11537810-000000000-00000 PMid:20932066
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