Can Low Level Laser Therapy Benefit Bone Regeneration in Localized Maxillary Cystic Defects? - A Prospective Randomized Control Trial
DOI:
https://doi.org/10.3889/oamjms.2016.140Keywords:
LLLT, low intensity pulsed ultrasound, cystic lesion, digital radiographAbstract
AIM: The aim of the study was to evaluate the effect of Low-Level Laser Therapy (LLLT) on bone formation in cystic defects following cyst enucleation.
PATIENTS AND METHODS: The sample was composed of sixteen patients with enucleated maxillary bony cystic lesions. With an age range from 20 - 44 grouped as eight Laser and eight Control patients. Laser group was subjected to low intensity diode laser immediately after surgery and then for three times per week for two weeks using a therapeutic laser irradiation. Group B (control group): patients were not subjected laser therapy.
RESULTS: The predictor variable was exposure of bone defect to LLLT or none. The outcome variable was bone density changes measured by digital radiographs at day 1 and days 90 postoperatively. Descriptive and bivariate statistics were computed. There were no statistically significant differences between the 2 groups for the bone density at day 1. There was a statistically significant difference in bone density changes in each group at day 90: Significant at P ≤ 0.05. After adjusting for differences in day 1 for bone density, the estimated mean change in bone density changes at day 90 was significantly larger for Laser compared with control.
CONCLUSION: The results of this study suggested that LLLT can enhance bone healing in maxillary cystic defects. This can serve as an adjunct method in preventing possible delayed healing and pathological fractures This also will be helpful for more researchers in early loading in case of dental implants to accelerate osseointegration.
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Von Arx T, Buser D. Horizontal ridge augmentation using autogenous block grafts and the guided bone regeneration technique with collagen membranes: a clinical study with 42 patients. Clinical Oral Implants Research. 2006;17(4):359-66. https://doi.org/10.1111/j.1600-0501.2005.01234.x PMid:16907765 DOI: https://doi.org/10.1111/j.1600-0501.2005.01234.x
Yang X, Qin L, Liang W, Wang W, Tan J, Liang P, Xu J, Li S, Cui S. New bone formation and microstructure assessed by combination of confocal laser scanning microscopy and differential interference contrast microscopy. Calcified Tissue International. 2014;94(3):338-47. https://doi.org/10.1007/s00223-013-9815-6 PMid:24253488 DOI: https://doi.org/10.1007/s00223-013-9815-6
Schmidt-Bleek K, Schell H, Schulz N, Hoff P, Perka C, Buttgereit F, Volk HD, Lienau J, Duda GN. Inflammatory phase of bone healing initiates the regenerative healing cascade. Cell and Tissue Research. 2012;347(3):567-73. https://doi.org/10.1007/s00441-011-1205-7 PMid:21789579 DOI: https://doi.org/10.1007/s00441-011-1205-7
Hawkins D, Houreld N, Abrahamse H. Low level laser therapy (LLLT) as an effective therapeutic modality for delayed wound healing. Annals of the New York Academy of Sciences. 2005;1056(1):486-93. https://doi.org/10.1196/annals.1352.040 PMid:16387711 DOI: https://doi.org/10.1196/annals.1352.040
Blumenfeld I, Srouji S, Lanir Y, Laufer D, Livne E. Enhancement of bone defect healing in old rats by TGF-beta and IGF-1. Exp Gerontol. 2002;37(4):553-65. https://doi.org/10.1016/S0531-5565(01)00215-7 DOI: https://doi.org/10.1016/S0531-5565(01)00215-7
Renno AC, McDonnell PA, Parizotto NA, Laakso EL. The effects of laser irradiation on osteoblast and osteosarcoma cell proliferation and differentiation in vitro. Photomed Laser Surg. 2007;25(4):275-80. https://doi.org/10.1089/pho.2007.2055 PMid:17803384 DOI: https://doi.org/10.1089/pho.2007.2055
Kazem Shakouri S, Soleimanpour J, Salekzamani Y, Oskuie MR. Effect of low-level laser therapy on the fracture healing process. Lasers Med Sci. 2010;25(1):73-7. https://doi.org/10.1007/s10103-009-0670-7 PMid:19399356
Park JJ, Kang KL. Effect of 980-nm GaAlAs diode laser irradiation on healing of extraction sockets in streptozotocin-induced diabetic rats: a pilot study. Lasers Med Sci. 2012;27(1):223-30. https://doi.org/10.1007/s10103-011-0944-8 PMid:21732114 DOI: https://doi.org/10.1007/s10103-011-0944-8
Bodner L. Osseous regeneration in the jaws using demineralized allogenic bone implants. J Craniomaxillofac Surg. 1998;26(2):116-20. https://doi.org/10.1016/S1010-5182(98)80051-6 DOI: https://doi.org/10.1016/S1010-5182(98)80051-6
Bowers G, Feiton F, Middleton C, Glynn D, Sharp S, Mellonig J, Corio R, Emerson J, Park S, Suzuki J, Ma S. Histologic comparison of regeneration in human intrabony defects when osteogenin is combined with demineralized freeze-dried bone allograft and with purified bovine collagen. Journal of Periodontology. 1991;62(11):690-702. https://doi.org/10.1902/jop.1991.62.11.690 PMid:1753322 DOI: https://doi.org/10.1902/jop.1991.62.11.690
Hosny M, Sharawy M. Osteoinduction in young and old rats using demineralized bone powder allografts. J Oral Maxillofac Surg. 1985;43(12):925-31. https://doi.org/10.1016/0278-2391(85)90004-7 DOI: https://doi.org/10.1016/0278-2391(85)90004-7
Costello BJ, Betts NJ, Barber HD, Fonseca RJ. Preprosthetic surgery for the edentulous patients. Dent Clin North Am. 1996;40(1):19-38. PMid:8635621 DOI: https://doi.org/10.1016/S0011-8532(22)00160-4
Dahaba ME, and M. Effect of diode laser therapy on healing of persistent periradicular lesions in endodontically treated teeth. Egypt Dent J. 2001;47: 299–309.
