Cigarette Smoking and Oxidative Stress in Patients with Coronary Artery Disease

Authors

  • Gordana Kamceva Clinical Hospital, Shtip
  • Zorica Arsova-Sarafinovska Institute of Public Health, Skopje
  • Tatjana Ruskovska Faculty of Medical Sciences, University "Goce Delchev", Shtip
  • Milka Zdravkovska Faculty of Medical Sciences, University "Goce Delchev", Shtip
  • Lidija Kamceva-Panova International Slavic University, G.R. Derzhavin, Sveti Nikole
  • Elisaveta Stikova Institute of Public Health, Skopje

DOI:

https://doi.org/10.3889/oamjms.2016.117

Keywords:

smoking, oxidative stress, coronary artery disease

Abstract

AIM: To determine whether cigarette smoking, as a risk factor for CAD, affects oxidative stress.

MATERIAL AND METHODS: The study included patients with CAD divided according to smoking status and number of cigarettes smoked during a whole day. In all subjects were examined biological markers of oxidative stress (concentration of oxidants and activity of antioxidant enzymes).

RESULTS: The study included 300 patients with CAD, with an average age of 62.97 ± 11.18 years, with a predominance of males. Of the total, 34.0% were active smokers, and 43.0% were non-smokers. The number of the most active smokers smoked cigarettes 1-20/day. In terms of concentration of oxidants (MDA and HP) it has not proved a significant difference between smokers versus non-smokers. Over the activity of antioxidant enzymes (SOD, CAT and GPX) statistically significant difference was found in the activity of GPX and among active smokers with CAD and non-smokers with CAD (p = 0.039).

CONCLUSION:Smoking as a risk factor for CAD is closely associated with increased oxidative stress and the number of cigarettes smoked plays an important role in increasing the level of oxidative damage and reduced antioxidant defence.

AIM: To determine whether cigarette smoking, as a risk factor for CAD, affects (anti)oxidant status.

MATERIAL AND METHODS: The study included patients with CAD, divided according to their smoking status and the number of cigarettes smoked during a day. Biological markers of oxidative stress (concentration of oxidants and activity of antioxidant enzymes) were measured in all subjects.

RESULTS: The study included 300 patients with CAD, (average age of 63 ± 11 years), predominantly males. Of the total, 34.0% were active smokers, 23.0% were former smokers, and 43.0% were non-smokers. Most of the active smokers smoked 1-20 cigarettes/day. In terms of concentration of oxidants (MDA and HP) there was not a significant difference between smokers versus non-smokers. As for the activity of antioxidant enzymes (SOD, CAT and GPX), a statistically significant difference was found in the activity of GPX among the active smokers with CAD and the non-smokers with CAD (p = 0.039).

CONCLUSION: Smoking as a risk factor for CAD is closely associated with increased oxidative stress, and the number of cigarettes smoked plays an important role in increasing the level of oxidative damage and reducing antioxidant defence.

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Published

2016-10-28

How to Cite

1.
Kamceva G, Arsova-Sarafinovska Z, Ruskovska T, Zdravkovska M, Kamceva-Panova L, Stikova E. Cigarette Smoking and Oxidative Stress in Patients with Coronary Artery Disease. Open Access Maced J Med Sci [Internet]. 2016 Oct. 28 [cited 2023 Feb. 4];4(4):636-40. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2016.117

Issue

Section

B - Clinical Sciences

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