Anti-Inflammatory Potency of Mangosteen (Garcinia mangostana L.): A Systematic Review


  • Andreas Arie Setiawan Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
  • Jethro Budiman Department of Anatomic Pathology, Faculty of Medicine, Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia; Emergency Unit, Panti Wilasa Citarum Hospital, Semarang, Indonesia
  • Awal Prasetyo Department of Anatomic Pathology, Faculty of Medicine, Diponegoro University, Dr. Kariadi Hospital, Semarang, Indonesia; Department of Biomedical Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia



Anti-inflammatory, Garcinia mangostana L., Mangosteen


BACKGROUND: Mangosteen (Garcinia mangostana L.) is a tropical fruit, widely used in Southeast Asia as a health food and supplement, because of its beneficial effects on the body. In many studies, mangosteen is described to have many health effects such as antimicrobial, antioxidant, anti-proliferative, anti-carcinogenic, and antiinflammatory. The anti-inflammatory effect is important because many diseases have pathophysiology associated with the inflammatory process.

AIM: This study aimed to assess and conclude the scientific database systematically to investigate the anti-inflammatory potency of mangosteen (Garcinia mangostana L.).

METHODS: Cochrane handbook for systematic reviews and the guideline of preferred reporting items for systematic review and meta-analysis (PRISMA) were used as guidelines in this review.

RESULTS: The authors searched the study in electronic databases which met inclusion and exclusion criteria. The authors independently evaluated 412 studies in database finding, 24 studies fulfilled the criteria for this review.

CONCLUSION: Mangosteen (Garcinia mangostana L.) has anti-inflammatory potency (especially the component of xanthone and flavonoid) in various inflammatory conditions and diseases; such as obesity, skin disease, psychiatric disease, tooth disease, asthma, atherosclerosis, acetaminophen-induced hepatotoxicity, peritonitis, colitis, prostatic hyperplastic, arthritis, and soft-tissue inflammation.


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How to Cite

Setiawan AA, Budiman J, Prasetyo A. Anti-Inflammatory Potency of Mangosteen (Garcinia mangostana L.): A Systematic Review. Open Access Maced J Med Sci [Internet]. 2023 Jan. 2 [cited 2023 Dec. 6];11(F):58-66. Available from:



Systematic Review Article