Dörtbudak O, Haas R, Mallath-Pokorny G. Biostimulation of bone marrow cells with a diode soft laser. Clin Oral Implants Res. 2000;11(6):540-5. https://doi.org/10.1034/j.1600-0501.2000.011006540.x PMid:11168247 DOI: https://doi.org/10.1034/j.1600-0501.2000.011006540.x
Ninomiya T, Hosoya A, Nakamura H, Sano K, Nishisaka T, Ozawa H. Increase of bone volume by a nanosecond pulsed laser irradiation is caused by a decreased osteoclast number and an activated osteoblasts. Bone. 2007;40(1):140-8. https://doi.org/10.1016/j.bone.2006.07.026 PMid:16978938 DOI: https://doi.org/10.1016/j.bone.2006.07.026
Neiburger EJ. Rapid healing of gingival incisions by the helium-neon diode laser. J Mass Dent Soc. 1999;48(1):8-13, 40. PMid:10740521
Ueda Y, Shimizu N. Pulse irradiation of low-power laser stimulates bone nodule formation. J Oral Sci. 2001;43(1):55-60. https://doi.org/10.2334/josnusd.43.55 PMid:11383637 DOI: https://doi.org/10.2334/josnusd.43.55
Khadra M, Kasem N, Haanaes HR, JE, SL. Enhancement of bone formation in rat clavarial bone defects using low level laser therapy. Oral Surg Oral Med Oral Pathol. 2004;97:693–700. https://doi.org/10.1016/j.tripleo.2003.11.008 DOI: https://doi.org/10.1016/j.tripleo.2003.11.008
Chiapasco M, Rossi A, Motta JJ, Crescentini M. Spontaneous bone regeneration after enucleation of large mandibular cysts: a radiographic computed analysis of 27 consecutive cases. Journal of oral and maxillofacial surgery. 2000;58(9):942-8. https://doi.org/10.1053/joms.2000.8732 PMid:10981973 DOI: https://doi.org/10.1053/joms.2000.8732
Miller M, Truhe T. Lasers in dentistry: an overview. The Journal of the American Dental Association. 1993;124(2):32-5. https://doi.org/10.14219/jada.archive.1993.0034 PMid:8429182 DOI: https://doi.org/10.14219/jada.archive.1993.0034
Kim YD, Kim SS, Hwang DS, Kim SG, Kwon YH, Shin SH, Kim UK, Kim JR, Chung IK. Effect of lowâ€level laser treatment after installation of dental titanium implantâ€immunohistochemical study of RANKL, RANK, OPG: An experimental study in rats. Lasers in Surgery and Medicine. 2007;39(5):441-50. https://doi.org/10.1002/lsm.20508 PMid:17523169 DOI: https://doi.org/10.1002/lsm.20508
Kreisner PE, Blaya DS, Gaião L, Maciel-Santos ME, Etges A, Santana-Filho M, de Oliveira MG. Histological evaluation of the effect of low-level laser on distraction osteogenesis in rabbit mandibles. Med Oral Patol Oral Cir Bucal. 2010;15(4):e616-8. https://doi.org/10.4317/medoral.15.e616 PMid:20038884 DOI: https://doi.org/10.4317/medoral.15.e616
Pyo SJ, Song WW, Kim IR, Park BS, Kim CH, Shin SH, Chung IK, Kim YD. Low-level laser therapy induces the expressions of BMP-2, osteocalcin, and TGF-β1 in hypoxic-cultured human osteoblasts. Lasers Med Sci. 2013;28(2):543-50. https://doi.org/10.1007/s10103-012-1109-0 PMid:22552925 DOI: https://doi.org/10.1007/s10103-012-1109-0
Shakouri SK, Soleimanpour J, Salekzamani Y, Oskuie MR. Effect of low-level laser therapy on the fracture healing process. Lasers in medical science. 2010;25(1):73-7. https://doi.org/10.1007/s10103-009-0670-7 PMid:19399356 DOI: https://doi.org/10.1007/s10103-009-0670-7
Roodenburg JL, Witjes MJ, de Veld DC, Tan IB, Nauta JM. [Lasers in dentistry 8. Use of lasers in oral and maxillofacial surgery]. Ned Tijdschr Tandheelkd. 2002;109(12):470-4. PMid:12572097
El Desouky G, Mekky M, Salah El Din M, K. Z. and W. A. Radiodensitometric assesment of the effect of diode laser on bone density following loading of lased endosseous implants. Egypt Dent Assoc. 2007;53:1223.
Fukuoka H, Daigo Y, Enoki N, Taniguchi K, Sato H. Influence of carbon dioxide laser irradiation on the healing process of extraction sockets. Acta Odontol Scand. 2011;69(1):33-40. https://doi.org/10.3109/00016357.2010.517556 PMid:20863148 DOI: https://doi.org/10.3109/00016357.2010.517556
Jakse N, Payer M, Tangl S, Berghold A, Kirmeier R, Lorenzoni M. Influence of lowâ€level laser treatment on bone regeneration and osseointegration of dental implants following sinus augmentation: An experimental study on sheep. Clinical oral implants research. 2007;18(4):517-24. https://doi.org/10.1111/j.1600-0501.2007.01369.x PMid:17451409 DOI: https://doi.org/10.1111/j.1600-0501.2007.01369.x
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