Prognostic Factors of Local-Regional Recurrence in Patients with Operable Breast Cancer in Asia: A Meta-Analysis

Prognostic factors for local regional recurrence in operable breast cancer patients in Asia

Authors

  • Wirsma Arif Harahap Surgical Oncology Division, Faculty of Medicine, Universitas Andalas, Dr M Djamil, General Hospital Padang, West Sumatera Province, Indonesia
  • Ricvan Dana Nindrea Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Andalas, Padang City, Indonesia https://orcid.org/0000-0002-1844-3323

DOI:

https://doi.org/10.3889/oamjms.2019.151

Keywords:

Prognostic factors, Recurrence, Operable breast cancer, Asian Population

Abstract

BACKGROUND: Cause of recurrence of breast cancer is multifactorial. Also, the occurrence of breast cancer in Asian patients has some different factors from the recurrence of breast cancer in western countries.

AIM: This study aims to determine the prognostic factors of local-regional recurrence in patients with operable breast cancer in Asia.

METHODS: The authors conducted a meta-analysis of published research articles published in an online database of PubMed, ProQuest and EBSCO between January 2000 and July 2018. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed by using Review Manager 5.3 (RevMan 5.3).

RESULTS: This study reviewed 879 articles. There were 11 studies conducted a systematic review then continued by meta-analysis of relevant data with total patients involved were 5,213 patients. The prognostic factors found of local-regional recurrence in patients with operable breast cancer were Nodal (N) stage with the highest risk ratio (RR = 6.35 [95% CI 3.78-10.67]) followed by HER2 positive (RR = 2.14 [95% CI 1.16-3.97]), stage of cancer (RR = 1.82 [95% CI 1.44-2.31]), tumor size (RR = 1.55 [95% CI 1.04-2.31]), tumor grade (RR = 1.43 [95% CI 1.23-1.65]), PR status (RR = 0.65 [95% CI 0.48-0.88]) and the least was ER status (RR = 0.60 [95% CI 0.39-0.91]). Homogeneity of variance was found in N stage, tumor size and tumor grade for recurrence of operable breast cancer.

CONCLUSION: This meta-analysis confirmed the correlation of N stage, HER2, stage of cancer, tumour size, tumour grade, ER and PR status with recurrence in patients with operable breast cancer in Asia.

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Published

2019-02-27

How to Cite

1.
Harahap WA, Nindrea RD. Prognostic Factors of Local-Regional Recurrence in Patients with Operable Breast Cancer in Asia: A Meta-Analysis: Prognostic factors for local regional recurrence in operable breast cancer patients in Asia. Open Access Maced J Med Sci [Internet]. 2019 Feb. 27 [cited 2024 Mar. 29];7(4):690-5. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.151

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Section

F - Review Articles

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