Acrocyanosis – A Symptom with Many Facettes


  • Uwe Wollina Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • André Koch Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Dana Langner Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Gesina Hansel Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Birgit Heinig Städtisches Klinikum Dresden - Center of Physical and Rehabilitative Medicine, Dresden
  • Torello Lotti University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, Sofia; Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, Sofia



Acrocyanosis, hands and feet, vascular disorders, Raynaud syndrome, Connective tissue diseases, Adverse drug reactions, Tumors


Acrocyanosis is an uncommon complaint belonging to the acro-syndromes. It typically presents with coolness and bluish discolourations of hands, feet, ears, nose, lips and nipple. The most frequently affected parts of the body are the hands. This review discusses physical factors, vascular disorders, infectious diseases, haematological disorders, solid tumours genetic disorders, drugs, eating disorders, and spinal disease presenting as or leading to acrocyanosis.


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How to Cite

Wollina U, Koch A, Langner D, Hansel G, Heinig B, Lotti T, Tchernev G. Acrocyanosis – A Symptom with Many Facettes. Open Access Maced J Med Sci [Internet]. 2018 Jan. 10 [cited 2024 Jun. 15];6(1):208-12. Available from:

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