Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma

Farhat Farhat; Elvita Rahmi Daulay; Jessy Chrestella; Rizalina Arwinati Asnir; Ashri Yudhistira; Riko Radityatama Susilo

doi:10.3889/oamjms.2018.355

Authors

Farhat Farhat Universitas Sumatera Utara Fakultas Kedokteran, Otorhynolaryngology Head and Neck Surgery Jl. Dr. T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia
Elvita Rahmi Daulay Universitas Sumatera Utara Fakultas Kedokteran, Radiology Medan, North Sumatera, Indonesia
Jessy Chrestella Universitas Sumatera Utara Fakultas Kedokteran, Pathology Medan, Sumatera Utara, Indonesia
Rizalina Arwinati Asnir Universitas Sumatera Utara Fakultas Kedokteran, Otorhynolaryngology Head and Neck Surgery Jl. Dr. T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia
Ashri Yudhistira Universitas Sumatera Utara Fakultas Kedokteran, Otorhynolaryngology Head and Neck Surgery Jl. Dr. T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia
Riko Radityatama Susilo Universitas Sumatera Utara Fakultas Kedokteran, Otorhynolaryngology Head and Neck Surgery Jl. Dr. T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2018.355

Keywords:

p38 MAPK, Nasopharyngeal carcinoma, Clinical stage, Correlation, Biomarker

Abstract

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma.

AIM: The aim of this study is for observing and analysing the correlation of p38 mitogen-activated protein kinase expression in regards to nasopharyngeal carcinoma patientâ€™s clinical stage.

METHODS: This study involved 126 nasopharyngeal carcinoma patients admitted to Haji Adam Malik General Hospital.

RESULTS: The result of this study indicates that nasopharyngeal carcinoma mostly found in the age group 41-60 years, male, non-keratinizing squamous cell carcinoma, and stage IV group. In immunohistochemistry evaluation, most of p38 mitogen-activated protein kinase overexpressed in non-keratinizing squamous cell carcinoma, T3-T4, N2-N3 and clinical stage III-IV. Spearmanâ€™s test for categorical correlation yield p-value of < 0.001.

CONCLUSION: In conclusion, there is a significant correlation between p38 mitogen-activated protein kinase expression and the clinical stage of nasopharyngeal carcinoma.

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