O Blood Group as Risk Factor for Preeclampsia among Sudanese Women

Authors

  • Abdelmageed Elmugabil Faculty of Medicine, El Imam El Mahdi University, Kosti
  • Duria A. Rayis Faculty of Medicine, University of Khartoum, Khartoum
  • Mohamed A. Ahmed Faculty of Medicine, University of Khartoum, Khartoum
  • Ishag Adam Faculty of Medicine, University of Khartoum, Khartoum
  • Gasim I. Gasim Faculty of Medicine and Health Sciences, Alneelain University, Khartoum

DOI:

https://doi.org/10.3889/oamjms.2016.108

Keywords:

Preeclampsia, blood groups, Sudan, pregnancy

Abstract

AIM: To investigate blood groups and the other possible risk factors for preeclampsia among Sudanese women.

MATERIAL AND METHODS: A case – control study was conducted at Saad Abualila Hospital, Khartoum, Sudan during the period of July 2013 through December 2014. The cases were women with preeclampsia and healthy pregnant women were the controls.

RESULTS: Two hundred eighty pregnant women were enrolled (140 in each arm of the study). Around one-quarter of all women (280) were primiparae (74.0, 26.4%), the majority were housewives (201, 71.7%). Seventy-nine (28.2%) were illiterate or had no informal education. Around half of the women (130, 46.4%) had O blood group. Binary logistic regression showed association between preeclampsia and lack of antenatal care (OR = 2.75, 95% CI = 1.172─6.494, P = 0.020) as well as O blood group (OR = 1.78, 95% CI = 1.088─2.934, P=0.022).

CONCLUSION: The current study showed that women with blood group O were at higher risk of preeclampsia.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

Author Biography

Ishag Adam, Faculty of Medicine, University of Khartoum, Khartoum

Faculty of Medicine, Univeristy of Khartoum

References

Robillard P-Y, Hulsey TC, Dekker GA, Chaouat G. Preeclampsia and human reproduction. An essay of a long term reflection. J Reprod Immunol. 2003; 59(2):93–100. http://dx.doi.org/10.1016/S0165-0378(03)00040-8

Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33(3):130–7. http://dx.doi.org/10.1053/j.semperi.2009.02.010 PMid:19464502

Conde-Agudelo A, Belizan JM. Risk factors for pre-eclampsia in a large cohort of Latin American and Caribbean women. BJOG. 2000;107(1):75–83. http://dx.doi.org/10.1111/j.1471-0528.2000.tb11582.x PMid:10645865

Lee C-J, Hsieh T-T, Chiu T-H, Chen K-C, Lo L-M, Hung T-H. Risk factors for pre-eclampsia in an Asian population. Int J Gynecol Obstet. 2000;70(3):327–33. http://dx.doi.org/10.1016/S0020-7292(00)00240-X

Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI Working Group on research on hypertension during pregnancy. Hypertension. 2003;41(3 I):437–45.

Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365(9461):785–99. http://dx.doi.org/10.1016/S0140-6736(05)71003-5

Adeyinka DA, Oladimeji O, Adekanbi TI, Adeyinka FE, Falope Y, Aimakhu C. Outcome of adolescent pregnancies in southwestern Nigeria: a case-control study. J Matern Fetal Neonatal Med. 2010; 23(8):785–9. http://dx.doi.org/10.3109/14767050903572166 PMid:20082596

Ali AA, Rayis DA, Abdallah TM, Elbashir MI, Adam I. Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan. BMC Res Notes. 2011;4(1):311. http://dx.doi.org/10.1186/1756-0500-4-311 PMid:21867566 PMCid:PMC3224576

Ndayambagye EB, Nakalembe M, Kaye DK. Factors associated with persistent hypertension after puerperium among women with pre-eclampsia/eclampsia in Mulago hospital, Uganda. BMC Pregnancy Childbirth. 2010;10:12. http://dx.doi.org/10.1186/1471-2393-10-12 PMid:20222993 PMCid:PMC2848130

Franchini M, Mengoli C, Lippi G. Relationship between ABO blood group and pregnancy complications: a systematic literature analysis. Blood Transfus. 2016;1–8. PMid:27483484

Witsenburg CPJ, Rosendaal FR, Middeldorp JM, Van Der Meer FJM, Scherjon SA. Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation. Thromb Res. 2005;115(5):387–92. http://dx.doi.org/10.1016/j.thromres.2004.09.009 PMid:15733972

