The Potency of Hibiscus rosa-sinensis Linn. Leaves Ethanol Extract as Hair Growth

Imam Budi Putra; Nelva K Jusuf; Imam Bagus Sumantri

doi:10.3889/oamjms.2020.4211

Authors

Imam Budi Putra Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Nelva K Jusuf Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Imam Bagus Sumantri Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2020.4211

Keywords:

Hibiscus rosasinensis leaf extract, Hair Growth

Abstract

INTRODUCTION: Hair is one of the organs and crowns for all people. Hair loss will really bother for most people. One of the plants that can be used as hair growth is Hibiscus rosa-sinensis Linn.

OBJECTIVE: The objective of the study was to find the potency of H. rosa-sinensis leaves ethanol extracts as hair growth.

METHODS: In this research, simplicia and extracts were made from hibiscus leaves using ethanol as a solvent. Simplicia and extracts were tested for phytochemical screening and characterization of each. The extract obtained was tested in vivo with animals test by observing mouseâ€™s hair growth for 25 days of observation.

RESULTS: Simplicia and ethanol extract of Hibiscus leaves contain flavonoids, alkaloids, glycosides, tannins, and steroids/terpenoids. The characteristics of Hibiscus leaves simplicia and extract had water content (9.71% vs. 10.65%), water-soluble extract content (19.91% vs. 27.58%), ethanol-soluble extract content (37.86% vs. 49.51%), total ash content (7.96% vs. 9.46%), and acid-insoluble ash content (0.78% vs. 1.28%). In vivo testing with animals, ethanol extract of Hibiscus leaves had an effect as a hair growth until the 25^thday with an average concentration of 2.5% (14 mm), 5% (16 mm), and 10% (19 mm).

DISCUSSION: The extract of Hibiscus leaves that showed the presence of carbohydrate, alkaloid, flavonoid, steroids, protein, tannin, and amino acids. The presence of active constituents such as flavonoids and tannins may be responsible for hair growth activity.

CONCLUSION: The ethanol extracts of H. rosa-sinensis leaves can increase hair growth, at optimum concentrations of 10% extract.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Apriyani D, Marwiyah D. The effect of pineapple (Ananas comosus) on dandruff in beauty student. J Beauty Beauty Health Educ. 2014;3(1):1-8.

Rassman WR, Pak JP, Schweiger E, Bernstein RM. Hair Loss and Replacement for Dummies. Indianapolis: Wiley Publishing Inc.; 2009.

Horev L. Environmental and cosmetic factors in hair loss and destruction. Curr Probl Dermatol. 2007;35:103-17. PMid:17641493

Nurjanah N, Krisnawati M. The effect of Sansevieria trifasciata Prain hair tonic and celery (Apium graveolens Linn) in managing hairloss. J Beauty Beauty Health Educ. 2014;3(1):1-8.

Estri SA. Treatment option of alopecia areata. Mutiara Med. 2008;8(2):73-82.

Rajput R. Role of non androgenic factors in hair loss and hair regrowth. Int J Clin Expl Dermatol. 2016;1(1):1-11. https://doi. org/10.4172/2471-9323.1000118

Swee W, Klontz KC, Lambert LA. A nationwide outbreak of alopecia associated with the use of a hair-relaxing formulation. Arch Dermatol. 2000;136(9):1104-8. https://doi.org/10.1001/ archderm.136.9.1104 PMid:10987865

Umborowati MA. Environment and cosmetic induced hair loss. Berkala Ilmu Kesehatan Kulit Kelamin. 2012;24(1):35-42.

Shapiro J. Drug induced alopecia. In: Shapiro J, editor. Hair Loss Principles of Diagnosis and Management of Alopecia. London: Martin Dunitz; 2002. p. 135-46. https://doi. org/10.4324/9780203428528

Soepardiman L, Rambut K. In: Djuanda A, Hamzah M, Aisah S, editors. Ilmu Penyakit Kulit dan Kelamin. Jakarta: Badan Penerbit Fakultas Kedokteran Universitas Indonesia; 2010. p. 301-11.

Fabbrocini G, Cantelli M, MasarÃ A, Annunziata MC, Marasca C, Cacciapuoti S. Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review. Int J Womens Dermatol. 2018;4(4):203-11. https://doi.org/10.1016/j. ijwd.2018.05.001 PMid:30627618

Adhirajan N, Ravi Kumar T, Shanmugasundaram N, Babu M. In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. J Ethnopharmacol. 2003;88(2-3):235-9. https://doi.org/10.1016/s0378-8741(03)00231-9 PMid:12963149

Upadhyay SM, Upadhyay P, Ghosh AK, Singh V, Dixit VK. Effect of ethanolic extract of Hibiscus rosa-sinensis L. flowers on hair growth in female Wistar rats. Pharm Lett. 2011;3(4):258-63.

Singh N, Tailang M, Pathak AK. Evaluation of hair growth activity of Hibiscus rosa-sinensis and Calotropis gigantea leaves on stress induced alopecia. World J Pharm Res. 2017;6(17):477-84.

Rahmawati D, Djamil R, Rahmat D. Hair tonic combination product from daun bunga sepatu (Hibiscus rosa-sinensis, L.) and biji saga (Abrus precatorius, L.) for hair growth. Human. 2017;10(4):222-32.