The Correlation between the Indonesian Version of Montreal Cognitive Assessment and Homocysteine Levels in Bataknese Male with Schizophrenia in Prof. DR. M. Ildrem Psychiatric Hospital Medan

Authors

  • Yoseva Hotnauli Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-7763-5528
  • Bahagia Loebis Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Muhammad Surya Husada Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0001-6214-2838
  • Nazli Mahdinasari Nasution Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Elmeida Effendy Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6364

Keywords:

Schizophrenia, Homocysteine, MoCA-INA, Bataknese

Abstract

BACKGROUND: The pathogenesis of schizophrenia and its mechanism is not convinced. Several studies indicate that schizophrenia pathogenesis can be related to changes at the cellular level. The studies show homocysteine in people with schizophrenia was significantly increased, abnormal homocysteine metabolism can lead to DNA methylation.

AIM: This study aimed to establish the correlation between the Indonesian Montreal Cognitive Assessment Version (MoCA-Ina) scores and homocysteine levels in males with Bataknese schizophrenia.

METHODS: This study is a numerical correlative analytic study with an approach to cross-sectional study; by evaluating the correlation between the MoCA-Ina scores and the level of homocysteine in males with Bataknese schizophrenia.

RESULTS: The median of the MoCA-Ina score in the study subjects was 22, with a minimum score of 18 and a maximum score of 26. There was a significant correlation between the MoCA-Ina scores and Homocysteine levels (p = 0.001).

CONCLUSION: The interpretation obtained from this study is that the higher Homocysteine level, the lower the MoCA-Ina scores in Bataknese men with schizophrenia is.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Jing D, Mao X, Zhi L, Xinyuan L. Cognitive ability and the level of serum homocysteine correlations in first-episode schizophrenia subjects. J Psychiatry Brain Sci. 2018;3(2):1-6. https://doi.org/10.20900/jpbs.20180003 DOI: https://doi.org/10.20900/jpbs.20180003

Zahnia S, Sumekar DW. Epidemiological study of schizophrenia. Majority. 2016;5(4):160-6.

Moustafa AA, Hewed DH, Eissa AM, Frydecka D, Misiak B. Homocysteine levels in schizophrenia and affective disorders-focus on cognition. Front Behav Neurosci. 2014;8(343):1-10. https://doi.org/10.3389/fnbeh.2015.00081 PMid:25339876 DOI: https://doi.org/10.3389/fnbeh.2014.00343

Milller AL. The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev. 2003;8(1):7-19. PMid:12611557

Teunissen CE, van Boxtel MP, Jolles J, Vente JD, Vreeling F, Verhey F, et al. Homocysteine in relation to cognitive performance in pathological and non-pathological conditions. Clin Chem Lab Med. 2005;43(10):1089-95. https://doi.org/10.1515/cclm.2005.190 PMid:16197303 DOI: https://doi.org/10.1515/CCLM.2005.190

Sadock BJ, Sadock V, Ruiz P. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry. 10th ed., Vol. 1, 2. New York: Wolters Kluwer; 2017. p. 2751. https://doi.org/10.4067/s0717-92272002000300011 DOI: https://doi.org/10.4067/S0717-92272002000300011

Levine J, Stahl Z, Sela BA, Gavendo S, Ruderman V, Belmaker RH. Elevated homocysteine levels in young male patients with schizophrenia. Am J Psychiatry. 2002;159(10):1790-2. https://doi.org/10.1176/appi.ajp.159.10.1790 PMid:12359692 DOI: https://doi.org/10.1176/appi.ajp.159.10.1790

Yang B, Fan S, Zhi X, Wang Y, Wang Y, Zheng Q, et al. Prevalence of hyperhomocysteinemia in China: A systematic review and meta-analysis. Nutrients. 2015;7(1):74-90. https://doi.org/10.3390/nu7010074 PMid:25551247 DOI: https://doi.org/10.3390/nu7010074

Mabrouka H, Doukia W, Mechrib A, Younesa MK, Omezzinec A, Bouslamac A, et al. Hyperhomocysteinemia and schizophrenia: Case control study. Lencephale. 2011;37(4):308-13. PMid:21981892

Di Lorenzo R, Amoretti A, Baldini S, Soli M, Landi G, Pollutri G, et al. Homocysteine level in schizophrenia patients newly admitted to an acute psychiatric ward. Acta Neuropsychiatrica. 2015;27(6):336-44. https://doi.org/10.1017/neu.2015.30 PMid:26017629 DOI: https://doi.org/10.1017/neu.2015.30

Narayan SK, Verman A, Kattimani S, Ananthanarayanan PH, Adithan C. Plasma homocysteine levels in depression and schizophrenia in South Indian Tamilian population. Indian J Psychiatry. 2014;56(1):46-53. https://doi.org/10.4103/0019-5545.124746 PMid:24574558 DOI: https://doi.org/10.4103/0019-5545.124746

Ma YY, Shek CC, Wong MC, Yip KC, Ng RM, Nguyen DG, et al. Homocysteine level in schizophrenia patients. Aust N Z J Psychiatry. 2009;43(8):760-5. PMid:19629798 DOI: https://doi.org/10.1080/00048670903001935

Downloads

Published

2021-06-13

How to Cite

1.
Hotnauli Y, Loebis B, Husada MS, Nasution NM, Effendy E. The Correlation between the Indonesian Version of Montreal Cognitive Assessment and Homocysteine Levels in Bataknese Male with Schizophrenia in Prof. DR. M. Ildrem Psychiatric Hospital Medan. Open Access Maced J Med Sci [Internet]. 2021 Jun. 13 [cited 2024 Jul. 21];9(T3):135-7. Available from: https://oamjms.eu/index.php/mjms/article/view/6364

Most read articles by the same author(s)

<< < 1 2 3 4 5 6 7 8 9 > >>