Clark P, Walker ID, Govan L, Wu O, Greer IA. The GOAL study: A prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol. 2008;140(2):236–40. PMid:18028481

Hiltunen LM, Laivuori H, Rautanen A, Kaaja R, Kere J, Krusius T, et al. Blood group AB and factor V Leiden as risk factors for pre-eclampsia: A population-based nested case-control study. Thromb Res. 2009;124(2):167–73. http://dx.doi.org/10.1016/j.thromres.2008.11.012 PMid:19110300

Lee BK, Zhang Z, Wikman A, Lindqvist PG, Reilly M. ABO and RhD blood groups and gestational hypertensive disorders: a population-based cohort study. BJOG. 2012 Sep;119(10):1232–7. http://dx.doi.org/10.1111/j.1471-0528.2012.03421.x PMid:22734590

Phaloprakarn C, Tangjitgamol S. Maternal ABO blood group and adverse pregnancy outcomes. J Perinatol. 2013;33(2):107–11. http://dx.doi.org/10.1038/jp.2012.73 PMid:22678143

Leiberman JR, Fraser D, Kasis A, Mazor M. Reduced frequency of hypertensive disorders in placenta previa. Obstet. Gynecol. 1991;77:83–86. PMid:1984232

Ali AA, Adam I. Lack of antenatal care, education, and high maternal mortality in Kassala hospital, eastern Sudan during 2005-2009. J Matern Fetal Neonatal Med. 2011;1077–8. http://dx.doi.org/10.3109/14767058.2010.545908 PMid:21231847

Ali AA, Okud A, Khojali A, Adam I. High incidence of obstetric complications in Kassala Hospital, Eastern Sudan. J Obstet Gynaecol (Lahore). 2012;32(2):148–9. http://dx.doi.org/10.3109/01443615.2011.637140 PMid:22296425

Bakheit KH, Bayoumi NK, Eltom AM, Elbashir MI, Adam I. Cytokines profiles in Sudanese women with preeclampsia. Hypertens Pregnancy. 2009;28(2):224–9. http://dx.doi.org/10.1080/10641950802601245 PMid:19437232

Bakheit KH, Ghebremeskel K, Pol K, Elbashir MI, Adam I. Erythrocyte omega-3 and omega-6 fatty acids profile in Sudanese women with pre-eclampsia. J Obstet Gynaecol . 2010;30(2):151–4. http://dx.doi.org/10.3109/01443610903391005 PMid:20143974

Bakheit KH, Ghebremeskel K, Zaiger G, Elbashir MI, Adam I. Erythrocyte antioxidant enzymes and plasma antioxidant vitamins in Sudanese women with pre-eclampsia. J Obstet Gynaecol. 2010;30(2):147–50. http://dx.doi.org/10.3109/01443610903249448 PMid:20143973

Adam I, Elhassan EM, Mohmmed A a, Salih MM, Elbashir MI. Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan. Malar J. 2011;10(1):258. http://dx.doi.org/10.1186/1475-2875-10-258 PMid:21899731 PMCid:PMC3224261

Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low- and middle-income countries: a WHO secondary analysis. PLoS One. 2014 Jan;9(3):e91198. http://dx.doi.org/10.1371/journal.pone.0091198 PMid:24657964 PMCid:PMC3962376

Amin NS, Tahir SA, Abadi NA, Kubba K. Association of blood groups with preeclamptic toxemia. Med Sci Res. 1989;17:861–2.

Scott JR, Beer AE, Stastny P. Immunogenetic factors in preeclampsia and eclampsia. Erythrocyte, histocompatibility, and Y-dependent antigens. JAMA. 1976;235(4):402–4. http://dx.doi.org/10.1001/jama.1976.03260300028025 PMid:54446

Published

2016-09-24

How to Cite

1.
Elmugabil A, Rayis DA, Ahmed MA, Adam I, Gasim GI. O Blood Group as Risk Factor for Preeclampsia among Sudanese Women. Open Access Maced J Med Sci [Internet]. 2016 Sep. 24 [cited 2021 Sep. 20];4(4):603-6. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2016.108

Issue

Section

B - Clinical Sciences

Most read articles by the same author(s)